O15371: Eukaryotic translation initiation factor 3 subunit D {ECO:0000255|HAMAP-Rule:MF_03003}

General Information

Protein names	- Eukaryotic translation initiation factor 3 subunit D {ECO:0000255\|HAMAP-Rule:MF_03003} - eIF3d {ECO:0000255\|HAMAP-Rule:MF_03003} - Eukaryotic translation initiation factor 3 subunit 7 {ECO:0000255\|HAMAP-Rule:MF_03003} - eIF-3-zeta {ECO:0000255\|HAMAP-Rule:MF_03003} - eIF3 p66
Gene names	EIF3D
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15371

3 N-termini

6 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 3 subunit D - Isoform 3 of Eukaryotic translation initiation factor 3 subunit D

Sequence View

        10         20         30         40         50         60
MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS
        70         80         90        100        110        120
SQFGGGSQYA YFHEEDESSF QLVDTARTQK TAYQRNRMRF AQRNLRRDKD RRNMLQFNLQ
       130        140        150        160        170        180
ILPKSAKQKE RERIRLQKKF QKQFGVRQKW DQKSQKPRDS SVEVRSDWEV KEEMDFPQLM
       190        200        210        220        230        240
KMRYLEVSEP QDIECCGALE YYDKAFDRIT TRSEKPLRSI KRIFHTVTTT DDPVIRKLAK
       250        260        270        280        290        300
TQGNVFATDA ILATLMSCTR SVYSWDIVVQ RVGSKLFFDK RDNSDFDLLT VSETANEPPQ
       310        320        330        340        350        360
DEGNSFNSPR NLAMEATYIN HNFSQQCLRM GKERYNFPNP NPFVEDDMDK NEIASVAYRY
       370        380        390        400        410        420
RRWKLGDDID LIVRCEHDGV MTGANGEVSF INIKTLNEWD SRHCNGVDWR QKLDSQRGAV
       430        440        450        460        470        480
IATELKNNSY KLARWTCCAL LAGSEYLKLG YVSRYHVKDS SRHVILGTQQ FKPNEFASQI
       490        500        510        520        530        540
NLSVENAWGI LRCVIDICMK LEEGKYLILK DPNKQVIRVY SLPDGTFSSD EDEEEEEEEE

EEEEEEET         10         20         30         40         50         60
MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS
        70         80         90        100        110        120
SQFGGGSQYA YFHEEDESSF QLVDTARTQK TAYQRNRMRF AQRNLRRDKD RRNMLQFNLQ
       130        140        150        160        170        180
ILPKSAKQKE RERIRLQKKF QKQFGVRQKW DQKSQKPRDS SVEVRSDWEV KEEMDFPQLM
       190        200        210        220        230        240
KMRYLEVSEP QDIECCGALE YYDKAFDRIT TRSEKPLRSI KRIFHTVTTT DDPVIRKLAK
       250        260        270        280        290        300
TQGNVFATDA ILATLMSCTR SVYSWDIVVQ RVGSKLFFDK RDNSDFDLLT VSETANEPPQ
       310        320        330        340        350        360
DEGNSFNSPR NLAMEATYIN HNFSQQCLRM GKERYNFPNP NPFVEDDMDK NEIASVAYRY
       370        380        390        400        410        420
RRWKLGDDID LIVRCEHDGV MTGANGEVSF INIKTLNEWD SRHCNGVDWR QKLDSQRGAV
       430        440        450        460        470        480
IATELKNNSY KLARWTCCAL LAGSEYLKLG YVSRYHVKDS SRHVILGTQQ FKPNEFASQI
       490        500        510        520        530        540
NLSVENAWGI LRCVIDICMK LEEGKYLILK DPNKQVIRVY SLPDGTFSSD EDEEEEEEEE

EEEEEEET

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 6 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O15371-1-unknown	MAKFMT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O15371-116-unknown	QFNLQI...	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13725
O15371-247-unknown	ATDAIL...	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13726

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRNMLQ	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13725
...LQILPK	123	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000385212
...EVKEEM	173	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403584
...QGNVFA	246	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13726
...WDIVVQ	269	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390438
...EEEET	548	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	115	NMLQ.\|.QFNL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	246	NVFA.\|.ATDA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)