TopFIND 4.0

O08759: Ubiquitin-protein ligase E3A

General Information

Protein names
- Ubiquitin-protein ligase E3A
- 2.3.2.26 {ECO:0000269|PubMed:20211139}
- HECT-type ubiquitin transferase E3A
- Oncogenic protein-associated protein E6-AP
Gene names Ube3a
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID O08759

2

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MATACKRSPG ESQSEDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFLR 
        70         80         90        100        110        120 
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG ASNNSEIKMN KKEGKDFKDV 
       130        140        150        160        170        180 
IYLTEEKVYE IYEFCRESED YSPLIRVIGR IFSSAEALVL SFRKVKQHTK EELKSLQEKD 
       190        200        210        220        230        240 
EDKDEDEKEK AACSAAAMEE DSEASSSRMG DSSQGDNNVQ KLGPDDVTVD IDAIRRVYSS 
       250        260        270        280        290        300 
LLANEKLETA FLNALVYLSP NVECDLTYHN VYTRDPNYLN LFIIVMENSN LHSPEYLEMA 
       310        320        330        340        350        360 
LPLFCKAMCK LPLEAQGKLI RLWSKYSADQ IRRMMETFQQ LITYKVISNE FNSRNLVNDD 
       370        380        390        400        410        420 
DAIVAASKCL KMVYYANVVG GDVDTNHNEE DDEEPIPESS ELTLQELLGD ERRNKKGPRV 
       430        440        450        460        470        480 
DPLETELGVK TLDCRKPLIS FEEFINEPLN DVLEMDKDYT FFKVETENKF SFMTCPFILN 
       490        500        510        520        530        540 
AVTKNLGLYY DNRIRMYSER RITVLYSLVQ GQQLNPYLRL KVRRDHIIDD ALVRLEMIAM 
       550        560        570        580        590        600 
ENPADLKKQL YVEFEGEQGV DEGGVSKEFF QLVVEEIFNP DIGMFTYDEA TKLFWFNPSS 
       610        620        630        640        650        660 
FETEGQFTLI GIVLGLAIYN NCILDVHFPM VVYRKLMGKK GTFRDLGDSH PVLYQSLKDL 
       670        680        690        700        710        720 
LEYEGSVEDD MMITFQISQT DLFGNPMMYD LKENGDKIPI TNENRKEFVN LYSDYILNKS 
       730        740        750        760        770        780 
VEKQFKAFRR GFHMVTNESP LKYLFRPEEI ELLICGSRNL DFQALEETTE YDGGYTRESV 
       790        800        810        820        830        840 
VIREFWEIVH SFTDEQKRLF LQFTTGTDRA PVGGLGKLKM IIAKNGPDTE RLPTSHTCFN 
       850        860        870    
VLLLPEYSSK EKLKERLLKA ITYAKGFGML 

Isoforms

- Isoform 2 of Ubiquitin-protein ligase E3A - Isoform 3 of Ubiquitin-protein ligase E3A

