P50247: Adenosylhomocysteinase

General Information

Protein names	- Adenosylhomocysteinase - AdoHcyase - 3.3.1.1 - CUBP - Liver copper-binding protein - S-adenosyl-L-homocysteine hydrolase
Gene names	Ahcy
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P50247

9 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDKLPYKVA DIGLAAWGRK ALDIAENEMP GLMRMREMYS ASKPLKGARI AGCLHMTVET
        70         80         90        100        110        120
AVLIETLVAL GAEVRWSSCN IFSTQDHAAA AIAKAGIPVF AWKGETDEEY LWCIEQTLHF
       130        140        150        160        170        180
KDGPLNMILD DGGDLTNLIH TKYPQLLSGI RGISEETTTG VHNLYKMMSN GILKVPAINV
       190        200        210        220        230        240
NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVAVVAG YGDVGKGCAQ ALRGFGARVI
       250        260        270        280        290        300
ITEIDPINAL QAAMEGYEVT TMDEACKEGN IFVTTTGCVD IILGRHFEQM KDDAIVCNIG
       310        320        330        340        350        360
HFDVEIDVKW LNENAVEKVN IKPQVDRYWL KNGRRIILLA EGRLVNLGCA MGHPSFVMSN
       370        380        390        400        410        420
SFTNQVMAQI ELWTHPDKYP VGVHFLPKKL DEAVAEAHLG KLNVKLTKLT EKQAQYLGMP
       430
INGPFKPDHY RY

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P50247-2-unknown	MSDKLP...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P50247-2-unknown	MSDKLP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50247-2-Acetylation	SDKLPY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50247-2-Acetylation	SDKLPY...	2	acetylation-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P50247-2-Acetylation	SDKLPY...	2	acetylation-		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P50247-2-Acetylation	SDKLPY...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P50247-9-unknown	VADIGL...	9			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P50247-20-unknown	KALDIA...	20			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P50247-21-unknown	ALDIAE...	21			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P50247-38-unknown	MYSASK...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33592
P50247-47-unknown	GARIAG...	47		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P50247-130-unknown	DDGGDL...	130		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P50247-187-unknown	SKFDNL...	187			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P50247-187-unknown	SKFDNL...	187		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50247-187-unknown	SKFDNL...	187		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MRMREM	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33592
...KGETDE	107	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000116774
...DHYRY	432	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	37	MREM.\|.MYSA	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)