Q01149: Collagen alpha-2(I) chain

General Information

Protein names	- Collagen alpha-2(I) chain - Alpha-2 type I collagen
Gene names	Col1a2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01149

15 N-termini

11 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLSFVDTRTL LLLAVTSCLA TCQYLQSGSV RKGPTGDRGP RGQRGPAGPR GRDGVDGPMG
        70         80         90        100        110        120
PPGPPGSPGP PGSPAPPGLT GNFAAQYSDK GVSSGPGPMG LMGPRGPPGA VGAPGPQGFQ
       130        140        150        160        170        180
GPAGEPGEPG QTGPAGPRGP AGSPGKAGED GHPGKPGRPG ERGVVGPQGA RGFPGTPGLP
       190        200        210        220        230        240
GFKGVKGHSG MDGLKGQPGA QGVKGEPGAP GENGTPGQAG ARGLPGERGR VGAPGPAGAR
       250        260        270        280        290        300
GSDGSVGPVG PAGPIGSAGP PGFPGAPGPK GELGPVGNPG PAGPAGPRGE VGLPGLSGPV
       310        320        330        340        350        360
GPPGNPGTNG LTGAKGATGL PGVAGAPGLP GPRGIPGPAG AAGATGARGL VGEPGPAGSK
       370        380        390        400        410        420
GESGNKGEPG SVGAQGPPGP SGEEGKRGSP GEAGSAGPAG PPGLRGSPGS RGLPGADGRA
       430        440        450        460        470        480
GVMGPPGNRG STGPAGIRGP NGDAGRPGEP GLMGPRGLPG SPGNVGPSGK EGPVGLPGID
       490        500        510        520        530        540
GRPGPIGPAG PRGEAGNIGF PGPKGPSGDP GKPGERGHPG LAGARGAPGP DGNNGAQGPP
       550        560        570        580        590        600
GPQGVQGGKG EQGPAGPPGF QGLPGPSGTT GEVGKPGERG LPGEFGLPGP AGPRGERGTP
       610        620        630        640        650        660
GESGAAGPSG PIGSRGPSGA PGPDGNKGEA GAVGAPGSAG ASGPGGLPGE RGAAGIPGGK
       670        680        690        700        710        720
GEKGETGLRG DTGNTGRDGA RGIPGAVGAP GPAGASGDRG EAGAAGPSGP AGPRGSPGER
       730        740        750        760        770        780
GEVGPAGPNG FAGPAGAAGQ PGAKGEKGTK GPKGENGIVG PTGSVGAAGP SGPNGPPGPV
       790        800        810        820        830        840
GSRGDGGPPG MTGFPGAAGR TGPPGPSGIA GPPGPPGAAG KEGIRGPRGD QGPVGRTGET
       850        860        870        880        890        900
GASGPPGFVG EKGPSGEPGT AGAPGTAGPQ GLLGAPGILG LPGSRGERGL PGIAGALGEP
       910        920        930        940        950        960
GPLGISGPPG ARGPPGAVGS PGVNGAPGEA GRDGNPGSDG PPGRDGQPGH KGERGYPGSI
       970        980        990       1000       1010       1020
GPTGAAGAPG PHGSVGPAGK HGNRGEPGPA GSVGPVGAVG PRGPSGPQGI RGDKGEPGDK
      1030       1040       1050       1060       1070       1080
GHRGLPGLKG YSGLQGLPGL AGLHGDQGAP GPVGPAGPRG PAGPSGPVGK DGRSGQPGPV
      1090       1100       1110       1120       1130       1140
GPAGVRGSQG SQGPAGPPGP PGPPGPPGVS GGGYDFGFEG DFYRADQPRS QPSLRPKDYE
      1150       1160       1170       1180       1190       1200
VDATLKSLNN QIETLLTPEG SRKNPARTCR DLRLSHPEWN SDYYWIDPNQ GCTMDAIKVY
      1210       1220       1230       1240       1250       1260
CDFSTGETCI QAQPVNTPAK NSYSRAQANK HVWLGETING GSQFEYNVEG VSSKEMATQL
      1270       1280       1290       1300       1310       1320
AFMRLLANRA SQNITYHCKN SIAYLDEETG SLNKAVLLQG SNDVELVAEG NSRFTYSVLV
      1330       1340       1350       1360       1370
DGCSKKTNEW GKTIIEYKTN KPSRLPFLDI APLDIGGADQ EFRVEVGPVC FK

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 11 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01149-23-unknown	QYLQSG...	23	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01149-86-unknown	QYSDKG...	86	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01149-86-unknown	QYSDKG...	86	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q01149-257-unknown	SAGPPG...	257	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33851
Q01149-272-unknown	ELGPVG...	272	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33852
Q01149-391-unknown	GEAGSA...	391	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q01149-437-unknown	IRGPNG...	437	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33853
Q01149-560-unmodified	FQGLPG...	560		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
Q01149-764-unknown	SVGAAG...	764	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33854
Q01149-791-unknown	MTGFPG...	791	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33855
Q01149-809-unknown	IAGPPG...	809	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33856
Q01149-809-unknown	IAGPPG...	809	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34630
Q01149-848-unknown	FVGEKG...	848	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33857
Q01149-1043-unknown	LHGDQG...	1043	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33858
Q01149-1109-unknown	VSGGGY...	1109	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33859
Q01149-1147-unmodified	SLNNQI...	1147		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
Q01149-1148-unknown	LNNQIE...	1148	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33860

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FPGTPG	177	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000125275
...AGPIGS	256	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33851
...PGPKGE	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33852
...TGPAGI	436	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33853
...VGPTGS	763	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33854
...GGPPGM	790	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33855
...PGPSGI	808	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33856
...PGPSGI	808	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34630
...SGPPGF	847	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33857
...PGLAGL	1042	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33858
...PGPPGV	1108	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PGPPGV	1108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33859
...PGPPGV	1108	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
...ATLKSL	1147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33860

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	256	PIGS.\|.SAGP	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CO1A2_MOUSE @256
MMP2_MOUSE	271	PKGE.\|.ELGP	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CO1A2_MOUSE @271
MMP2_MOUSE	436	PAGI.\|.IRGP	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CO1A2_MOUSE @436
MMP2_MOUSE	763	PTGS.\|.SVGA	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CO1A2_MOUSE @763
MMP2_MOUSE	790	PPGM.\|.MTGF	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CO1A2_MOUSE @790
MMP2_MOUSE	808	PSGI.\|.IAGP	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP9_MOUSE	808	PSGI.\|.IAGP	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	847	PPGF.\|.FVGE	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CO1A2_MOUSE @847
MMP2_MOUSE	1042	LAGL.\|.LHGD	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	1108	PPGV.\|.VSGG	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CO1A2_MOUSE @1108
MMP2_MOUSE	1147	LKSL.\|.LNNQ	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CO1A2_MOUSE @1147

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)