Sequence View

        10         20         30         40         50         60 
MATACKRSPG ESQSEDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFLR 
        70         80         90        100        110        120 
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG ASNNSEIKMN KKEGKDFKDV 
       130        140        150        160        170        180 
IYLTEEKVYE IYEFCRESED YSPLIRVIGR IFSSAEALVL SFRKVKQHTK EELKSLQEKD 
       190        200        210        220        230        240 
EDKDEDEKEK AACSAAAMEE DSEASSSRMG DSSQGDNNVQ KLGPDDVTVD IDAIRRVYSS 
       250        260        270        280        290        300 
LLANEKLETA FLNALVYLSP NVECDLTYHN VYTRDPNYLN LFIIVMENSN LHSPEYLEMA 
       310        320        330        340        350        360 
LPLFCKAMCK LPLEAQGKLI RLWSKYSADQ IRRMMETFQQ LITYKVISNE FNSRNLVNDD 
       370        380        390        400        410        420 
DAIVAASKCL KMVYYANVVG GDVDTNHNEE DDEEPIPESS ELTLQELLGD ERRNKKGPRV 
       430        440        450        460        470        480 
DPLETELGVK TLDCRKPLIS FEEFINEPLN DVLEMDKDYT FFKVETENKF SFMTCPFILN 
       490        500        510        520        530        540 
AVTKNLGLYY DNRIRMYSER RITVLYSLVQ GQQLNPYLRL KVRRDHIIDD ALVRLEMIAM 
       550        560        570        580        590        600 
ENPADLKKQL YVEFEGEQGV DEGGVSKEFF QLVVEEIFNP DIGMFTYDEA TKLFWFNPSS 
       610        620        630        640        650        660 
FETEGQFTLI GIVLGLAIYN NCILDVHFPM VVYRKLMGKK GTFRDLGDSH PVLYQSLKDL 
       670        680        690        700        710        720 
LEYEGSVEDD MMITFQISQT DLFGNPMMYD LKENGDKIPI TNENRKEFVN LYSDYILNKS 
       730        740        750        760        770        780 
VEKQFKAFRR GFHMVTNESP LKYLFRPEEI ELLICGSRNL DFQALEETTE YDGGYTRESV 
       790        800        810        820        830        840 
VIREFWEIVH SFTDEQKRLF LQFTTGTDRA PVGGLGKLKM IIAKNGPDTE RLPTSHTCFN 
       850        860        870    
VLLLPEYSSK EKLKERLLKA ITYAKGFGML          10         20         30         40         50         60 
MATACKRSPG ESQSEDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFLR 
        70         80         90        100        110        120 
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG ASNNSEIKMN KKEGKDFKDV 
       130        140        150        160        170        180 
IYLTEEKVYE IYEFCRESED YSPLIRVIGR IFSSAEALVL SFRKVKQHTK EELKSLQEKD 
       190        200        210        220        230        240 
EDKDEDEKEK AACSAAAMEE DSEASSSRMG DSSQGDNNVQ KLGPDDVTVD IDAIRRVYSS 
       250        260        270        280        290        300 
LLANEKLETA FLNALVYLSP NVECDLTYHN VYTRDPNYLN LFIIVMENSN LHSPEYLEMA 
       310        320        330        340        350        360 
LPLFCKAMCK LPLEAQGKLI RLWSKYSADQ IRRMMETFQQ LITYKVISNE FNSRNLVNDD 
       370        380        390        400        410        420 
DAIVAASKCL KMVYYANVVG GDVDTNHNEE DDEEPIPESS ELTLQELLGD ERRNKKGPRV 
       430        440        450        460        470        480 
DPLETELGVK TLDCRKPLIS FEEFINEPLN DVLEMDKDYT FFKVETENKF SFMTCPFILN 
       490        500        510        520        530        540 
AVTKNLGLYY DNRIRMYSER RITVLYSLVQ GQQLNPYLRL KVRRDHIIDD ALVRLEMIAM 
       550        560        570        580        590        600 
ENPADLKKQL YVEFEGEQGV DEGGVSKEFF QLVVEEIFNP DIGMFTYDEA TKLFWFNPSS 
       610        620        630        640        650        660 
FETEGQFTLI GIVLGLAIYN NCILDVHFPM VVYRKLMGKK GTFRDLGDSH PVLYQSLKDL 
       670        680        690        700        710        720 
LEYEGSVEDD MMITFQISQT DLFGNPMMYD LKENGDKIPI TNENRKEFVN LYSDYILNKS 
       730        740        750        760        770        780 
VEKQFKAFRR GFHMVTNESP LKYLFRPEEI ELLICGSRNL DFQALEETTE YDGGYTRESV 
       790        800        810        820        830        840 
VIREFWEIVH SFTDEQKRLF LQFTTGTDRA PVGGLGKLKM IIAKNGPDTE RLPTSHTCFN 
       850        860        870    
VLLLPEYSSK EKLKERLLKA ITYAKGFGML 



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(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O08759-1-unknown MATACK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O08759-415-unknown KKGPRV... 415 inferred from cleavage unknown TopFIND Inferred from cleavage TC32280

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)