O08677: Kininogen-1

General Information

Protein names	- Kininogen-1 - Kininogen-1 heavy chain - Bradykinin - Kininogen-1 light chain
Gene names	Kng1
Organism	Mus musculus
Protease Family
Protease ID	I25.017
Chromosome location
UniProt ID	O08677

6 N-termini

5 C-termini

7 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform LMW of Kininogen-1 - Isoform 3 of Kininogen-1

Sequence View

        10         20         30         40         50         60
MKLITTLLLC SGLLLTLTQG EEAQEIDCND EAVFQAVDFS LKQFNPGVKS GNQYMLHRVI
        70         80         90        100        110        120
EGTKTDGSPT FYSFKYLIKE GNCSAQSGLA WQDCDFKDAE EAATGECTAT VGKRENEFFI
       130        140        150        160        170        180
VTQTCKIAPS KAPILKAYFP CIGCVHAIST DSPDLEPVLK HSIEHFNNNT DHSHLFTLRK
       190        200        210        220        230        240
VKSAHRQVVA GLNFDITYTI VQTNCSKERF PSLHGDCVAL PNGDDGECRG NLFMDINNKI
       250        260        270        280        290        300
ANFSQSCTLY SGDDLVEALP KPCPGCPRDI PVDSPELKEV LGHSIAQLNA ENDHPFYYKI
       310        320        330        340        350        360
DTVKKATSQV VAGTKYVIEF IARETKCSKE SNTELAEDCE IKHLGQSLDC NANVYMRPWE
       370        380        390        400        410        420
NKVVPTVKCQ ALDMTEMARR PPGFSPFRSV TVQETKEGRT VSPPYIAREQ EERDAETEQG
       430        440        450        460        470        480
PTHGHGWLHE KQIKANKNHR GHKHGHDHGH WSPRRHGLGH GHQKPHGLGH GHQLKLDYLR
       490        500        510        520        530        540
HQREDGDDHT HTVGHGHGHG HGHGHGHGHG HGHGHGHGHG HGHGKHTNKD KNSVKQTTQR
       550        560        570        580        590        600
TESLASSSEY STTSTQMQGR TEGPTLTPPR AQPTVTSSGF QDSDFIEDVV ATTPPYDTGA
       610        620        630        640        650        660
HDDLIPDIHV QPDSLSFKLI SDFPEATSPK CPGRPWKPAS WEDPNTETTE FSDFDLLDAL

S         10         20         30         40         50         60
MKLITTLLLC SGLLLTLTQG EEAQEIDCND EAVFQAVDFS LKQFNPGVKS GNQYMLHRVI
        70         80         90        100        110        120
EGTKTDGSPT FYSFKYLIKE GNCSAQSGLA WQDCDFKDAE EAATGECTAT VGKRENEFFI
       130        140        150        160        170        180
VTQTCKIAPS KAPILKAYFP CIGCVHAIST DSPDLEPVLK HSIEHFNNNT DHSHLFTLRK
       190        200        210        220        230        240
VKSAHRQVVA GLNFDITYTI VQTNCSKERF PSLHGDCVAL PNGDDGECRG NLFMDINNKI
       250        260        270        280        290        300
ANFSQSCTLY SGDDLVEALP KPCPGCPRDI PVDSPELKEV LGHSIAQLNA ENDHPFYYKI
       310        320        330        340        350        360
DTVKKATSQV VAGTKYVIEF IARETKCSKE SNTELAEDCE IKHLGQSLDC NANVYMRPWE
       370        380        390        400        410        420
NKVVPTVKCQ ALDMTEMARR PPGFSPFRSV TVQETKEGRT VSPPYIAREQ EERDAETEQG
       430        440        450        460        470        480
PTHGHGWLHE KQIKANKNHR GHKHGHDHGH WSPRRHGLGH GHQKPHGLGH GHQLKLDYLR
       490        500        510        520        530        540
HQREDGDDHT HTVGHGHGHG HGHGHGHGHG HGHGHGHGHG HGHGKHTNKD KNSVKQTTQR
       550        560        570        580        590        600
TESLASSSEY STTSTQMQGR TEGPTLTPPR AQPTVTSSGF QDSDFIEDVV ATTPPYDTGA
       610        620        630        640        650        660
HDDLIPDIHV QPDSLSFKLI SDFPEATSPK CPGRPWKPAS WEDPNTETTE FSDFDLLDAL

S

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O08677-1-unknown	MKLITT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79197
O08677-1-unknown	MKLITT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79198
O08677-21-unknown	EEAQEI...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O08677-21-unknown	EEAQEI...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112766
O08677-21-unknown	EEAQEI...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112767
O08677-55-unknown	MLHRVI...	55	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000121701
O08677-55-unknown	MLHRVI...	55	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133664
O08677-55-unknown	MLHRVI...	55	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt133665
O08677-380-unknown	RPPGFS...	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32650
O08677-380-unknown	RPPGFS...	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32656
O08677-380-unknown	RPPGFS...	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32666
O08677-380-unknown	RPPGFS...	380	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151616
O08677-380-unknown	RPPGFS...	380	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151617
O08677-387-unknown	FRSVTV...	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27815
O08677-389-unknown	SVTVQE...	389	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O08677-389-unknown	SVTVQE...	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32653
O08677-389-unknown	SVTVQE...	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32659
O08677-389-unknown	SVTVQE...	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32669

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SAHRQV	187	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000121701
...SAHRQV	187	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt117259
...SAHRQV	187	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt117260
...TEMARR	379	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TEMARR	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32650
...TEMARR	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32656
...TEMARR	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32666
...TEMARR	379	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92594
...TEMARR	379	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92595
...PGFSPF	386	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27815
...PGFSPF	386	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135188
...PGFSPF	386	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135189
...FSPFRS	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32653
...FSPFRS	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32659
...FSPFRS	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32669
...FSPFRS	388	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135230
...FSPFRS	388	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135231
...LDALS	661	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LDALS	661	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74816

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
K1KB1_MOUSE	379	MARR.\|.RPPG	inferred from experiment	unknown	MEROPS		Merops K1KB1_MOUSE -> KNG1_MOUSE @379
K1KB9_MOUSE	379	MARR.\|.RPPG	inferred from experiment	unknown	MEROPS		Merops K1KB9_MOUSE -> KNG1_MOUSE @379
KLK1_MOUSE	379	MARR.\|.RPPG	inferred from experiment	unknown	MEROPS		Merops KLK1_MOUSE -> KNG1_MOUSE @379
ACE2_MOUSE	386	FSPF.\|.FRSV	inferred from experiment	unknown	MEROPS	Acton S	Donoghue M et al.:A novel angiotensin-converting ... (M02.006)	10969042,
K1KB1_MOUSE	388	PFRS.\|.SVTV	inferred from experiment	unknown	MEROPS		Merops K1KB1_MOUSE -> KNG1_MOUSE @388
K1KB9_MOUSE	388	PFRS.\|.SVTV	inferred from experiment	unknown	MEROPS		Merops K1KB9_MOUSE -> KNG1_MOUSE @388
KLK1_MOUSE	388	PFRS.\|.SVTV	inferred from experiment	unknown	MEROPS		Merops KLK1_MOUSE -> KNG1_MOUSE @388

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)