Q9JKF1: Ras GTPase-activating-like protein IQGAP1

General Information

Protein names	- Ras GTPase-activating-like protein IQGAP1
Gene names	Iqgap1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9JKF1

16 N-termini

12 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSAAEEVDGL GVVRPHYGSV LDNERLTAEE MDERRRQNVA YEYLCHLEEA KRWMEACLGE
        70         80         90        100        110        120
DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ TRYKATGLHF RHTDNVIQWL
       130        140        150        160        170        180
NAMDEIGLPK IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD LYGKVDFTEE
       190        200        210        220        230        240
EINNMKIELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINEAIDR RVAADTFTAL
       250        260        270        280        290        300
KNPNAMLVNL EEGLAPTYQD VLYQAKQDKM TNAKNRTENS DRERDVYEEL LTQAEIQGNV
       310        320        330        340        350        360
NKVNTSSALA NISLALEQGC AVTLLKALQS LALGLRGLQT QNSDWYMKQL QSDLQQKRQS
       370        380        390        400        410        420
GQTDPLQKEE VQAGVDAANS AAQQYQRRLA AVAAINAAIQ KGIAEKTVLE LMNPEAQLPQ
       430        440        450        460        470        480
VYPFAADLYQ KELATLQQQS PEHSLTHPEL TVAVEMLSSV ALINRALESG DMTTVWKQLS
       490        500        510        520        530        540
SSVTGLTNIE EENCQRYLDE LMKLKAQAHA ENNAFITWND IQACVDHVNL VVHEEHERIL
       550        560        570        580        590        600
AIGLINEALD EGDAQKTLQA LQIPAAKLEG VLAEVAQHYQ DTLIRAKREK AQETQDESAV
       610        620        630        640        650        660
LWLDEIQGGI WQSNKDTQEA QRFALGISAI NEAVDSGDVG RTLSALRSPD VGLYGVIPEC
       670        680        690        700        710        720
GETYQSDLAE AKKKRLAAGD NNSKWVKHWV KGGYHYYHNL ETQAGGWAEP PDFVQNSVQL
       730        740        750        760        770        780
SREEIQSSIS GVTAAYNREQ LWLANEGLIT KLQACCRGYL VRQEFRSRMN FLKKQIPAIT
       790        800        810        820        830        840
CIQSQWRGYK QKKAYQDRLA YLHSHKDEVV KIQSLARMHQ ARKRYRDRLQ YFRDHINDII
       850        860        870        880        890        900
KIQAFIRANK ARDDYKTLIN AEDPPMIVVR KFVHLLDQSD QDFQEELDLM KMREEVITLI
       910        920        930        940        950        960
RSNQQLENDL NLMDIKIGLL VKNKITLQDV VSHSKKLTKK NKEQLSDMMM INKQKGGLKA
       970        980        990       1000       1010       1020
LSKEKREKLE AYQHLFYLLQ TNPTYLAKLI FQMPQNKSTK FMDSVIFTLY NYASNQREEY
      1030       1040       1050       1060       1070       1080
LLLRLFQTAL QEEIKSKVDQ IQEIVTGNPT VIKMVVSFNR GARGQNALRQ ILAPVVKEIM
      1090       1100       1110       1120       1130       1140
DDKSLNIKTD PVDIYKSWVN QMESQTGEAS KLPYDVTPEQ ALSHEEVKTR LDNSIRNMRA
      1150       1160       1170       1180       1190       1200
VTDKFLSAIV SSVDKIPYGM RFIAKVLKDS LHEKFPDAGE DELLKIIGNL LYYRYMNPAI
      1210       1220       1230       1240       1250       1260
VAPDAFDIID LSAGGQLTTD QRRNLGSIAK MLQHAASNKM FLGDNAHLSI INEYLSQSYQ
      1270       1280       1290       1300       1310       1320
KFRRFFQVAC DVPELQDKFN VDEYSDLVTL TKPVIYISIG EIINTHTLLL DHQDAIAPEH
      1330       1340       1350       1360       1370       1380
NDPIHELLDD LGEVPTIESL IGESCGNSND PNKEALAKTE VSLTLTNKFD VPGDENAEMD
      1390       1400       1410       1420       1430       1440
ARTILLNTKR LIVDVIRFQP GETLTEILET PATNEQEAEH QRAMQRRAIR DAKTPDKMKK
      1450       1460       1470       1480       1490       1500
SKPMKEDNNL SLQEKKEKIQ TGLKKLTELG TVDPKNRYQE LINDIAKDIR NQRRYRQRRK
      1510       1520       1530       1540       1550       1560
AELVKLQQTY SALNSKATFY GEQVDYYKSY IKTCLDNLAS KGKVSKKPRE MKGKKSKKIS
      1570       1580       1590       1600       1610       1620
LKYTAARLHE KGVLLEIEDL QANQFKNVIF EIGPTEEVGD FEVKAKFMGV QMETFMLHYQ
      1630       1640       1650
DLLQLQYEGV AVMKLFDRAK VNVNLLIFLL NKKFYGK

