P26040: Ezrin

General Information

Protein names	- Ezrin - Cytovillin - Villin-2 - p81
Gene names	Ezr
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P26040

12 N-termini

11 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLQYV DNKGFPTWLK
        70         80         90        100        110        120
LDKKVSAQEV RKENPVQFKF RAKFYPEDVA EELIQDITQK LFFLQVKDGI LSDEIYCPPE
       130        140        150        160        170        180
TAVLLGSYAV QAKFGDYNKE MHKSGYLSSE RLIPQRVMDQ HKLSRDQWED RIQVWHAEHR
       190        200        210        220        230        240
GMLKDSAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF
       250        260        270        280        290        300
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI
       310        320        330        340        350        360
EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM LREKEELMLR LQDYEQKTKR
       370        380        390        400        410        420
AEKELSEQIE KALQLEEERR RAQEEAERLE ADRMAALRAK EELERQAQDQ IKSQEQLAAE
       430        440        450        460        470        480
LAEYTAKIAL LEEARRRKED EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP
       490        500        510        520        530        540
VNYHVQEGLQ DEGAEPMGYS AELSSEGILD DRNEEKRITE AEKNERVQRQ LLTLSNELSQ
       550        560        570        580
ARDENKRTHN DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAM

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 11 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P26040-2-unknown	PKPINV...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P26040-2-unknown	PKPINV...	2	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P26040-190-unknown	EYLKIA...	190	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P26040-262-unknown	KKAPDF...	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33470
P26040-263-unknown	KAPDFV...	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33471
P26040-264-unknown	APDFVF...	264	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33472
P26040-302-unknown	VQQMKA...	302	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29873
P26040-424-unknown	YTAKIA...	424	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33473
P26040-503-unknown	LSSEGI...	503	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33474
P26040-531-unknown	LLTLSN...	531	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33475
P26040-532-unknown	LTLSNE...	532	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29874
P26040-533-unknown	TLSNEL...	533	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29875
P26040-534-unknown	LSNELS...	534	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33476

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IKPIDK	261	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33470
...KPIDKK	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33471
...PIDKKA	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33472
...PDTIEV	301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29873
...AELAEY	423	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33473
...GYSAEL	502	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33474
...RVQRQL	530	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33475
...VQRQLL	531	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29874
...QRQLLT	532	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29875
...RQLLTL	533	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33476
...EFEAM	586	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	261	PIDK.\|.KKAP	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	262	IDKK.\|.KAPD	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	263	DKKA.\|.APDF	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	301	TIEV.\|.VQQM	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EZRI_MOUSE @301
MMP2_MOUSE	423	LAEY.\|.YTAK	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	502	SAEL.\|.LSSE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	530	QRQL.\|.LLTL	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	531	RQLL.\|.LTLS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EZRI_MOUSE @531
CATE_MOUSE	532	QLLT.\|.TLSN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> EZRI_MOUSE @532
MMP2_MOUSE	533	LLTL.\|.LSNE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)