Q62318: Transcription intermediary factor 1-beta

General Information

Protein names	- Transcription intermediary factor 1-beta - TIF1-beta - E3 SUMO-protein ligase TRIM28 - 2.3.2.27 - KRAB-A-interacting protein - KRIP-1 - RING-type E3 ubiquitin transferase TIF1-beta {ECO:0000305} - Tripartite motif-containing protein 28
Gene names	Trim28
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q62318

9 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAASAAATAA ASAATAASAA SGSPGSGEGS AGGEKRPAAS SAAAASAAAS SPAGGGGEAQ
        70         80         90        100        110        120
ELLEHCGVCR ERLRPERDPR LLPCLHSACS ACLGPATPAA ANNSGDGGSA GDGAMVDCPV
       130        140        150        160        170        180
CKQQCYSKDI VENYFMRDSG SKASSDSQDA NQCCTSCEDN APATSYCVEC SEPLCETCVE
       190        200        210        220        230        240
AHQRVKYTKD HTVRSTGPAK TRDGERTVYC NVHKHEPLVL FCESCDTLTC RDCQLNAHKD
       250        260        270        280        290        300
HQYQFLEDAV RNQRKLLASL VKRLGDKHAT LQKNTKEVRS SIRQVSDVQK RVQVDVKMAI
       310        320        330        340        350        360
LQIMKELNKR GRVLVNDAQK VTEGQQERLE RQHWTMTKIQ KHQEHILRFA SWALESDNNT
       370        380        390        400        410        420
ALLLSKKLIY FQLHRALKMI VDPVEPHGEM KFQWDLNAWT KSAEAFGKIV AERPGTNSTG
       430        440        450        460        470        480
PGPMAPPRAP GPLSKQGSGS SQPMEVQEGY GFGSDDPYSS AEPHVSGMKR SRSGEGEVSG
       490        500        510        520        530        540
LLRKVPRVSL ERLDLDLTSD SQPPVFKVFP GSTTEDYNLI VIERGAAAAA AGQAGTVPPG
       550        560        570        580        590        600
APGAPPLPGM AIVKEEETEA AIGAPPAAPE GPETKPVLMP LTEGPGAEGP RLASPSGSTS
       610        620        630        640        650        660
SGLEVVAPEV TSAPVSGPGI LDDSATICRV CQKPGDLVMC NQCEFCFHLD CHLPALQDVP
       670        680        690        700        710        720
GEEWSCSLCH VLPDLKEEDG SLSLDGADST GVVAKLSPAN QRKCERVLLA LFCHEPCRPL
       730        740        750        760        770        780
HQLATDSTFS MEQPGGTLDL TLIRARLQEK LSPPYSSPQE FAQDVGRMFK QFNKLTEDKA
       790        800        810        820        830
DVQSIIGLQR FFETRMNDAF GDTKFSAVLV EPPPLNLPSA GLSSQELSGP GDGP

Isoforms

- Isoform 2 of Transcription intermediary factor 1-beta

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q62318-1-unknown	MAASAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92164
Q62318-2-unknown	MAASAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q62318-2-Acetylation	AASAAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q62318-2-Acetylation	AASAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110473
Q62318-221-unknown	FCESCD...	221		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30541
Q62318-221-unknown	FCESCD...	221		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147382
Q62318-313-unknown	VLVNDA...	313			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
Q62318-313-unknown	VLVNDA...	313		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160513
Q62318-581-unknown	LTEGPG...	581		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33987
Q62318-686-unknown	GADSTG...	686		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28389
Q62318-733-unknown	QPGGTL...	733		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28390
Q62318-735-unknown	GGTLDL...	735		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28391

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EPLVLF	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30541
...EPLVLF	220	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130729
...PVLMPL	580	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33987
...SLSLDG	685	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28389
...TFSMEQ	732	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28390
...SMEQPG	734	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28391
...PGDGP	834	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	220	LVLF.\|.FCES	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TIF1B_MOUSE @220
MMP2_MOUSE	580	LMPL.\|.LTEG	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CASP1_MOUSE	685	SLDG.\|.GADS	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CASP1_MOUSE	732	SMEQ.\|.QPGG	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
CASP1_MOUSE	734	EQPG.\|.GGTL	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)