O14976: Cyclin-G-associated kinase

General Information

Protein names	- Cyclin-G-associated kinase - 2.7.11.1
Gene names	GAK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14976

10 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDV
        70         80         90        100        110        120
GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL
       130        140        150        160        170        180
LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL
       190        200        210        220        230        240
LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI
       250        260        270        280        290        300
GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP
       310        320        330        340        350        360
EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP VGPAGSGYSG
       370        380        390        400        410        420
GLALAEYDQP YGGFLDILRG GTERLFTNLK DTSSKVIQSV ANYAKGDLDI SYITSRIAVM
       430        440        450        460        470        480
SFPAEGVESA LKNNIEDVRL FLDSKHPGHY AVYNLSPRTY RPSRFHNRVS ECGWAARRAP
       490        500        510        520        530        540
HLHTLYNICR NMHAWLRQDH KNVCVVHCMD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS
       550        560        570        580        590        600
MKRCPPGIWP SHKRYIEYMC DMVAEEPITP HSKPILVRAV VMTPVPLFSK QRSGCRPFCE
       610        620        630        640        650        660
VYVGDERVAS TSQEYDKMRD FKIEDGKAVI PLGVTVQGDV LIVIYHARST LGGRLQAKMA
       670        680        690        700        710        720
SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL FQVNLEVEVE PRDRPSREAP
       730        740        750        760        770        780
PWENSSMRGL NPKILFSSRE EQQDILSKFG KPELPRQPGS TAQYDAGAGS PEAEPTDSDS
       790        800        810        820        830        840
PPSSSADASR FLHTLDWQEE KEAETGAENA SSKESESALM EDRDESEVSD EGGSPISSEG
       850        860        870        880        890        900
QEPRADPEPP GLAAGLVQQD LVFEVETPAV LPEPVPQEDG VDLLGLHSEV GAGPAVPPQA
       910        920        930        940        950        960
CKAPSSNTDL LSCLLGPPEA ASQGPPEDLL SEDPLLLASP APPLSVQSTP RGGPPAAADP
       970        980        990       1000       1010       1020
FGPLLPSSGN NSQPCSNPDL FGEFLNSDSV TVPPSFPSAH SAPPPSCSAD FLHLGDLPGE
      1030       1040       1050       1060       1070       1080
PSKMTASSSN PDLLGGWAAW TETAASAVAP TPATEGPLFS PGGQPAPCGS QASWTKSQNP
      1090       1100       1110       1120       1130       1140
DPFADLGDLS SGLQGSPAGF PPGGFIPKTA TTPKGSSSWQ TSRPPAQGAS WPPQAKPPPK
      1150       1160       1170       1180       1190       1200
ACTQPRPNYA SNFSVIGARE ERGVRAPSFA QKPKVSENDF EDLLSNQGFS SRSDKKGPKT
      1210       1220       1230       1240       1250       1260
IAEMRKQDLA KDTDPLKLKL LDWIEGKERN IRALLSTLHT VLWDGESRWT PVGMADLVAP
      1270       1280       1290       1300       1310
EQVKKHYRRA VLAVHPDKAA GQPYEQHAKM IFMELNDAWS EFENQGSRPL F

Isoforms

- Isoform 2 of Cyclin-G-associated kinase

Sequence View

        10         20         30         40         50         60
MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDV
        70         80         90        100        110        120
GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL
       130        140        150        160        170        180
LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL
       190        200        210        220        230        240
LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI
       250        260        270        280        290        300
GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP
       310        320        330        340        350        360
EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP VGPAGSGYSG
       370        380        390        400        410        420
GLALAEYDQP YGGFLDILRG GTERLFTNLK DTSSKVIQSV ANYAKGDLDI SYITSRIAVM
       430        440        450        460        470        480
SFPAEGVESA LKNNIEDVRL FLDSKHPGHY AVYNLSPRTY RPSRFHNRVS ECGWAARRAP
       490        500        510        520        530        540
HLHTLYNICR NMHAWLRQDH KNVCVVHCMD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS
       550        560        570        580        590        600
MKRCPPGIWP SHKRYIEYMC DMVAEEPITP HSKPILVRAV VMTPVPLFSK QRSGCRPFCE
       610        620        630        640        650        660
VYVGDERVAS TSQEYDKMRD FKIEDGKAVI PLGVTVQGDV LIVIYHARST LGGRLQAKMA
       670        680        690        700        710        720
SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL FQVNLEVEVE PRDRPSREAP
       730        740        750        760        770        780
PWENSSMRGL NPKILFSSRE EQQDILSKFG KPELPRQPGS TAQYDAGAGS PEAEPTDSDS
       790        800        810        820        830        840
PPSSSADASR FLHTLDWQEE KEAETGAENA SSKESESALM EDRDESEVSD EGGSPISSEG
       850        860        870        880        890        900
QEPRADPEPP GLAAGLVQQD LVFEVETPAV LPEPVPQEDG VDLLGLHSEV GAGPAVPPQA
       910        920        930        940        950        960
CKAPSSNTDL LSCLLGPPEA ASQGPPEDLL SEDPLLLASP APPLSVQSTP RGGPPAAADP
       970        980        990       1000       1010       1020
FGPLLPSSGN NSQPCSNPDL FGEFLNSDSV TVPPSFPSAH SAPPPSCSAD FLHLGDLPGE
      1030       1040       1050       1060       1070       1080
PSKMTASSSN PDLLGGWAAW TETAASAVAP TPATEGPLFS PGGQPAPCGS QASWTKSQNP
      1090       1100       1110       1120       1130       1140
DPFADLGDLS SGLQGSPAGF PPGGFIPKTA TTPKGSSSWQ TSRPPAQGAS WPPQAKPPPK
      1150       1160       1170       1180       1190       1200
ACTQPRPNYA SNFSVIGARE ERGVRAPSFA QKPKVSENDF EDLLSNQGFS SRSDKKGPKT
      1210       1220       1230       1240       1250       1260
IAEMRKQDLA KDTDPLKLKL LDWIEGKERN IRALLSTLHT VLWDGESRWT PVGMADLVAP
      1270       1280       1290       1300       1310
EQVKKHYRRA VLAVHPDKAA GQPYEQHAKM IFMELNDAWS EFENQGSRPL F

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14976-1-unknown	MSLLQS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75672
O14976-2-unknown	MSLLQS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14976-2-Acetylation	SLLQSA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14976-2-Acetylation	SLLQSA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110754
O14976-89-unknown	MKKLSG...	89		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000422391
O14976-769-	GSPEAE...	769			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O14976-769-unknown	GSPEAE...	769			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O14976-769-unknown	GSPEAE...	769		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161586
O14976-1008-	SADFLH...	1008			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14976-1008-unknown	SADFLH...	1008		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174128
O14976-1170-unknown	AQKPKV...	1170		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168106
O14976-1170-	AQKPKV...	1170			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QTCRAV	158	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000422391
...QTCRAV	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112893
...IGEKQD	244	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424701
...IGEKQD	244	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112891
...WPPQAK	1135	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426062
...WPPQAK	1135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112889
...SRPLF	1311	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SRPLF	1311	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71290

TopFIND

O14976: Cyclin-G-associated kinase

General Information

10

N-termini

4

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Protein Neighborhood

Domains & Features

10 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates