O15027: Protein transport protein Sec16A

General Information

Protein names	- Protein transport protein Sec16A - SEC16 homolog A - p250 {ECO:0000303\|PubMed:17428803}
Gene names	SEC16A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15027

23 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein transport protein Sec16A - Isoform 3 of Protein transport protein Sec16A - Isoform 4 of Protein transport protein Sec16A - Isoform 5 of Protein transport protein Sec16A - Isoform 2 of Protein transport protein Sec16A - Isoform 3 of Protein transport protein Sec16A - Isoform 4 of Protein transport protein Sec16A - Isoform 5 of Protein transport protein Sec16A

Sequence View

        10         20         30         40         50         60
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP VTDPFAFSRQ
        70         80         90        100        110        120
ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR DSSQGPCEPL PGPLTQPRAH
       130        140        150        160        170        180
ASPFSGALTP SAPPGPEMNR SAEVGPSSEP EVQTLPYLPH YIPGVDPETS HGGHPHGNMP
       190        200        210        220        230        240
GLDRPLSRQN PHDGVVTPAA SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG
       250        260        270        280        290        300
VPCATSVPHF PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
       310        320        330        340        350        360
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP LGAGAGSGCA
       370        380        390        400        410        420
PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF DDFCSSPGLG RPPAPTHVGA
       430        440        450        460        470        480
GSLCQALLPG PSNEAAGDVW GDTASTGVPD ASGSQYENVE NLEFVQNQEV LPSEPLNLDP
       490        500        510        520        530        540
SSPSDQFRYG PLPGPAVPRH GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ
       550        560        570        580        590        600
ELVGTFIQQE VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
       610        620        630        640        650        660
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA LPDASPGNLE
       670        680        690        700        710        720
QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV YPAPEKRPSA RTQGPVKCES
       730        740        750        760        770        780
PATTLWAQSE LPDFGGNVLL APAAPALYVC AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ
       790        800        810        820        830        840
SRGGIGASEN LENPPKMGEE EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA
       850        860        870        880        890        900
QPINFSVSLS NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
       910        920        930        940        950        960
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA LPGFANSPAG
       970        980        990       1000       1010       1020
STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR TLENPVNVYN PSHSDSLASQ
      1030       1040       1050       1060       1070       1080
QSVASHPRQS GPGAPNLDRF YQQVTKDAQG QPGLERAQQE LVPPQQQASP PQLPKAMFSE
      1090       1100       1110       1120       1130       1140
LSNPESLPAQ GQAQNSAQSP ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW
      1150       1160       1170       1180       1190       1200
PQPVPALAPG PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
      1210       1220       1230       1240       1250       1260
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS SQSDYYASYY
      1270       1280       1290       1300       1310       1320
SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY RREHSAFGDR PEKRDNNWRY
      1330       1340       1350       1360       1370       1380
DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS EHSARSLHSA HSLASRRSSL SSHSHQSQIY
      1390       1400       1410       1420       1430       1440
RSHNVAAGSY EAPLPPGSFH GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT
      1450       1460       1470       1480       1490       1500
SPEKFSVPHV CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
      1510       1520       1530       1540       1550       1560
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT VVGTDIAELL
      1570       1580       1590       1600       1610       1620
LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL SFLTGGPAAA ASSLERETER
      1630       1640       1650       1660       1670       1680
FRELLLYGRK KDALESAMKN GLWGHALLLA SKMDSRTHAR VMTRFANSLP INDPLQTVYQ
      1690       1700       1710       1720       1730       1740
LMSGRMPAAS TCCGDEKWGD WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH
      1750       1760       1770       1780       1790       1800
FCYLMAQAGF GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
      1810       1820       1830       1840       1850       1860
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ MASQLRLFDP
      1870       1880       1890       1900       1910       1920
QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL PQQCPGTPSS EMEQLDRPGL
      1930       1940       1950       1960       1970       1980
SQPGALGIAN PLLAVPAPSP EHSSPSVRLL PSAPQTLPDG PLASPARVPM FPVPLPPGPL
      1990       2000       2010       2020       2030       2040
EPGPGCVTPG PALGFLEPSG PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE
      2050       2060       2070       2080       2090       2100
LSEENFDGKF ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
      2110       2120       2130       2140       2150       2160
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK KAPPPPPTSM
      2170       2180       2190       2200       2210       2220
PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS GTQRSEPALA PADFVAPLAP
      2230       2240       2250       2260       2270       2280
LPIPSNLFVP TPDAEEPQLP DGTGREGPAA ARGLANPEPA PEPKVLSSAA SLPGSELPSS
      2290       2300       2310       2320       2330       2340
RPEGSQGGEL SRCSSMSSLS REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS
      2350
GSSRLGRIGQ RKHLVLN         10         20         30         40         50         60
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP VTDPFAFSRQ
        70         80         90        100        110        120
ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR DSSQGPCEPL PGPLTQPRAH
