Q9DBG3: AP-2 complex subunit beta

General Information

Protein names	- AP-2 complex subunit beta - AP105B - Adaptor protein complex AP-2 subunit beta - Adaptor-related protein complex 2 subunit beta - Beta-2-adaptin - Beta-adaptin - Clathrin assembly protein complex 2 beta large chain - Plasma membrane adaptor HA2/AP2 adaptin beta subunit
Gene names	Ap2b1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9DBG3

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT
        70         80         90        100        110        120
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE
       130        140        150        160        170        180
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA
       190        200        210        220        230        240
VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI
       250        260        270        280        290        300
CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY
       310        320        330        340        350        360
VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
       370        380        390        400        410        420
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK
       430        440        450        460        470        480
YPNKYESIIA TLCENLDSLD EPDARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV
       490        500        510        520        530        540
QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV
       550        560        570        580        590        600
VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST
       610        620        630        640        650        660
DAGDSPVGTT TTTNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM GAVDLLGGGL
       670        680        690        700        710        720
DSLVGQSFIP SSVPATFAPS PTPAVVSSGL NDLFELSTGI GMAPGGYVAP KAVWLPAVKA
       730        740        750        760        770        780
KGLEISGTFT HRQGHIYMEM NFTNKALQHM TDFAIQFNKN SFGVIPSTPL AIHTPLMPNQ
       790        800        810        820        830        840
SIDVSLPLNT LGPVMKMEPL NNLQVAVKNN IDVFYFSCLI PLNVLFVEDG KMERQVFLAT
       850        860        870        880        890        900
WKDIPNENEL QFQIKECHLN ADTVSSKLQN NNVYTIAKRN VEGQDMLYQS LKLTNGIWIL
       910        920        930
AELRIQPGNP NYTLSLKCRA PEVSQYIYQV YDSILKN

Isoforms

- Isoform 2 of AP-2 complex subunit beta

Sequence View

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9DBG3-1-unknown	MTDSKY...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67148
Q9DBG3-2-unknown	MTDSKY...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9DBG3-2-unknown	MTDSKY...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9DBG3-2-Acetylation	TDSKYF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9DBG3-2-Acetylation	TDSKYF...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110742
Q9DBG3-2-Acetylation	TDSKYF...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9DBG3-18-unknown	LKAELN...	18		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31097
Q9DBG3-18-unknown	LKAELN...	18		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136722
Q9DBG3-19-unknown	KAELNN...	19		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31099
Q9DBG3-19-unknown	KAELNN...	19		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136785
Q9DBG3-581-unknown	FVEGSH...	581		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34270
Q9DBG3-581-unknown	FVEGSH...	581		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154347

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GEIFEL	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31097
...EIFELK	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31099
...KPPNAF	580	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34270
...KPPNAF	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137768
...SILKN	937	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SILKN	937	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62766

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	17	IFEL.\|.LKAE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> AP2B1_MOUSE @17
CATE_MOUSE	18	FELK.\|.KAEL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> AP2B1_MOUSE @18
MMP2_MOUSE	580	PNAF.\|.FVEG	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)