O14874: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

General Information

Protein names	- 3-methyl-2-oxobutanoate dehydrogenase lipoamide]] kinase, mitochondrial - 2.7.11.4 - Branched-chain alpha-ketoacid dehydrogenase kinase - BCKD-kinase - BCKDHKIN
Gene names	BCKDK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14874

3 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial - Isoform 3 of [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Sequence View

        10         20         30         40         50         60
MILASVLRSG PGGGLPLRPL LGPALALRAR STSATDTHHV EMARERSKTV TSFYNQSAID
        70         80         90        100        110        120
AAAEKPSVRL TPTMMLYAGR SQDGSHLLKS ARYLQQELPV RIAHRIKGFR CLPFIIGCNP
       130        140        150        160        170        180
TILHVHELYI RAFQKLTDFP PIKDQADEAQ YCQLVRQLLD DHKDVVTLLA EGLRESRKHI
       190        200        210        220        230        240
EDEKLVRYFL DKTLTSRLGI RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR
       250        260        270        280        290        300
LCEHKYGNAP RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI
       310        320        330        340        350        360
TIANNDVDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRISPLFG HLDMHSGAQS
       370        380        390        400        410
GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL RHIDGREESF RI         10         20         30         40         50         60
MILASVLRSG PGGGLPLRPL LGPALALRAR STSATDTHHV EMARERSKTV TSFYNQSAID
        70         80         90        100        110        120
AAAEKPSVRL TPTMMLYAGR SQDGSHLLKS ARYLQQELPV RIAHRIKGFR CLPFIIGCNP
       130        140        150        160        170        180
TILHVHELYI RAFQKLTDFP PIKDQADEAQ YCQLVRQLLD DHKDVVTLLA EGLRESRKHI
       190        200        210        220        230        240
EDEKLVRYFL DKTLTSRLGI RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR
       250        260        270        280        290        300
LCEHKYGNAP RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI
       310        320        330        340        350        360
TIANNDVDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRISPLFG HLDMHSGAQS
       370        380        390        400        410
GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL RHIDGREESF RI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14874-1-unknown	MILASV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68320
O14874-1-unknown	MILASV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68321
O14874-31-	STSATD...	31		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O14874-31-	STSATD...	31		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O14874-31-	STSATD...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O14874-31-	STSATD...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O14874-31-	STSATD...	31		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O14874-31-	STSATD...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14874-31-	STSATD...	31		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O14874-31-	STSATD...	31		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O14874-31-unknown	STSATD...	31	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14874-31-unknown	STSATD...	31		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O14874-31-unknown	STSATD...	31	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt114879
O14874-31-unknown	STSATD...	31	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt114880
O14874-31-unknown	STSATD...	31	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QSAIDA	60	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455866
...QSAIDA	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113334
...QSAIDA	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113335
...GSHLLK	88	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000454947
...GSHLLK	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113337
...GSHLLK	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113338
...ICTRLS	225	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457226
...ICTRLS	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113340
...ICTRLS	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113341
...GPMHGF	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63938
...GPMHGF	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63939
...GPMHGF	365	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000378404
...GPMHGF	365	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000287507
...ESFRI	412	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)