       130        140        150        160        170        180
ASPFSGALTP SAPPGPEMNR SAEVGPSSEP EVQTLPYLPH YIPGVDPETS HGGHPHGNMP
       190        200        210        220        230        240
GLDRPLSRQN PHDGVVTPAA SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG
       250        260        270        280        290        300
VPCATSVPHF PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
       310        320        330        340        350        360
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP LGAGAGSGCA
       370        380        390        400        410        420
PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF DDFCSSPGLG RPPAPTHVGA
       430        440        450        460        470        480
GSLCQALLPG PSNEAAGDVW GDTASTGVPD ASGSQYENVE NLEFVQNQEV LPSEPLNLDP
       490        500        510        520        530        540
SSPSDQFRYG PLPGPAVPRH GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ
       550        560        570        580        590        600
ELVGTFIQQE VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
       610        620        630        640        650        660
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA LPDASPGNLE
       670        680        690        700        710        720
QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV YPAPEKRPSA RTQGPVKCES
       730        740        750        760        770        780
PATTLWAQSE LPDFGGNVLL APAAPALYVC AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ
       790        800        810        820        830        840
SRGGIGASEN LENPPKMGEE EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA
       850        860        870        880        890        900
QPINFSVSLS NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
       910        920        930        940        950        960
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA LPGFANSPAG
       970        980        990       1000       1010       1020
STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR TLENPVNVYN PSHSDSLASQ
      1030       1040       1050       1060       1070       1080
QSVASHPRQS GPGAPNLDRF YQQVTKDAQG QPGLERAQQE LVPPQQQASP PQLPKAMFSE
      1090       1100       1110       1120       1130       1140
LSNPESLPAQ GQAQNSAQSP ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW
      1150       1160       1170       1180       1190       1200
PQPVPALAPG PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
      1210       1220       1230       1240       1250       1260
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS SQSDYYASYY
      1270       1280       1290       1300       1310       1320
SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY RREHSAFGDR PEKRDNNWRY
      1330       1340       1350       1360       1370       1380
DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS EHSARSLHSA HSLASRRSSL SSHSHQSQIY
      1390       1400       1410       1420       1430       1440
RSHNVAAGSY EAPLPPGSFH GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT
      1450       1460       1470       1480       1490       1500
SPEKFSVPHV CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
      1510       1520       1530       1540       1550       1560
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT VVGTDIAELL
      1570       1580       1590       1600       1610       1620
LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL SFLTGGPAAA ASSLERETER
      1630       1640       1650       1660       1670       1680
FRELLLYGRK KDALESAMKN GLWGHALLLA SKMDSRTHAR VMTRFANSLP INDPLQTVYQ
      1690       1700       1710       1720       1730       1740
LMSGRMPAAS TCCGDEKWGD WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH
      1750       1760       1770       1780       1790       1800
FCYLMAQAGF GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
      1810       1820       1830       1840       1850       1860
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ MASQLRLFDP
      1870       1880       1890       1900       1910       1920
QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL PQQCPGTPSS EMEQLDRPGL
      1930       1940       1950       1960       1970       1980
SQPGALGIAN PLLAVPAPSP EHSSPSVRLL PSAPQTLPDG PLASPARVPM FPVPLPPGPL
      1990       2000       2010       2020       2030       2040
EPGPGCVTPG PALGFLEPSG PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE
      2050       2060       2070       2080       2090       2100
LSEENFDGKF ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
      2110       2120       2130       2140       2150       2160
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK KAPPPPPTSM
      2170       2180       2190       2200       2210       2220
PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS GTQRSEPALA PADFVAPLAP
      2230       2240       2250       2260       2270       2280
LPIPSNLFVP TPDAEEPQLP DGTGREGPAA ARGLANPEPA PEPKVLSSAA SLPGSELPSS
      2290       2300       2310       2320       2330       2340
RPEGSQGGEL SRCSSMSSLS REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS
      2350
GSSRLGRIGQ RKHLVLN         10         20         30         40         50         60
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP VTDPFAFSRQ
        70         80         90        100        110        120
ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR DSSQGPCEPL PGPLTQPRAH
       130        140        150        160        170        180
ASPFSGALTP SAPPGPEMNR SAEVGPSSEP EVQTLPYLPH YIPGVDPETS HGGHPHGNMP
       190        200        210        220        230        240
GLDRPLSRQN PHDGVVTPAA SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG
       250        260        270        280        290        300
VPCATSVPHF PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
       310        320        330        340        350        360
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP LGAGAGSGCA
       370        380        390        400        410        420
PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF DDFCSSPGLG RPPAPTHVGA
       430        440        450        460        470        480
GSLCQALLPG PSNEAAGDVW GDTASTGVPD ASGSQYENVE NLEFVQNQEV LPSEPLNLDP
       490        500        510        520        530        540
SSPSDQFRYG PLPGPAVPRH GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ
