O15234: Protein CASC3

General Information

Protein names	- Protein CASC3 - Cancer susceptibility candidate gene 3 protein - Metastatic lymph node gene 51 protein {ECO:0000303\|PubMed:12080473} - MLN 51 - Protein barentsz - Btz
Gene names	CASC3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15234

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADRRRQRAS QDTEDEESGA SGSDSGGSPL RGGGSCSGSA GGGGSGSLPS QRGGRTGALH
        70         80         90        100        110        120
LRRVESGGAK SAEESECESE DGIEGDAVLS DYESAEDSEG EEGEYSEEEN SKVELKSEAN
       130        140        150        160        170        180
DAVNSSTKEE KGEEKPDTKS TVTGERQSGD GQESTEPVEN KVGKKGPKHL DDDEDRKNPA
       190        200        210        220        230        240
YIPRKGLFFE HDLRGQTQEE EVRPKGRQRK LWKDEGRWEH DKFREDEQAP KSRQELIALY
       250        260        270        280        290        300
GYDIRSAHNP DDIKPRRIRK PRYGSPPQRD PNWNGERLNK SHRHQGLGGT LPPRTFINRN
       310        320        330        340        350        360
AAGTGRMSAP RNYSRSGGFK EGRAGFRPVE AGGQHGGRSG ETVKHEISYR SRRLEQTSVR
       370        380        390        400        410        420
DPSPEADAPV LGSPEKEEAA SEPPAAAPDA APPPPDRPIE KKSYSRARRT RTKVGDAVKL
       430        440        450        460        470        480
AEEVPPPPEG LIPAPPVPET TPTPPTKTGT WEAPVDSSTS GLEQDVAQLN IAEQNWSPGQ
       490        500        510        520        530        540
PSFLQPRELR GMPNHIHMGA GPPPQFNRME EMGVQGGRAK RYSSQRQRPV PEPPAPPVHI
       550        560        570        580        590        600
SIMEGHYYDP LQFQGPIYTH GDSPAPLPPQ GMLVQPGMNL PHPGLHPHQT PAPLPNPGLY
       610        620        630        640        650        660
PPPVSMSPGQ PPPQQLLAPT YFSAPGVMNF GNPSYPYAPG ALPPPPPPHL YPNTQAPSQV
       670        680        690        700
YGGVTYYNPA QQQVQPKPSP PRRTPQPVTI KPPPPEVVSR GSS

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15234-1-unknown	MADRRR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15234-390-unknown	AAPPPP...	390		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O15234-390-	AAPPPP...	390		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O15234-390-	AAPPPP...	390		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O15234-390-	AAPPPP...	390		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15234-390-	AAPPPP...	390		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15234-390-	AAPPPP...	390		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O15234-390-	AAPPPP...	390		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...GEEKPD	136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467654
	...SRGSS	703	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)