P31001: Desmin

General Information

Protein names	- Desmin
Gene names	Des
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P31001

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSQAYSSSQR VSSYRRTFGG APGFSLGSPL SSPVFPRAGF GTKGSSSSMT SRVYQVSRTS
        70         80         90        100        110        120
GGAGGLGSLR SSRLGTTRAP SYGAGELLDF SLADAVNQEF LATRTNEKVE LQELNDRFAN
       130        140        150        160        170        180
YIEKVRFLEQ QNAALAAEVN RLKGREPTRV AELYEEEMRE LRRQVEVLTN QRARVDVERD
       190        200        210        220        230        240
NLIDDLQRLK AKLQEEIQLR EEAENNLAAF RADVDAATLA RIDLERRIES LNEEIAFLKK
       250        260        270        280        290        300
VHEEEIRELQ AQLQEQQVQV EMDMSKPDLT AALRDIRAQY ETIAAKNISE AEEWYKSKVS
       310        320        330        340        350        360
DLTQAANKNN DALRQAKQEM MEYRHQIQSY TCEIDALKGT NDSLMRQMRE LEDRFASEAN
       370        380        390        400        410        420
GYQDNIARLE EEIRHLKDEM ARHLREYQDL LNVKMALDVE IATYRKLLEG EESRINLPIQ
       430        440        450        460
TFSALNFRET SPEQRGSEVH TKKTVMIKTI ETRDGEVVSE ATQQQHEVL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P31001-1-unknown	MSQAYS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31001-107-unmodified	EKVELQ...	107		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P31001-111-unknown	LQELND...	111	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29920
P31001-150-unknown	VAELYE...	150	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33525
P31001-264-unknown	MSKPDL...	264	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28529

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NEKVEL	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29920
...REPTRV	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33525
...QVEMDM	263	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28529
...QHEVL	469	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	110	KVEL.\|.LQEL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> DESM_MOUSE @110
MMP2_MOUSE	149	PTRV.\|.VAEL	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> DESM_MOUSE @149
CASP6_MOUSE	263	EMDM.\|.MSKP	inferred from experiment	unknown	MEROPS	Cryns VL	Chen F et al.:Caspase proteolysis of desmin p... (C14.005)	12477713,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)