       550        560        570        580        590        600
ELVGTFIQQE VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
       610        620        630        640        650        660
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA LPDASPGNLE
       670        680        690        700        710        720
QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV YPAPEKRPSA RTQGPVKCES
       730        740        750        760        770        780
PATTLWAQSE LPDFGGNVLL APAAPALYVC AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ
       790        800        810        820        830        840
SRGGIGASEN LENPPKMGEE EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA
       850        860        870        880        890        900
QPINFSVSLS NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
       910        920        930        940        950        960
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA LPGFANSPAG
       970        980        990       1000       1010       1020
STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR TLENPVNVYN PSHSDSLASQ
      1030       1040       1050       1060       1070       1080
QSVASHPRQS GPGAPNLDRF YQQVTKDAQG QPGLERAQQE LVPPQQQASP PQLPKAMFSE
      1090       1100       1110       1120       1130       1140
LSNPESLPAQ GQAQNSAQSP ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW
      1150       1160       1170       1180       1190       1200
PQPVPALAPG PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
      1210       1220       1230       1240       1250       1260
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS SQSDYYASYY
      1270       1280       1290       1300       1310       1320
SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY RREHSAFGDR PEKRDNNWRY
      1330       1340       1350       1360       1370       1380
DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS EHSARSLHSA HSLASRRSSL SSHSHQSQIY
      1390       1400       1410       1420       1430       1440
RSHNVAAGSY EAPLPPGSFH GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT
      1450       1460       1470       1480       1490       1500
SPEKFSVPHV CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
      1510       1520       1530       1540       1550       1560
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT VVGTDIAELL
      1570       1580       1590       1600       1610       1620
LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL SFLTGGPAAA ASSLERETER
      1630       1640       1650       1660       1670       1680
FRELLLYGRK KDALESAMKN GLWGHALLLA SKMDSRTHAR VMTRFANSLP INDPLQTVYQ
      1690       1700       1710       1720       1730       1740
LMSGRMPAAS TCCGDEKWGD WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH
      1750       1760       1770       1780       1790       1800
FCYLMAQAGF GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
      1810       1820       1830       1840       1850       1860
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ MASQLRLFDP
      1870       1880       1890       1900       1910       1920
QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL PQQCPGTPSS EMEQLDRPGL
      1930       1940       1950       1960       1970       1980
SQPGALGIAN PLLAVPAPSP EHSSPSVRLL PSAPQTLPDG PLASPARVPM FPVPLPPGPL
      1990       2000       2010       2020       2030       2040
EPGPGCVTPG PALGFLEPSG PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE
      2050       2060       2070       2080       2090       2100
LSEENFDGKF ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
      2110       2120       2130       2140       2150       2160
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK KAPPPPPTSM
      2170       2180       2190       2200       2210       2220
PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS GTQRSEPALA PADFVAPLAP
      2230       2240       2250       2260       2270       2280
LPIPSNLFVP TPDAEEPQLP DGTGREGPAA ARGLANPEPA PEPKVLSSAA SLPGSELPSS
      2290       2300       2310       2320       2330       2340
RPEGSQGGEL SRCSSMSSLS REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS
      2350
GSSRLGRIGQ RKHLVLN         10         20         30         40         50         60
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP VTDPFAFSRQ
        70         80         90        100        110        120
ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR DSSQGPCEPL PGPLTQPRAH
       130        140        150        160        170        180
ASPFSGALTP SAPPGPEMNR SAEVGPSSEP EVQTLPYLPH YIPGVDPETS HGGHPHGNMP
       190        200        210        220        230        240
GLDRPLSRQN PHDGVVTPAA SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG
       250        260        270        280        290        300
VPCATSVPHF PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
       310        320        330        340        350        360
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP LGAGAGSGCA
       370        380        390        400        410        420
PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF DDFCSSPGLG RPPAPTHVGA
       430        440        450        460        470        480
GSLCQALLPG PSNEAAGDVW GDTASTGVPD ASGSQYENVE NLEFVQNQEV LPSEPLNLDP
       490        500        510        520        530        540
SSPSDQFRYG PLPGPAVPRH GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ
       550        560        570        580        590        600
ELVGTFIQQE VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
       610        620        630        640        650        660
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA LPDASPGNLE
       670        680        690        700        710        720
QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV YPAPEKRPSA RTQGPVKCES
       730        740        750        760        770        780
PATTLWAQSE LPDFGGNVLL APAAPALYVC AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ
       790        800        810        820        830        840
SRGGIGASEN LENPPKMGEE EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA
       850        860        870        880        890        900
QPINFSVSLS NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
       910        920        930        940        950        960
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA LPGFANSPAG
       970        980        990       1000       1010       1020
STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR TLENPVNVYN PSHSDSLASQ
      1030       1040       1050       1060       1070       1080
QSVASHPRQS GPGAPNLDRF YQQVTKDAQG QPGLERAQQE LVPPQQQASP PQLPKAMFSE
      1090       1100       1110       1120       1130       1140
LSNPESLPAQ GQAQNSAQSP ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW
      1150       1160       1170       1180       1190       1200
PQPVPALAPG PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
      1210       1220       1230       1240       1250       1260
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS SQSDYYASYY
      1270       1280       1290       1300       1310       1320
SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY RREHSAFGDR PEKRDNNWRY
      1330       1340       1350       1360       1370       1380
DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS EHSARSLHSA HSLASRRSSL SSHSHQSQIY
      1390       1400       1410       1420       1430       1440
RSHNVAAGSY EAPLPPGSFH GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT
      1450       1460       1470       1480       1490       1500
SPEKFSVPHV CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
      1510       1520       1530       1540       1550       1560
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT VVGTDIAELL
      1570       1580       1590       1600       1610       1620
LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL SFLTGGPAAA ASSLERETER
      1630       1640       1650       1660       1670       1680
FRELLLYGRK KDALESAMKN GLWGHALLLA SKMDSRTHAR VMTRFANSLP INDPLQTVYQ
      1690       1700       1710       1720       1730       1740
LMSGRMPAAS TCCGDEKWGD WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH
      1750       1760       1770       1780       1790       1800
FCYLMAQAGF GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
      1810       1820       1830       1840       1850       1860
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ MASQLRLFDP
      1870       1880       1890       1900       1910       1920
QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL PQQCPGTPSS EMEQLDRPGL
      1930       1940       1950       1960       1970       1980
SQPGALGIAN PLLAVPAPSP EHSSPSVRLL PSAPQTLPDG PLASPARVPM FPVPLPPGPL
      1990       2000       2010       2020       2030       2040
EPGPGCVTPG PALGFLEPSG PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE
      2050       2060       2070       2080       2090       2100
LSEENFDGKF ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
      2110       2120       2130       2140       2150       2160
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK KAPPPPPTSM
      2170       2180       2190       2200       2210       2220
PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS GTQRSEPALA PADFVAPLAP
      2230       2240       2250       2260       2270       2280
LPIPSNLFVP TPDAEEPQLP DGTGREGPAA ARGLANPEPA PEPKVLSSAA SLPGSELPSS
      2290       2300       2310       2320       2330       2340
RPEGSQGGEL SRCSSMSSLS REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS
      2350
GSSRLGRIGQ RKHLVLN         10         20         30         40         50         60
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP VTDPFAFSRQ
        70         80         90        100        110        120
ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR DSSQGPCEPL PGPLTQPRAH
       130        140        150        160        170        180
ASPFSGALTP SAPPGPEMNR SAEVGPSSEP EVQTLPYLPH YIPGVDPETS HGGHPHGNMP
       190        200        210        220        230        240
GLDRPLSRQN PHDGVVTPAA SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG
       250        260        270        280        290        300
VPCATSVPHF PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
       310        320        330        340        350        360
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP LGAGAGSGCA
       370        380        390        400        410        420
PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF DDFCSSPGLG RPPAPTHVGA
       430        440        450        460        470        480
GSLCQALLPG PSNEAAGDVW GDTASTGVPD ASGSQYENVE NLEFVQNQEV LPSEPLNLDP
       490        500        510        520        530        540
SSPSDQFRYG PLPGPAVPRH GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ
       550        560        570        580        590        600
ELVGTFIQQE VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
       610        620        630        640        650        660
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA LPDASPGNLE
       670        680        690        700        710        720
QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV YPAPEKRPSA RTQGPVKCES
       730        740        750        760        770        780
PATTLWAQSE LPDFGGNVLL APAAPALYVC AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ
       790        800        810        820        830        840
SRGGIGASEN LENPPKMGEE EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA
       850        860        870        880        890        900
QPINFSVSLS NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
       910        920        930        940        950        960
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA LPGFANSPAG
       970        980        990       1000       1010       1020
STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR TLENPVNVYN PSHSDSLASQ
      1030       1040       1050       1060       1070       1080
QSVASHPRQS GPGAPNLDRF YQQVTKDAQG QPGLERAQQE LVPPQQQASP PQLPKAMFSE
      1090       1100       1110       1120       1130       1140
LSNPESLPAQ GQAQNSAQSP ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW
      1150       1160       1170       1180       1190       1200
PQPVPALAPG PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
      1210       1220       1230       1240       1250       1260
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS SQSDYYASYY
      1270       1280       1290       1300       1310       1320
SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY RREHSAFGDR PEKRDNNWRY
      1330       1340       1350       1360       1370       1380
DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS EHSARSLHSA HSLASRRSSL SSHSHQSQIY
      1390       1400       1410       1420       1430       1440
RSHNVAAGSY EAPLPPGSFH GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT
      1450       1460       1470       1480       1490       1500
SPEKFSVPHV CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
      1510       1520       1530       1540       1550       1560
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT VVGTDIAELL
      1570       1580       1590       1600       1610       1620
LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL SFLTGGPAAA ASSLERETER
      1630       1640       1650       1660       1670       1680
FRELLLYGRK KDALESAMKN GLWGHALLLA SKMDSRTHAR VMTRFANSLP INDPLQTVYQ
      1690       1700       1710       1720       1730       1740
LMSGRMPAAS TCCGDEKWGD WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH
      1750       1760       1770       1780       1790       1800
FCYLMAQAGF GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
      1810       1820       1830       1840       1850       1860
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ MASQLRLFDP
      1870       1880       1890       1900       1910       1920
QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL PQQCPGTPSS EMEQLDRPGL
      1930       1940       1950       1960       1970       1980
SQPGALGIAN PLLAVPAPSP EHSSPSVRLL PSAPQTLPDG PLASPARVPM FPVPLPPGPL
      1990       2000       2010       2020       2030       2040
EPGPGCVTPG PALGFLEPSG PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE
      2050       2060       2070       2080       2090       2100
LSEENFDGKF ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
      2110       2120       2130       2140       2150       2160
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK KAPPPPPTSM
      2170       2180       2190       2200       2210       2220
PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS GTQRSEPALA PADFVAPLAP
      2230       2240       2250       2260       2270       2280
LPIPSNLFVP TPDAEEPQLP DGTGREGPAA ARGLANPEPA PEPKVLSSAA SLPGSELPSS
      2290       2300       2310       2320       2330       2340
RPEGSQGGEL SRCSSMSSLS REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS
      2350
GSSRLGRIGQ RKHLVLN         10         20         30         40         50         60
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP VTDPFAFSRQ
        70         80         90        100        110        120
ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR DSSQGPCEPL PGPLTQPRAH
       130        140        150        160        170        180
ASPFSGALTP SAPPGPEMNR SAEVGPSSEP EVQTLPYLPH YIPGVDPETS HGGHPHGNMP
       190        200        210        220        230        240
GLDRPLSRQN PHDGVVTPAA SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG
       250        260        270        280        290        300
VPCATSVPHF PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
       310        320        330        340        350        360
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP LGAGAGSGCA
       370        380        390        400        410        420
PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF DDFCSSPGLG RPPAPTHVGA
       430        440        450        460        470        480
GSLCQALLPG PSNEAAGDVW GDTASTGVPD ASGSQYENVE NLEFVQNQEV LPSEPLNLDP
       490        500        510        520        530        540
SSPSDQFRYG PLPGPAVPRH GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ
       550        560        570        580        590        600
ELVGTFIQQE VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
       610        620        630        640        650        660
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA LPDASPGNLE
       670        680        690        700        710        720
QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV YPAPEKRPSA RTQGPVKCES
       730        740        750        760        770        780
PATTLWAQSE LPDFGGNVLL APAAPALYVC AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ
       790        800        810        820        830        840
SRGGIGASEN LENPPKMGEE EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA
       850        860        870        880        890        900
QPINFSVSLS NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
       910        920        930        940        950        960
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA LPGFANSPAG
       970        980        990       1000       1010       1020
STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR TLENPVNVYN PSHSDSLASQ
      1030       1040       1050       1060       1070       1080
QSVASHPRQS GPGAPNLDRF YQQVTKDAQG QPGLERAQQE LVPPQQQASP PQLPKAMFSE
      1090       1100       1110       1120       1130       1140
LSNPESLPAQ GQAQNSAQSP ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW
      1150       1160       1170       1180       1190       1200
PQPVPALAPG PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
      1210       1220       1230       1240       1250       1260
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS SQSDYYASYY
      1270       1280       1290       1300       1310       1320
SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY RREHSAFGDR PEKRDNNWRY
      1330       1340       1350       1360       1370       1380
DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS EHSARSLHSA HSLASRRSSL SSHSHQSQIY
      1390       1400       1410       1420       1430       1440
RSHNVAAGSY EAPLPPGSFH GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT
      1450       1460       1470       1480       1490       1500
SPEKFSVPHV CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
      1510       1520       1530       1540       1550       1560
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT VVGTDIAELL
      1570       1580       1590       1600       1610       1620
LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL SFLTGGPAAA ASSLERETER
      1630       1640       1650       1660       1670       1680
FRELLLYGRK KDALESAMKN GLWGHALLLA SKMDSRTHAR VMTRFANSLP INDPLQTVYQ
      1690       1700       1710       1720       1730       1740
LMSGRMPAAS TCCGDEKWGD WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH
      1750       1760       1770       1780       1790       1800
FCYLMAQAGF GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
