O14641: Segment polarity protein dishevelled homolog DVL-2

General Information

Protein names	- Segment polarity protein dishevelled homolog DVL-2 - Dishevelled-2 - DSH homolog 2
Gene names	DVL2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14641

2 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM
        70         80         90        100        110        120
DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPVHEPRAEL APPAPPLPPL
       130        140        150        160        170        180
PPERTSGIGD SRPPSFHPNV SSSHENLEPE TETESVVSLR RERPRRRDSS EHGAGGHRTG
       190        200        210        220        230        240
GPSRLERHLA GYESSSTLMT SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR
       250        260        270        280        290        300
KQRPPRLERT SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM
       310        320        330        340        350        360
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT VAKCWDPSPQ
       370        380        390        400        410        420
AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS TITSGSSLPD GCEGRGLSVH
       430        440        450        460        470        480
TDMASVTKAM AAPESGLEVR DRMWLKITIP NAFLGSDVVD WLYHHVEGFP ERREARKYAS
       490        500        510        520        530        540
GLLKAGLIRH TVNKITFSEQ CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP
       550        560        570        580        590        600
GATPWPLLPT FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG
       610        620        630        640        650        660
AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG STGGAPNLRA
       670        680        690        700        710        720
HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG APPVRDLGSV PPELTASRQS
       730
FHMAMGNPSE FFVDVM

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14641-1-unknown	MAGSST...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14641-423-unknown	MASVTK...	423		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10678

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KCWDPS	357	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458209
...FTLPRN	367	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000459991
...SVHTDM	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10678
...DGGPPP	646	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458465
...FVDVM	736	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	422	HTDM.\|.MASV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)