Q01853: Transitional endoplasmic reticulum ATPase

General Information

Protein names	- Transitional endoplasmic reticulum ATPase - TER ATPase - 3.6.4.6 {ECO:0000250\|UniProtKB:P55072} - 15S Mg(2+)-ATPase p97 subunit - Valosin-containing protein - VCP
Gene names	Vcp
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01853

22 N-termini

18 C-termini

17 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASGADSKGD DLSTAILKQK NRPNRLIVDE AINEDNSVVS LSQPKMDELQ LFRGDTVLLK
        70         80         90        100        110        120
GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI SIQPCPDVKY GKRIHVLPID
       130        140        150        160        170        180
DTVEGITGNL FEVYLKPYFL EAYRPIRKGD IFLVRGGMRA VEFKVVETDP SPYCIVAPDT
       190        200        210        220        230        240
VIHCEGEPIK REDEEESLNE VGYDDIGGCR KQLAQIKEMV ELPLRHPALF KAIGVKPPRG
       250        260        270        280        290        300
ILLYGPPGTG KTLIARAVAN ETGAFFFLIN GPEIMSKLAG ESESNLRKAF EEAEKNAPAI
       310        320        330        340        350        360
IFIDELDAIA PKREKTHGEV ERRIVSQLLT LMDGLKQRAH VIVMAATNRP NSIDPALRRF
       370        380        390        400        410        420
GRFDREVDIG IPDATGRLEI LQIHTKNMKL ADDVDLEQVA NETHGHVGAD LAALCSEAAL
       430        440        450        460        470        480
QAIRKKMDLI DLEDETIDAE VMNSLAVTMD DFRWALSQSN PSALRETVVE VPQVTWEDIG
       490        500        510        520        530        540
GLEDVKRELQ ELVQYPVEHP DKFLKFGMTP SKGVLFYGPP GCGKTLLAKA IANECQANFI
       550        560        570        580        590        600
SIKGPELLTM WFGESEANVR EIFDKARQAA PCVLFFDELD SIAKARGGNI GDGGGAADRV
       610        620        630        640        650        660
INQILTEMDG MSTKKNVFII GATNRPDIID PAILRPGRLD QLIYIPLPDE KSRVAILKAN
       670        680        690        700        710        720
LRKSPVAKDV DLEFLAKMTN GFSGADLTEI CQRACKLAIR ESIESEIRRE RERQTNPSAM
       730        740        750        760        770        780
EVEEDDPVPE IRRDHFEEAM RFARRSVSDN DIRKYEMFAQ TLQQSRGFGS FRFPSGNQGG
       790        800
AGPSQGSGGG TGGSVYTEDN DDDLYG

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

22 N-termini - 18 C-termini - 17 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01853-2-unknown	MASGAD...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q01853-2-unknown	MASGAD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01853-2-Acetylation	ASGADS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01853-2-Acetylation	ASGADS...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q01853-26-unknown	LIVDEA...	26		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33866
Q01853-31-unknown	AINEDN...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30388
Q01853-41-unknown	LSQPKM...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33867
Q01853-70-unknown	IVLSDD...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30389
Q01853-99-unknown	VISIQP...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33868
Q01853-175-unknown	IVAPDT...	175		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33869
Q01853-199-unknown	NEVGYD...	199		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30390
Q01853-240-unknown	GILLYG...	240		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q01853-241-unknown	ILLYGP...	241		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34631
Q01853-244-unmodified	YGPPGT...	244			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q01853-278-unknown	LAGESE...	278		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33870
Q01853-329-unknown	LTLMDG...	329		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30391
Q01853-464-unknown	LRETVV...	464		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33871
Q01853-573-unmodified	VLFFDE...	573			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q01853-573-unknown	VLFFDE...	573		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33872
Q01853-639-unknown	LDQLIY...	639		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33873
Q01853-675-unknown	LAKMTN...	675		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30392
Q01853-720-unknown	MEVEED...	720		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33874
Q01853-758-unknown	FAQTLQ...	758		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30393
Q01853-759-unknown	AQTLQQ...	759		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30394

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NRPNRL	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33866
...LIVDEA	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30388
...NSVVSL	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33867
...REAVCI	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30389
...VRLGDV	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33868
...PSPYCI	174	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33869
...EEESLN	198	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30390
...KPPRGI	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34631
...EIMSKL	277	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33870
...IVSQLL	328	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30391
...SNPSAL	463	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33871
...QAAPCV	572	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33872
...LRPGRL	638	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33873
...VDLEFL	674	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30392
...TNPSAM	719	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33874
...RKYEMF	757	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30393
...KYEMFA	758	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30394
...DDLYG	806	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	25	PNRL.\|.LIVD	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> TERA_MOUSE @25
CATE_MOUSE	30	VDEA.\|.AINE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TERA_MOUSE @30
MMP2_MOUSE	40	VVSL.\|.LSQP	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	69	AVCI.\|.IVLS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TERA_MOUSE @69
MMP2_MOUSE	98	LGDV.\|.VISI	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	174	PYCI.\|.IVAP	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	198	ESLN.\|.NEVG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TERA_MOUSE @198
MMP9_MOUSE	240	PRGI.\|.ILLY	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	277	MSKL.\|.LAGE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	328	SQLL.\|.LTLM	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TERA_MOUSE @328
MMP2_MOUSE	463	PSAL.\|.LRET	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> TERA_MOUSE @463
MMP2_MOUSE	572	APCV.\|.VLFF	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	638	PGRL.\|.LDQL	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	674	LEFL.\|.LAKM	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TERA_MOUSE @674
MMP2_MOUSE	719	PSAM.\|.MEVE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	757	YEMF.\|.FAQT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TERA_MOUSE @757
CATE_MOUSE	758	EMFA.\|.AQTL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TERA_MOUSE @758

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)