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

16 N-termini - 12 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9JKF1-2-unknown	MSAAEE...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q9JKF1-2-unknown	MSAAEE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9JKF1-2-Acetylation	SAAEEV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9JKF1-2-Acetylation	SAAEEV...	2	acetylation-		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
Q9JKF1-2-Acetylation	SAAEEV...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q9JKF1-9-unmodified	GLGVVR...	9			unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
Q9JKF1-9-unmodified	GLGVVR...	9			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q9JKF1-11-unmodified	GVVRPH...	11			unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
Q9JKF1-16-unknown	HYGSVL...	16		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34310
Q9JKF1-575-unknown	VAQHYQ...	575		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34311
Q9JKF1-627-unmodified	ISAINE...	627			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
Q9JKF1-630-unknown	INEAVD...	630		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31190
Q9JKF1-950-unknown	MINKQK...	950		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31191
Q9JKF1-951-unknown	INKQKG...	951		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31192
Q9JKF1-1212-unknown	SAGGQL...	1212		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31193
Q9JKF1-1481-unknown	LINDIA...	1481		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31194
Q9JKF1-1482-unknown	INDIAK...	1482		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31195
Q9JKF1-1531-unknown	IKTCLD...	1531		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31196
Q9JKF1-1535-unknown	LDNLAS...	1535		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31197
Q9JKF1-1539-unknown	ASKGKV...	1539		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31198

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVVRPH	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34310
...GVLAEV	574	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34311
...LGISAI	629	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31190
...LSDMMM	949	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31191
...SDMMMI	950	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31192
...DIIDLS	1211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31193
...NRYQEL	1480	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31194
...RYQELI	1481	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31195
...YYKSYI	1530	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31196
...YIKTCL	1534	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31197
...CLDNLA	1538	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31198
...KFYGK	1657	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	15	VRPH.\|.HYGS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	574	LAEV.\|.VAQH	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	629	ISAI.\|.INEA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IQGA1_MOUSE @629
CATE_MOUSE	949	DMMM.\|.MINK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IQGA1_MOUSE @949
CATE_MOUSE	950	MMMI.\|.INKQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IQGA1_MOUSE @950
CATE_MOUSE	1211	IDLS.\|.SAGG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IQGA1_MOUSE @1211
CATE_MOUSE	1480	YQEL.\|.LIND	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IQGA1_MOUSE @1480
CATE_MOUSE	1481	QELI.\|.INDI	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IQGA1_MOUSE @1481
CATE_MOUSE	1530	KSYI.\|.IKTC	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IQGA1_MOUSE @1530
CATE_MOUSE	1534	KTCL.\|.LDNL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IQGA1_MOUSE @1534
CATE_MOUSE	1538	DNLA.\|.ASKG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IQGA1_MOUSE @1538

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)