P48678: Prelamin-A/C
Protein names | - Prelamin-A/C - Lamin-A/C |
---|---|
Gene names | Lmna |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P48678 |
5
N-termini
5
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR
70 80 90 100 110 120
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN
130 140 150 160 170 180
TKKEGDLLAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK
190 200 210 220 230 240
KQLQDEMLRR VDAENRLQTL KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR
250 260 270 280 290 300
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
310 320 330 340 350 360
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ
370 380 390 400 410 420
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQSQ GGGSVTKKRK
430 440 450 460 470 480
LESSESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIR RQNGDDPLMT
490 500 510 520 530 540
YRFPPKFTLK AGQVVTIWAS GAGATHSPPT DLVWKAQNTW GCGSSLRTAL INSTGEEVAM
550 560 570 580 590 600
RKLVRSLTMV EDNEDDDEDG EELLHHHRGS HCSGSGDPAE YNLRSRTVLC GTCGQPADKA
610 620 630 640 650 660
AGGAGAQVGG SISSGSSASS VTVTRSFRSV GGSGGGSFGD NLVTRSYLLG NSSPRSQSSQ
NCSIM
Isoforms
- Isoform C of Prelamin-A/C - Isoform C2 of Prelamin-A/CSequence View
10 20 30 40 50 60
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR
70 80 90 100 110 120
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN
130 140 150 160 170 180
TKKEGDLLAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK
190 200 210 220 230 240
KQLQDEMLRR VDAENRLQTL KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR
250 260 270 280 290 300
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
310 320 330 340 350 360
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ
370 380 390 400 410 420
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQSQ GGGSVTKKRK
430 440 450 460 470 480
LESSESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIR RQNGDDPLMT
490 500 510 520 530 540
YRFPPKFTLK AGQVVTIWAS GAGATHSPPT DLVWKAQNTW GCGSSLRTAL INSTGEEVAM
550 560 570 580 590 600
RKLVRSLTMV EDNEDDDEDG EELLHHHRGS HCSGSGDPAE YNLRSRTVLC GTCGQPADKA
610 620 630 640 650 660
AGGAGAQVGG SISSGSSASS VTVTRSFRSV GGSGGGSFGD NLVTRSYLLG NSSPRSQSSQ
NCSIM
10 20 30 40 50 60
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR
70 80 90 100 110 120
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN
130 140 150 160 170 180
TKKEGDLLAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK
190 200 210 220 230 240
KQLQDEMLRR VDAENRLQTL KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR
250 260 270 280 290 300
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
310 320 330 340 350 360
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ
370 380 390 400 410 420
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQSQ GGGSVTKKRK
430 440 450 460 470 480
LESSESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIR RQNGDDPLMT
490 500 510 520 530 540
YRFPPKFTLK AGQVVTIWAS GAGATHSPPT DLVWKAQNTW GCGSSLRTAL INSTGEEVAM
550 560 570 580 590 600
RKLVRSLTMV EDNEDDDEDG EELLHHHRGS HCSGSGDPAE YNLRSRTVLC GTCGQPADKA
610 620 630 640 650 660
AGGAGAQVGG SISSGSSASS VTVTRSFRSV GGSGGGSFGD NLVTRSYLLG NSSPRSQSSQ
NCSIM
Protein Neighborhood
Domains & Features
5 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P48678-1-Acetylation | METPSQ... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P48678-1-Acetylation | METPSQ... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt97399 | ||
P48678-1-unknown | METPSQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt79742 | |||
P48678-35-unknown | LQELND... | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30002 | |||
P48678-35-unknown | LQELND... | 35 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137950 | |||
P48678-284-unknown | LVGAAH... | 284 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33582 | |||
P48678-284-unknown | LVGAAH... | 284 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145583 | |||
P48678-284-unknown | LVGAAH... | 284 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149442 | |||
P48678-309-unknown | LQKQLA... | 309 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33585 | |||
P48678-309-unknown | LQKQLA... | 309 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146487 | |||
P48678-309-unknown | LQKQLA... | 309 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150097 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...QEKEDL | 34 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30002 | |||
...QEKEDL | 34 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120959 | |||
...ERNSNL | 283 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33582 | |||
...ERNSNL | 283 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt128881 | |||
...ERNSNL | 283 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132827 | |||
...AQLSQL | 308 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33585 | |||
...AQLSQL | 308 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129795 | |||
...AQLSQL | 308 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133489 | |||
...VTRSYL | 647 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SSQNCS | 662 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATE_MOUSE | 34 | KEDL.|.LQEL | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> LMNA_MOUSE @34 | ||
MMP2_MOUSE | 283 | NSNL.|.LVGA | inferred from experiment | unknown | MEROPS | Merops MMP2_MOUSE -> LMNA_MOUSE @283 | ||
MMP2_MOUSE | 308 | LSQL.|.LQKQ | inferred from experiment | unknown | MEROPS | Merops MMP2_MOUSE -> LMNA_MOUSE @308 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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