O70435: Proteasome subunit alpha type-3

General Information

Protein names	- Proteasome subunit alpha type-3 - 3.4.25.1 {ECO:0000250\|UniProtKB:P25788} - Macropain subunit C8 - Multicatalytic endopeptidase complex subunit C8 - Proteasome component C8 - Proteasome subunit K
Gene names	Psma3
Organism	Mus musculus
Protease Family
Protease ID	T01.977
Chromosome location
UniProt ID	O70435

7 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSIGTGYDL SASTFSPDGR VFQVEYAMKA VENSSTAIGI RCKDGVVFGV EKLVLSKLYE
        70         80         90        100        110        120
EGSNKRLFNV DRHVGMAVAG LLADARSLAD IAREEASNFR SNFGYNIPLK HLADRVAMYV
       130        140        150        160        170        180
HAYTLYSAVR PFGCSFMLGS YSANDGAQLY MIDPSGVSYG YWGCAIGKAR QAAKTEIEKL
       190        200        210        220        230        240
QMKEMTCRDV VKEVAKIIYI VHDEVKDKAF ELELSWVGEL TKGRHEIVPK DIREEAEKYA
       250
KESLKEEDES DDDNM

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
O70435-2-unknown	MSSIGT...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O70435-2-Acetylation	SSIGTG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O70435-11-unknown	SASTFS...	11		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29563
O70435-13-unknown	STFSPD...	13		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33163
O70435-18-unknown	DGRVFQ...	18		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
O70435-58-unknown	LYEEGS...	58		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33164
O70435-76-unknown	MAVAGL...	76		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000124894

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TGYDLS	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29563
...YDLSAS	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33163
...LVLSKL	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33164
...DDDNM	255	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	10	YDLS.\|.SAST	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PSA3_MOUSE @10
MMP2_MOUSE	12	LSAS.\|.STFS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	57	LSKL.\|.LYEE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)