P40142: Transketolase

General Information

Protein names	- Transketolase - TK - 2.2.1.1 - P68
Gene names	Tkt
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P40142

16 N-termini

12 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEGYHKPDQQ KLQALKDTAN RLRISSIQAT TAAGSGHPTS CCSAAEIMAV LFFHTMRYKA
        70         80         90        100        110        120
LDPRNPHNDR FVLSKGHAAP ILYAVWAEAG FLPEAELLNL RKISSDLDGH PVPKQAFTDV
       130        140        150        160        170        180
ATGSLGQGLG AACGMAYTGK YFDKASYRVY CMLGDGEVSE GSVWEAMAFA GIYKLDNLVA
       190        200        210        220        230        240
IFDINRLGQS DPAPLQHQVD IYQKRCEAFG WHTIIVDGHS VEELCKAFGQ AKHQPTAIIA
       250        260        270        280        290        300
KTFKGRGITG IEDKEAWHGK PLPKNMAEQI IQEIYSQVQS KKKILATPPQ EDAPSVDIAN
       310        320        330        340        350        360
IRMPTPPSYK VGDKIATRKA YGLALAKLGH ASDRIIALDG DTKNSTFSEL FKKEHPDRFI
       370        380        390        400        410        420
ECYIAEQNMV SIAVGCATRD RTVPFCSTFA AFFTRAFDQI RMAAISESNI NLCGSHCGVS
       430        440        450        460        470        480
IGEDGPSQMA LEDLAMFRSV PMSTVFYPSD GVATEKAVEL AANTKGICFI RTSRPENAII
       490        500        510        520        530        540
YSNNEDFQVG QAKVVLKSKD DQVTVIGAGV TLHEALAAAE SLKKDKISIR VLDPFTIKPL
       550        560        570        580        590        600
DRKLILDSAR ATKGRILTVE DHYYEGGIGE AVSAAVVGEP GVTVTRLAVS QVPRSGKPAE
       610        620
LLKMFGIDKD AIVQAVKGLV TKG

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 12 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P40142-1-Acetylation	MEGYHK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P40142-1-Acetylation	MEGYHK...	1	acetylation-		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P40142-1-Acetylation	MEGYHK...	1	acetylation-		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P40142-4-unknown	YHKPDQ...	4		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P40142-56-unknown	MRYKAL...	56		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P40142-165-unknown	EAMAFA...	165		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P40142-282-unknown	KKILAT...	282		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33547
P40142-282-unknown	KKILAT...	282			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P40142-286-unknown	ATPPQE...	286		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29937
P40142-309-unknown	YKVGDK...	309		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33548
P40142-325-unknown	LAKLGH...	325		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33549
P40142-326-unknown	AKLGHA...	326		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29938
P40142-444-unknown	TVFYPS...	444		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33550
P40142-457-unknown	AVELAA...	457			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P40142-460-unknown	LAANTK...	460		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33551
P40142-461-unknown	AANTKG...	461		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29939
P40142-576-unknown	VVGEPG...	576		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33552
P40142-587-unknown	LAVSQV...	587		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33553
P40142-588-unknown	AVSQVP...	588		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29940

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVQSKK	281	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33547
...KKKILA	285	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29937
...PTPPSY	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33548
...AYGLAL	324	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33549
...YGLALA	325	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29938
...SVPMST	443	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33550
...EKAVEL	459	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33551
...KAVELA	460	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29939
...AVSAAV	575	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33552
...VTVTRL	586	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33553
...TVTRLA	587	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29940
...LVTKG	623	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	281	QSKK.\|.KKIL	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> TKT_MOUSE @281
CATE_MOUSE	285	KILA.\|.ATPP	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TKT_MOUSE @285
MMP2_MOUSE	308	PPSY.\|.YKVG	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	324	GLAL.\|.LAKL	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	325	LALA.\|.AKLG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TKT_MOUSE @325
MMP2_MOUSE	443	PMST.\|.TVFY	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	459	AVEL.\|.LAAN	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	460	VELA.\|.AANT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TKT_MOUSE @460
MMP2_MOUSE	575	SAAV.\|.VVGE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	586	VTRL.\|.LAVS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	587	TRLA.\|.AVSQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TKT_MOUSE @587

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)