O35343: Importin subunit alpha-3

General Information

Protein names	- Importin subunit alpha-3 - Importin alpha Q1 - Qip1 - Karyopherin subunit alpha-4
Gene names	Kpna4
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O35343

5 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN VPQEDICEDS
        70         80         90        100        110        120
DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV
       130        140        150        160        170        180
HCLERDDNPS LQFEAAWALT NIASGTSEQT QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA
       190        200        210        220        230        240
LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI
       250        260        270        280        290        300
QEILPALCVL IHHTDVNILV DTVWALSYLT DAGNEQIQMV IDSGIVPHLV PLLSHQEVKV
       310        320        330        340        350        360
QTAALRAVGN IVTGTDEQTQ VVLNCDALSH FPALLTHPKE KINKEAVWFL SNITAGNQQQ
       370        380        390        400        410        420
VQAVIDANLV PMIIHLLDKG DFGTQKEAAW AISNLTISGR KDQVAYLIQQ NVIPPFCNLL
       430        440        450        460        470        480
TVKDAQVVQV VLDGLSNILK MAEDQAETIA NLIEECGGLE KIEQLQNHEN EDIYKLAYEI
       490        500        510        520
IDQFFSSDDI DEDPSLVPES VQGGTFGFNS STNVPTEGFQ F

Isoforms

Sequence View

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Directness:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
O35343-2-unknown	MADNEK...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
O35343-2-unknown	MADNEK...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O35343-2-Acetylation	ADNEKL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O35343-2-Acetylation	ADNEKL...	2	acetylation-		unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
O35343-2-Acetylation	ADNEKL...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
O35343-25-unknown	MRRQRN...	25		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000121076
O35343-60-unknown	SDIDGD...	60		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32287
O35343-76-unknown	IVQNAS...	76		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29518

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DICEDS	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32287
...TSLEAI	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29518
...LQFEAA	135	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000121076
...EGFQF	521	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	59	CEDS.\|.SDID	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATE_MOUSE	75	LEAI.\|.IVQN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IMA3_MOUSE @75

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)