      1810       1820       1830       1840       1850       1860
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ MASQLRLFDP
      1870       1880       1890       1900       1910       1920
QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL PQQCPGTPSS EMEQLDRPGL
      1930       1940       1950       1960       1970       1980
SQPGALGIAN PLLAVPAPSP EHSSPSVRLL PSAPQTLPDG PLASPARVPM FPVPLPPGPL
      1990       2000       2010       2020       2030       2040
EPGPGCVTPG PALGFLEPSG PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE
      2050       2060       2070       2080       2090       2100
LSEENFDGKF ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
      2110       2120       2130       2140       2150       2160
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK KAPPPPPTSM
      2170       2180       2190       2200       2210       2220
PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS GTQRSEPALA PADFVAPLAP
      2230       2240       2250       2260       2270       2280
LPIPSNLFVP TPDAEEPQLP DGTGREGPAA ARGLANPEPA PEPKVLSSAA SLPGSELPSS
      2290       2300       2310       2320       2330       2340
RPEGSQGGEL SRCSSMSSLS REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS
      2350
GSSRLGRIGQ RKHLVLN         10         20         30         40         50         60
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP VTDPFAFSRQ
        70         80         90        100        110        120
ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR DSSQGPCEPL PGPLTQPRAH
       130        140        150        160        170        180
ASPFSGALTP SAPPGPEMNR SAEVGPSSEP EVQTLPYLPH YIPGVDPETS HGGHPHGNMP
       190        200        210        220        230        240
GLDRPLSRQN PHDGVVTPAA SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG
       250        260        270        280        290        300
VPCATSVPHF PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
       310        320        330        340        350        360
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP LGAGAGSGCA
       370        380        390        400        410        420
PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF DDFCSSPGLG RPPAPTHVGA
       430        440        450        460        470        480
GSLCQALLPG PSNEAAGDVW GDTASTGVPD ASGSQYENVE NLEFVQNQEV LPSEPLNLDP
       490        500        510        520        530        540
SSPSDQFRYG PLPGPAVPRH GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ
       550        560        570        580        590        600
ELVGTFIQQE VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
       610        620        630        640        650        660
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA LPDASPGNLE
       670        680        690        700        710        720
QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV YPAPEKRPSA RTQGPVKCES
       730        740        750        760        770        780
PATTLWAQSE LPDFGGNVLL APAAPALYVC AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ
       790        800        810        820        830        840
SRGGIGASEN LENPPKMGEE EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA
       850        860        870        880        890        900
QPINFSVSLS NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
       910        920        930        940        950        960
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA LPGFANSPAG
       970        980        990       1000       1010       1020
STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR TLENPVNVYN PSHSDSLASQ
      1030       1040       1050       1060       1070       1080
QSVASHPRQS GPGAPNLDRF YQQVTKDAQG QPGLERAQQE LVPPQQQASP PQLPKAMFSE
      1090       1100       1110       1120       1130       1140
LSNPESLPAQ GQAQNSAQSP ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW
      1150       1160       1170       1180       1190       1200
PQPVPALAPG PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
      1210       1220       1230       1240       1250       1260
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS SQSDYYASYY
      1270       1280       1290       1300       1310       1320
SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY RREHSAFGDR PEKRDNNWRY
      1330       1340       1350       1360       1370       1380
DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS EHSARSLHSA HSLASRRSSL SSHSHQSQIY
      1390       1400       1410       1420       1430       1440
RSHNVAAGSY EAPLPPGSFH GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT
      1450       1460       1470       1480       1490       1500
SPEKFSVPHV CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
      1510       1520       1530       1540       1550       1560
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT VVGTDIAELL
      1570       1580       1590       1600       1610       1620
LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL SFLTGGPAAA ASSLERETER
      1630       1640       1650       1660       1670       1680
FRELLLYGRK KDALESAMKN GLWGHALLLA SKMDSRTHAR VMTRFANSLP INDPLQTVYQ
      1690       1700       1710       1720       1730       1740
LMSGRMPAAS TCCGDEKWGD WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH
      1750       1760       1770       1780       1790       1800
FCYLMAQAGF GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
      1810       1820       1830       1840       1850       1860
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ MASQLRLFDP
      1870       1880       1890       1900       1910       1920
QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL PQQCPGTPSS EMEQLDRPGL
      1930       1940       1950       1960       1970       1980
SQPGALGIAN PLLAVPAPSP EHSSPSVRLL PSAPQTLPDG PLASPARVPM FPVPLPPGPL
      1990       2000       2010       2020       2030       2040
EPGPGCVTPG PALGFLEPSG PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE
      2050       2060       2070       2080       2090       2100
LSEENFDGKF ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
      2110       2120       2130       2140       2150       2160
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK KAPPPPPTSM
      2170       2180       2190       2200       2210       2220
PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS GTQRSEPALA PADFVAPLAP
      2230       2240       2250       2260       2270       2280
