P63085: Mitogen-activated protein kinase 1

General Information

Protein names	- Mitogen-activated protein kinase 1 - MAP kinase 1 - MAPK 1 - 2.7.11.24 - ERT1 - Extracellular signal-regulated kinase 2 - ERK-2 - MAP kinase isoform p42 - p42-MAPK - Mitogen-activated protein kinase 2 - MAP kinase 2 - MAPK 2
Gene names	Mapk1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P63085

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAAAAGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNLNKVRVA IKKISPFEHQ
        70         80         90        100        110        120
TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL YKLLKTQHLS
       130        140        150        160        170        180
NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG
       190        200        210        220        230        240
FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG
       250        260        270        280        290        300
ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK MLTFNPHKRI
       310        320        330        340        350
EVEQALAHPY LEQYYDPSDE PIAEAPFKFD MELDDLPKEK LKELIFEETA RFQPGYRS

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P63085-2-unknown	MAAAAA...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P63085-2-unknown	MAAAAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P63085-2-Acetylation	AAAAAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P63085-2-Acetylation	AAAAAA...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P63085-243-unknown	GSPSQE...	243		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000115125
P63085-341-unknown	LKELIF...	341		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33738

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LPKEKL	340	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33738
	...PGYRS	358	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	340	KEKL.\|.LKEL	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)