P07214: SPARC

General Information

Protein names	- SPARC - Basement-membrane protein 40 - BM-40 - Osteonectin - ON - Secreted protein acidic and rich in cysteine
Gene names	Sparc
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P07214

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRAWIFFLLC LAGRALAAPQ QTEVAEEIVE EETVVEETGV PVGANPVQVE MGEFEDGAEE
        70         80         90        100        110        120
TVEEVVADNP CQNHHCKHGK VCELDESNTP MCVCQDPTSC PAPIGEFEKV CSNDNKTFDS
       130        140        150        160        170        180
SCHFFATKCT LEGTKKGHKL HLDYIGPCKY IAPCLDSELT EFPLRMRDWL KNVLVTLYER
       190        200        210        220        230        240
DEGNNLLTEK QKLRVKKIHE NEKRLEAGDH PVELLARDFE KNYNMYIFPV HWQFGQLDQH
       250        260        270        280        290        300
PIDGYLSHTE LAPLRAPLIP MEHCTTRFFE TCDLDNDKYI ALEEWAGCFG IKEQDINKDL

VI

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P07214-18-unknown	APQQTE...	18		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07214-155-unknown	LDSELT...	155			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P07214-155-unmodified	LDSELT...	155			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P07214-181-acetylation	DEGNNL...	181	acetylation-		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P07214-205-unknown	LEAGDH...	205		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33241

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LKNVLV	174	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000119475
...ENEKRL	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33241
...KDLVI	302	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	204	EKRL.\|.LEAG	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)