LPIPSNLFVP TPDAEEPQLP DGTGREGPAA ARGLANPEPA PEPKVLSSAA SLPGSELPSS
      2290       2300       2310       2320       2330       2340
RPEGSQGGEL SRCSSMSSLS REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS
      2350
GSSRLGRIGQ RKHLVLN         10         20         30         40         50         60
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP VTDPFAFSRQ
        70         80         90        100        110        120
ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR DSSQGPCEPL PGPLTQPRAH
       130        140        150        160        170        180
ASPFSGALTP SAPPGPEMNR SAEVGPSSEP EVQTLPYLPH YIPGVDPETS HGGHPHGNMP
       190        200        210        220        230        240
GLDRPLSRQN PHDGVVTPAA SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG
       250        260        270        280        290        300
VPCATSVPHF PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
       310        320        330        340        350        360
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP LGAGAGSGCA
       370        380        390        400        410        420
PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF DDFCSSPGLG RPPAPTHVGA
       430        440        450        460        470        480
GSLCQALLPG PSNEAAGDVW GDTASTGVPD ASGSQYENVE NLEFVQNQEV LPSEPLNLDP
       490        500        510        520        530        540
SSPSDQFRYG PLPGPAVPRH GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ
       550        560        570        580        590        600
ELVGTFIQQE VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
       610        620        630        640        650        660
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA LPDASPGNLE
       670        680        690        700        710        720
QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV YPAPEKRPSA RTQGPVKCES
       730        740        750        760        770        780
PATTLWAQSE LPDFGGNVLL APAAPALYVC AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ
       790        800        810        820        830        840
SRGGIGASEN LENPPKMGEE EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA
       850        860        870        880        890        900
QPINFSVSLS NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
       910        920        930        940        950        960
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA LPGFANSPAG
       970        980        990       1000       1010       1020
STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR TLENPVNVYN PSHSDSLASQ
      1030       1040       1050       1060       1070       1080
QSVASHPRQS GPGAPNLDRF YQQVTKDAQG QPGLERAQQE LVPPQQQASP PQLPKAMFSE
      1090       1100       1110       1120       1130       1140
LSNPESLPAQ GQAQNSAQSP ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW
      1150       1160       1170       1180       1190       1200
PQPVPALAPG PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
      1210       1220       1230       1240       1250       1260
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS SQSDYYASYY
      1270       1280       1290       1300       1310       1320
SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY RREHSAFGDR PEKRDNNWRY
      1330       1340       1350       1360       1370       1380
DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS EHSARSLHSA HSLASRRSSL SSHSHQSQIY
      1390       1400       1410       1420       1430       1440
RSHNVAAGSY EAPLPPGSFH GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT
      1450       1460       1470       1480       1490       1500
SPEKFSVPHV CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
      1510       1520       1530       1540       1550       1560
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT VVGTDIAELL
      1570       1580       1590       1600       1610       1620
LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL SFLTGGPAAA ASSLERETER
      1630       1640       1650       1660       1670       1680
FRELLLYGRK KDALESAMKN GLWGHALLLA SKMDSRTHAR VMTRFANSLP INDPLQTVYQ
      1690       1700       1710       1720       1730       1740
LMSGRMPAAS TCCGDEKWGD WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH
      1750       1760       1770       1780       1790       1800
FCYLMAQAGF GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
      1810       1820       1830       1840       1850       1860
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ MASQLRLFDP
      1870       1880       1890       1900       1910       1920
QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL PQQCPGTPSS EMEQLDRPGL
      1930       1940       1950       1960       1970       1980
SQPGALGIAN PLLAVPAPSP EHSSPSVRLL PSAPQTLPDG PLASPARVPM FPVPLPPGPL
      1990       2000       2010       2020       2030       2040
EPGPGCVTPG PALGFLEPSG PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE
      2050       2060       2070       2080       2090       2100
LSEENFDGKF ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
      2110       2120       2130       2140       2150       2160
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK KAPPPPPTSM
      2170       2180       2190       2200       2210       2220
PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS GTQRSEPALA PADFVAPLAP
      2230       2240       2250       2260       2270       2280
LPIPSNLFVP TPDAEEPQLP DGTGREGPAA ARGLANPEPA PEPKVLSSAA SLPGSELPSS
      2290       2300       2310       2320       2330       2340
RPEGSQGGEL SRCSSMSSLS REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS
      2350
GSSRLGRIGQ RKHLVLN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

23 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15027-1-unknown	MQPPPQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15027-1-unknown	MQPPPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88912
O15027-1-unknown	MQPPPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88913
O15027-1-unknown	MQPPPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88914
O15027-1-unknown	MQPPPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88915
O15027-16-	PPAGNP...	16		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15027-16-unknown	PPAGNP...	16	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175106
