TopFIND 4.0

Q8R0I0: Angiotensin-converting enzyme 2

General Information

Protein names
- Angiotensin-converting enzyme 2
- 3.4.17.23
- ACE-related carboxypeptidase
- Processed angiotensin-converting enzyme 2
Gene names Ace2
Organism Mus musculus
Protease Family M02.006
Protease ID M02.006
Chromosome location
UniProt ID Q8R0I0

2

N-termini

3

C-termini

0

Cleavages

3

Substrates

Sequence

        10         20         30         40         50         60 
MSSSSWLLLS LVAVTTAQSL TEENAKTFLN NFNQEAEDLS YQSSLASWNY NTNITEENAQ 
        70         80         90        100        110        120 
KMSEAAAKWS AFYEEQSKTA QSFSLQEIQT PIIKRQLQAL QQSGSSALSA DKNKQLNTIL 
       130        140        150        160        170        180 
NTMSTIYSTG KVCNPKNPQE CLLLEPGLDE IMATSTDYNS RLWAWEGWRA EVGKQLRPLY 
       190        200        210        220        230        240 
EEYVVLKNEM ARANNYNDYG DYWRGDYEAE GADGYNYNRN QLIEDVERTF AEIKPLYEHL 
       250        260        270        280        290        300 
HAYVRRKLMD TYPSYISPTG CLPAHLLGDM WGRFWTNLYP LTVPFAQKPN IDVTDAMMNQ 
       310        320        330        340        350        360 
GWDAERIFQE AEKFFVSVGL PHMTQGFWAN SMLTEPADGR KVVCHPTAWD LGHGDFRIKM 
       370        380        390        400        410        420 
CTKVTMDNFL TAHHEMGHIQ YDMAYARQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS 
       430        440        450        460        470        480 
IGLLPSDFQE DSETEINFLL KQALTIVGTL PFTYMLEKWR WMVFRGEIPK EQWMKKWWEM 
       490        500        510        520        530        540 
KREIVGVVEP LPHDETYCDP ASLFHVSNDY SFIRYYTRTI YQFQFQEALC QAAKYNGSLH 
       550        560        570        580        590        600 
KCDISNSTEA GQKLLKMLSL GNSEPWTKAL ENVVGARNMD VKPLLNYFQP LFDWLKEQNR 
       610        620        630        640        650        660 
NSFVGWNTEW SPYADQSIKV RISLKSALGA NAYEWTNNEM FLFRSSVAYA MRKYFSIIKN 
       670        680        690        700        710        720 
QTVPFLEEDV RVSDLKPRVS FYFFVTSPQN VSDVIPRSEV EDAIRMSRGR INDVFGLNDN 
       730        740        750        760        770        780 
SLEFLGIHPT LEPPYQPPVT IWLIIFGVVM ALVVVGIIIL IVTGIKGRKK KNETKREENP 
       790        800    
YDSMDIGKGE SNAGFQNSDD AQTSF

Isoforms

- Isoform 2 of Angiotensin-converting enzyme 2

Sequence View

        10         20         30         40         50         60 
MSSSSWLLLS LVAVTTAQSL TEENAKTFLN NFNQEAEDLS YQSSLASWNY NTNITEENAQ 
        70         80         90        100        110        120 
KMSEAAAKWS AFYEEQSKTA QSFSLQEIQT PIIKRQLQAL QQSGSSALSA DKNKQLNTIL 
       130        140        150        160        170        180 
NTMSTIYSTG KVCNPKNPQE CLLLEPGLDE IMATSTDYNS RLWAWEGWRA EVGKQLRPLY 
       190        200        210        220        230        240 
EEYVVLKNEM ARANNYNDYG DYWRGDYEAE GADGYNYNRN QLIEDVERTF AEIKPLYEHL 
       250        260        270        280        290        300 
HAYVRRKLMD TYPSYISPTG CLPAHLLGDM WGRFWTNLYP LTVPFAQKPN IDVTDAMMNQ 
       310        320        330        340        350        360 
GWDAERIFQE AEKFFVSVGL PHMTQGFWAN SMLTEPADGR KVVCHPTAWD LGHGDFRIKM 
       370        380        390        400        410        420 
CTKVTMDNFL TAHHEMGHIQ YDMAYARQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS 
       430        440        450        460        470        480 
IGLLPSDFQE DSETEINFLL KQALTIVGTL PFTYMLEKWR WMVFRGEIPK EQWMKKWWEM 
       490        500        510        520        530        540 
KREIVGVVEP LPHDETYCDP ASLFHVSNDY SFIRYYTRTI YQFQFQEALC QAAKYNGSLH 
       550        560        570        580        590        600 
KCDISNSTEA GQKLLKMLSL GNSEPWTKAL ENVVGARNMD VKPLLNYFQP LFDWLKEQNR 
       610        620        630        640        650        660 
NSFVGWNTEW SPYADQSIKV RISLKSALGA NAYEWTNNEM FLFRSSVAYA MRKYFSIIKN 
       670        680        690        700        710        720 
QTVPFLEEDV RVSDLKPRVS FYFFVTSPQN VSDVIPRSEV EDAIRMSRGR INDVFGLNDN 
       730        740        750        760        770        780 
SLEFLGIHPT LEPPYQPPVT IWLIIFGVVM ALVVVGIIIL IVTGIKGRKK KNETKREENP 
       790        800    
YDSMDIGKGE SNAGFQNSDD AQTSF



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Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 0 Cleavages - 3 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8R0I0-1-unknown MSSSSW... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt66132
    Q8R0I0-18-unknown QSLTEE... 18 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8R0I0-18-unknown QSLTEE... 18 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt112028

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates