P58389: Serine/threonine-protein phosphatase 2A activator

General Information

Protein names	- Serine/threonine-protein phosphatase 2A activator - 5.2.1.8 - PP2A, subunit B', PR53 isoform - Phosphotyrosyl phosphatase activator - PTPA - Serine/threonine-protein phosphatase 2A regulatory subunit 4 - Serine/threonine-protein phosphatase 2A regulatory subunit B'
Gene names	Ppp2r4
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P58389

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEGERQPPP DSSEETPPTT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG FILTLNEGVK
        70         80         90        100        110        120
GKKLTFDYKV SEAIEKLVAL LDTLDRWIDE TPPVDQPSRF GNKAYRTWYA KLDQEAENLV
       130        140        150        160        170        180
ATVVPTHLAA AVPEVAVYLK EAVGNSTRID YGTGHEAAFA AFLCCLCKIG VLRVDDQVAI
       190        200        210        220        230        240
VFKVFDRYLE VMRKLQKTYR MEPAGSQGVW GLDDFQFLPF IWGSSQLIDH PHLEPRHFVD
       250        260        270        280        290        300
EKAVSENHKD YMFLQCILFI TEMKTGPFAE HSNQLWNISA VPSWSKVNQG LIRMYKAECL
       310        320
EKFPVIQHFK FGSLLPIHPV TSG

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P58389-2-unknown	MAEGER...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P58389-2-unknown	MAEGER...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P58389-2-Acetylation	AEGERQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P58389-2-Acetylation	AEGERQ...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P58389-137-unknown	VYLKEA...	137		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30118
P58389-227-unknown	LIDHPH...	227		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33647
P58389-263-unknown	MKTGPF...	263		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000114985
P58389-263-unknown	MKTGPF...	263		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000116268

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VPEVAV	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30118
...WGSSQL	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33647
...PVTSG	323	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	136	EVAV.\|.VYLK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PTPA_MOUSE @136
MMP2_MOUSE	226	SSQL.\|.LIDH	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)