Q8R050: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

General Information

Protein names	- Eukaryotic peptide chain release factor GTP-binding subunit ERF3A - Eukaryotic peptide chain release factor subunit 3a - eRF3a - G1 to S phase transition protein 1 homolog
Gene names	Gspt1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8R050

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDPSSGGGGG GGGGGSSSSS DSAPDCWDQT DMEAPGPGPC GGGGSGSGSM AAVAEAQREN
        70         80         90        100        110        120
LSAAFSRQLN VNAKPFVPNV HAAEFVPSFL RGPAQPPLSP AGAAGGDHGA GSGAGGPSEP
       130        140        150        160        170        180
VESSQDQSCE GSNSTVSMEL SEPVVENGET EMSPEESWEH KEEISEAEPG GGSSGDGRPP
       190        200        210        220        230        240
EESTQEMMEE EEEIPKPKSA VAPPGAPKKE HVNVVFIGHV DAGKSTIGGQ IMYLTGMVDK
       250        260        270        280        290        300
RTLEKYEREA KEKNRETWYL SWALDTNQEE RDKGKTVEVG RAYFETEKKH FTILDAPGHK
       310        320        330        340        350        360
SFVPNMIGGA SQADLAVLVI SARKGEFETG FEKGGQTREH AMLAKTAGVK HLIVLINKMD
       370        380        390        400        410        420
DPTVNWSNER YEECKEKLVP FLKKVGFNPK KDIHFMPCSG LTGANLKEQS DFCPWYIGLP
       430        440        450        460        470        480
FIPYLDNLPN FNRSVDGPIR LPIVDKYKDM GTVVLGKLES GSICKGQQLV MMPNKHNVEV
       490        500        510        520        530        540
LGILSDDVET DSVAPGENLK IRLKGIEEEE ILPGFILCDL NNLCHSGRTF DAQIVIIEHK
       550        560        570        580        590        600
SIICPGYNAV LHIHTCIEEV EITALICLVD KKSGEKSKTR PRFVKQDQVC IARLRTAGTI
       610        620        630
CLETFKDFPQ MGRFTLRDEG KTIAIGKVLK LVPEKD

Isoforms

- Isoform 2 of Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8R050-1-unknown	MDPSSG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8R050-1-unknown	MDPSSG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74122
Q8R050-263-unknown	ALDTNQ...	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34108
Q8R050-263-unknown	ALDTNQ...	263	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148886
Q8R050-483-unknown	ILSDDV...	483	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34110
Q8R050-483-unknown	ILSDDV...	483	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153222
Q8R050-602-unknown	LETFKD...	602	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30836
Q8R050-602-unknown	LETFKD...	602	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154598

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WYLSWA	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34108
...WYLSWA	262	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132264
...VEVLGI	482	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34110
...VEVLGI	482	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136648
...AGTICL	601	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30836
...AGTICL	601	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138022
...VPEKD	636	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VPEKD	636	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69740

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	262	LSWA.\|.ALDT	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	482	VLGI.\|.ILSD	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATE_MOUSE	601	TICL.\|.LETF	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ERF3A_MOUSE @601

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)