O15027-16-unknown	PPAGNP...	16	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175107
O15027-16-unknown	PPAGNP...	16	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175108
O15027-16-unknown	PPAGNP...	16	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175109
O15027-197-unknown	TPAASP...	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170437
O15027-197-unknown	TPAASP...	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170438
O15027-197-unknown	TPAASP...	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170439
O15027-197-unknown	TPAASP...	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170440
O15027-197-	TPAASP...	197		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15027-342-unknown	SPENRT...	342		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O15027-342-unknown	SPENRT...	342	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162078
O15027-342-unknown	SPENRT...	342	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162079
O15027-342-unknown	SPENRT...	342	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162080
O15027-342-unknown	SPENRT...	342	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162081
O15027-342-	SPENRT...	342		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O15027-342-	SPENRT...	342		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15027-342-	SPENRT...	342		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15027-503-unknown	VCHTGA...	503	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167413
O15027-503-unknown	VCHTGA...	503	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167414
O15027-503-unknown	VCHTGA...	503	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167415
O15027-503-unknown	VCHTGA...	503	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167416
O15027-503-	VCHTGA...	503		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O15027-838-unknown	NLAQPI...	838		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O15027-838-unknown	NLAQPI...	838	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162073
O15027-838-unknown	NLAQPI...	838	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162074
O15027-838-unknown	NLAQPI...	838	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162075
O15027-838-unknown	NLAQPI...	838	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162076
O15027-838-	NLAQPI...	838		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O15027-838-	NLAQPI...	838		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15027-838-	NLAQPI...	838		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15027-838-	NLAQPI...	838		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O15027-840-unknown	AQPINF...	840	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170447
O15027-840-unknown	AQPINF...	840	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170448
O15027-840-unknown	AQPINF...	840	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170449
O15027-840-unknown	AQPINF...	840	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170450
O15027-840-	AQPINF...	840		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15027-1101-unknown	ASLVLV...	1101	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000403525
O15027-1101-unknown	ASLVLV...	1101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132245
O15027-1101-unknown	ASLVLV...	1101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132246
O15027-1101-unknown	ASLVLV...	1101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132247
O15027-1101-unknown	ASLVLV...	1101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132248
O15027-1429-unknown	WPAMEQ...	1429	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000277537
O15027-1429-unknown	WPAMEQ...	1429	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132240
O15027-1429-unknown	WPAMEQ...	1429	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132241
O15027-1429-unknown	WPAMEQ...	1429	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132242
O15027-1429-unknown	WPAMEQ...	1429	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt132243
O15027-1756-	KTTKLV...	1756		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O15027-1756-	KTTKLV...	1756		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O15027-1756-	KTTKLV...	1756		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O15027-1756-unknown	KTTKLV...	1756		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O15027-1756-unknown	KTTKLV...	1756	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160248
O15027-1756-unknown	KTTKLV...	1756	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160249
O15027-1756-unknown	KTTKLV...	1756	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160250
O15027-1756-unknown	KTTKLV...	1756	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160251
O15027-1859-unknown	DPQLKE...	1859	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170442
O15027-1859-unknown	DPQLKE...	1859	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170443
O15027-1859-unknown	DPQLKE...	1859	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170444
O15027-1859-unknown	DPQLKE...	1859	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170445
O15027-1859-	DPQLKE...	1859		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15027-1895-	HQDGAL...	1895		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15027-1895-unknown	HQDGAL...	1895	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175111
O15027-1895-unknown	HQDGAL...	1895	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175112
O15027-1895-unknown	HQDGAL...	1895	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175113
O15027-1895-unknown	HQDGAL...	1895	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175114
O15027-2075-	PTQPPL...	2075		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15027-2075-unknown	PTQPPL...	2075	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173339
O15027-2075-unknown	PTQPPL...	2075	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173338

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PGAPVN	2179	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PGAPVN	2179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84530
...PGAPVN	2179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84532
...PGAPVN	2179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84531
...PGAPVN	2179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84533

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)