P09405: Nucleolin

General Information

Protein names	- Nucleolin - Protein C23
Gene names	Ncl
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P09405

17 N-termini

15 C-termini

14 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVKLAKAGKT HGEAKKMAPP PKEVEEDSED EEMSEDEDDS SGEEEVVIPQ KKGKKATTTP
        70         80         90        100        110        120
AKKVVVSQTK KAAVPTPAKK AAVTPGKKAV ATPAKKNITP AKVIPTPGKK GAAQAKALVP
       130        140        150        160        170        180
TPGKKGAATP AKGAKNGKNA KKEDSDEDED EEDEDDSDED EDDEEEDEFE PPIVKGVKPA
       190        200        210        220        230        240
KAAPAAPASE DEEDDEDEDD EEDDDEEEED DSEEEVMEIT TAKGKKTPAK VVPMKAKSVA
       250        260        270        280        290        300
EEEDDEEEDE DDEDEDDEEE DDEDDDEEEE EEEPVKAAPG KRKKEMTKQK EAPEAKKQKV
       310        320        330        340        350        360
EGSEPTTPFN LFIGNLNPNK SVNELKFAIS ELFAKNDLAV VDVRTGTNRK FGYVDFESAE
       370        380        390        400        410        420
DLEKALELTG LKVFGNEIKL EKPKGRDSKK VRAARTLLAK NLSFNITEDE LKEVFEDAME
       430        440        450        460        470        480
IRLVSQDGKS KGIAYIEFKS EADAEKNLEE KQGAEIDGRS VSLYYTGEKG QRQERTGKTS
       490        500        510        520        530        540
TWSGESKTLV LSNLSYSATK ETLEEVFEKA TFIKVPQNPH GKPKGYAFIE FASFEDAKEA
       550        560        570        580        590        600
LNSCNKMEIE GRTIRLELQG SNSRSQPSKT LFVKGLSEDT TEETLKESFE GSVRARIVTD
       610        620        630        640        650        660
RETGSSKGFG FVDFNSEEDA KAAKEAMEDG EIDGNKVTLD WAKPKGEGGF GGRGGGRGGF
       670        680        690        700
GGRGGGRGGR GGFGGRGRGG FGGRGGFRGG RGGGGDFKPQ GKKTKFE

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

17 N-termini - 15 C-termini - 14 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P09405-2-unknown	VKLAKA...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09405-2-unknown	VKLAKA...	2	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P09405-63-unknown	KVVVSQ...	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33286
P09405-262-unknown	DEDDDE...	262	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32301
P09405-329-unmodified	ISELFA...	329		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P09405-332-unknown	LFAKND...	332	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33287
P09405-336-unknown	NDLAVV...	336	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33288
P09405-368-unknown	LTGLKV...	368	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33289
P09405-410-unknown	ELKEVF...	410	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32302
P09405-436-unknown	IEFKSE...	436	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33290
P09405-439-unknown	KSEADA...	439	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32607
P09405-444-unknown	AEKNLE...	444	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32303
P09405-529-unknown	IEFASF...	529	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33291
P09405-534-unknown	FEDAKE...	534	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33292
P09405-541-unknown	LNSCNK...	541	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33293
P09405-575-unmodified	GLSEDT...	575		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P09405-576-unknown	LSEDTT...	576	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33294
P09405-580-unknown	TTEETL...	580	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32304

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TTPAKK	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33286
...DEEEDD	261	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32301
...FAISEL	331	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33287
...ELFAKN	335	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33288
...EKALEL	367	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33289
...NITEDE	409	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32302
...KGIAYI	435	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33290
...AYIEFK	438	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32607
...KSEADA	443	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32303
...KGYAFI	528	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33291
...IEFASF	533	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33292
...DAKEAL	540	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33293
...LFVKGL	575	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33294
...GLSEDT	579	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32304
...KTKFE	707	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	62	PAKK.\|.KVVV	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> NUCL_MOUSE @62
GRAB_MOUSE	261	EEDD.\|.DEDD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MMP2_MOUSE	331	ISEL.\|.LFAK	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	335	FAKN.\|.NDLA	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	367	ALEL.\|.LTGL	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
GRAB_MOUSE	409	TEDE.\|.ELKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MMP2_MOUSE	435	IAYI.\|.IEFK	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
GRAC_MOUSE	438	IEFK.\|.KSEA	inferred from experiment	unknown	MEROPS	Bird PI	Kaiserman D et al.:Structure of granzyme C reveals... (S01.137)	19299505,
GRAB_MOUSE	443	EADA.\|.AEKN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MMP2_MOUSE	528	YAFI.\|.IEFA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	533	FASF.\|.FEDA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	540	KEAL.\|.LNSC	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	575	VKGL.\|.LSED	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
GRAB_MOUSE	579	SEDT.\|.TTEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)