P46460: Vesicle-fusing ATPase

General Information

Protein names	- Vesicle-fusing ATPase - 3.6.4.6 - N-ethylmaleimide-sensitive fusion protein - NEM-sensitive fusion protein - Suppressor of K(+) transport growth defect 2 - Protein SKD2 - Vesicular-fusion protein NSF
Gene names	Nsf
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P46460

4 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGRTMQAAR CPTDELSLSN CAVVNEKDFQ SGQHVMVRTS PNHKYIFTLR THPSVVPGCI
        70         80         90        100        110        120
AFSLPQRKWA GLSIGQDIEV ALYSFDKAKQ CIGTMTIEID FLQKKNIDSN PYDTDKMAAE
       130        140        150        160        170        180
FIQQFNNQAF SVGQQLVFSF NDKLFGLLVK DIEAMDPSIL KGEPASGKRQ KIEVGLVVGN
       190        200        210        220        230        240
SQVAFEKAEN SSLNLIGKAK TKENRQSIIN PDWNFEKMGI GGLDKEFSDI FRRAFASRVF
       250        260        270        280        290        300
PPEIVEQMGC KHVKGILLYG PPGCGKTLLA RQIGKMLNAR EPKVVNGPEI LNKYVGESEA
       310        320        330        340        350        360
NIRKLFADAE EEQRRLGANS GLHIIIFDEI DAICKQRGSM AGSTGVHDTV VNQLLSKIDG
       370        380        390        400        410        420
VEQLNNILVI GMTNRPDLID EALLRPGRLE VKMEIGLPDE KGRLQILHIH TARMRGHQLL
       430        440        450        460        470        480
SADVDIKELA VETKNFSGAE LEGLVRAAQS TAMNRHIKAS TKVEVDMEKA ESLQVTRGDF
       490        500        510        520        530        540
LASLENDIKP AFGTNQEDYA SYIMNGIIKW GDPVTRVLDD GELLVQQTKN SDRTPLVSVL
       550        560        570        580        590        600
LEGPPHSGKT ALAAKIAEES NFPFIKICSP DKMIGFSETA KCQAMKKIFD DAYKSQLSCV
       610        620        630        640        650        660
VVDDIERLLD YVPIGPRFSN LVLQALLVLL KKAPPQGRKL LIIGTTSRKD VLQEMEMLNA
       670        680        690        700        710        720
FSTTIHVPNI ATGEQLLEAL ELLGNFKDKE RTTIAQQVKG KKVWIGIKKL LMLIEMSLQM
       730        740
DPEYRVRKFL ALMREEGASP LDFD

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P46460-1-unknown	MAGRTM...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P46460-36-unknown	MVRTSP...	36	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000133591
P46460-196-unknown	IGKAKT...	196	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29962
P46460-305-unknown	LFADAE...	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33563

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GQDIEV	79	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000133603
...SSLNLI	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29962
...PPEIVE	245	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000133591
...ANIRKL	304	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33563
...PLDFD	744	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	195	LNLI.\|.IGKA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> NSF_MOUSE @195
MMP2_MOUSE	304	IRKL.\|.LFAD	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)