Q03350: Thrombospondin-2

General Information

Protein names	- Thrombospondin-2
Gene names	Thbs2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q03350

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLWALALLAL GIGPRASAGD HVKDTSFDLF SISNINRKTI GAKQFRGPDP GVPAYRFVRF
        70         80         90        100        110        120
DYIPPVNTDD LNRIVKLARR KEGFFLTAQL KQDRKSRGTL LVLEGPGTSQ RQFEIVSNGP
       130        140        150        160        170        180
GDTLDLNYWV EGNQHTNFLE DVGLADSQWK NVTVQVASDT YSLYVGCDLI DSVTLEEPFY
       190        200        210        220        230        240
EQLEVDRSRM YVAKGASRES HFRGLLQNVH LVFADSVEDI LSKKGCQHSQ GAEVNTISEH
       250        260        270        280        290        300
TETLHLSPHI TTDLVVQGVE KAQEVCTHSC EELSNMMNEL SGLHVMVNQL SKNLERVSSD
       310        320        330        340        350        360
NQFLLELIGG PLKTRNMSAC VQEGRIFAEN ETWVVDSCTT CTCKKFKTVC HQITCSPATC
       370        380        390        400        410        420
ANPSFVEGEC CPSCSHSADS DEGWSPWAEW TECSVTCGSG TQQRGRSCDV TSNTCLGPSI
       430        440        450        460        470        480
QTRTCSLGKC DTRIRQNGGW SHWSPWSSCS VTCGVGNVTR IRLCNSPVPQ MGGKNCKGSG
       490        500        510        520        530        540
RETKPCQRDP CPIDGRWSPW SPWSACTVTC AGGIRERSRV CNSPEPQYGG KDCVGDVTEH
       550        560        570        580        590        600
QMCNKRSCPI DGCLSNPCFP GAKCNSFPDG SWSCGSCPVG FLGNGTHCED LDECAVVTDI
       610        620        630        640        650        660
CFSTNKAPRC VNTNPGFHCL PCPPRYKGNQ PFGVGLEDAR TEKQVCEPEN PCKDKTHSCH
       670        680        690        700        710        720
KNAECIYLGH FSDPMYKCEC QIGYAGDGLI CGEDSDLDGW PNNNLVCATN ATYHCIKDNC
       730        740        750        760        770        780
PKLPNSGQED FDKDGIGDAC DEDDDNDGVS DEKDNCQLLF NPRQLDYDKD EVGDRCDNCP
       790        800        810        820        830        840
YVHNPAQIDT DNNGEGDACS VDIDGDDVFN ERDNCPYVYN TDQRDTDGDG VGDHCDNCPL
       850        860        870        880        890        900
MHNPDQIDQD NDLVGDQCDN NEDIDDDGHQ NNQDNCPYIS NSNQADHDND GKGDACDSDD
       910        920        930        940        950        960
DNDGVPDDRD NCRLVFNPDQ EDSDGDGRGD ICKDDFDNDN VPDIDDVCPE NNAITETDFR
       970        980        990       1000       1010       1020
NFQMVPLDPK GTTQIDPNWV IRHQGKELVQ TANSDPGIAV GFDEFGSVDF SGTFYVNTDR
      1030       1040       1050       1060       1070       1080
DDDYAGFVFG YQSSSRFYVV MWKQVTQTYW EDKPSRAYGY SGVSLKVVNS TTGTGEHLRN
      1090       1100       1110       1120       1130       1140
ALWHTGNTEG QVRTLWHDPK NIGWKDYTAY RWHLIHRPKT GYMRVLVHEG KQVMADSGPI
      1150       1160       1170
YDQTYAGGRL GLFVFSQEMV YFSDLKYECR DA

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q03350-19-unmodified	GDHVKD...	19		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q03350-19-unknown	GDHVKD...	19	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q03350-19-unknown	GDHVKD...	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33888
Q03350-20-unknown	DHVKDT...	20	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33889
Q03350-307-unknown	LIGGPL...	307	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33890

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRASAG	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33888
...RASAGD	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33889
...QFLLEL	306	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33890
...ECRDA	1172	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	18	ASAG.\|.GDHV	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	19	SAGD.\|.DHVK	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	306	LLEL.\|.LIGG	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)