O43314: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

General Information

Protein names	- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 - 2.7.4.21 {ECO:0000269\|PubMed:21222653} - 2.7.4.24 {ECO:0000269\|PubMed:21222653} - Diphosphoinositol pentakisphosphate kinase 2 - Histidine acid phosphatase domain-containing protein 1 - InsP6 and PP-IP5 kinase 2 - VIP1 homolog 2 - hsVIP2
Gene names	PPIP5K2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43314

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEAPRFFVG PEDTEINPGN YRHFFHHADE DDEEEDDSPP ERQIVVGICS MAKKSKSKPM
        70         80         90        100        110        120
KEILERISLF KYITVVVFEE EVILNEPVEN WPLCDCLISF HSKGFPLDKA VAYAKLRNPF
       130        140        150        160        170        180
VINDLNMQYL IQDRREVYSI LQAEGILLPR YAILNRDPNN PKECNLIEGE DHVEVNGEVF
       190        200        210        220        230        240
QKPFVEKPVS AEDHNVYIYY PTSAGGGSQR LFRKIGSRSS VYSPESNVRK TGSYIYEEFM
       250        260        270        280        290        300
PTDGTDVKVY TVGPDYAHAE ARKSPALDGK VERDSEGKEV RYPVILNARE KLIAWKVCLA
       310        320        330        340        350        360
FKQTVCGFDL LRANGQSYVC DVNGFSFVKN SMKYYDDCAK ILGNIVMREL APQFHIPWSI
       370        380        390        400        410        420
PLEAEDIPIV PTTSGTMMEL RCVIAVIRHG DRTPKQKMKM EVRHQKFFDL FEKCDGYKSG
       430        440        450        460        470        480
KLKLKKPKQL QEVLDIARQL LMELGQNNDS EIEENKPKLE QLKTVLEMYG HFSGINRKVQ
       490        500        510        520        530        540
LTYLPHGCPK TSSEEEDSRR EEPSLLLVLK WGGELTPAGR VQAEELGRAF RCMYPGGQGD
       550        560        570        580        590        600
YAGFPGCGLL RLHSTYRHDL KIYASDEGRV QMTAAAFAKG LLALEGELTP ILVQMVKSAN
       610        620        630        640        650        660
MNGLLDSDSD SLSSCQQRVK ARLHEILQKD RDFTAEDYEK LTPSGSISLI KSMHLIKNPV
       670        680        690        700        710        720
KTCDKVYSLI QSLTSQIRHR MEDPKSSDIQ LYHSETLELM LRRWSKLEKD FKTKNGRYDI
       730        740        750        760        770        780
SKIPDIYDCI KYDVQHNGSL KLENTMELYR LSKALADIVI PQEYGITKAE KLEIAKGYCT
       790        800        810        820        830        840
PLVRKIRSDL QRTQDDDTVN KLHPVYSRGV LSPERHVRTR LYFTSESHVH SLLSILRYGA
       850        860        870        880        890        900
LCNESKDEQW KRAMDYLNVV NELNYMTQIV IMLYEDPNKD LSSEERFHVE LHFSPGAKGC
       910        920        930        940        950        960
EEDKNLPSGY GYRPASRENE GRRPFKIDND DEPHTSKRDE VDRAVILFKP MVSEPIHIHR
       970        980        990       1000       1010       1020
KSPLPRSRKT ATNDEESPLS VSSPEGTGTW LHYTSGVGTG RRRRRSGEQI TSSPVSPKSL
      1030       1040       1050       1060       1070       1080
AFTSSIFGSW QQVVSENANY LRTPRTLVEQ KQNPTVGSHC AGLFSTSVLG GSSSAPNLQD
      1090       1100       1110       1120       1130       1140
YARTHRKKLT SSGCIDDATR GSAVKRFSIS FARHPTNGFE LYSMVPSICP LETLHNALSL
      1150       1160       1170       1180       1190       1200
KQVDEFLASI ASPSSDVPRK TAEISSTALR SSPIMRKKVS LNTYTPAKIL PTPPATLKST
      1210       1220       1230       1240
KASSKPATSG PSSAVVPNTS SRKKNITSKT ETHEHKKNTG KKK

Isoforms

- Isoform 2 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Sequence View

        10         20         30         40         50         60
MSEAPRFFVG PEDTEINPGN YRHFFHHADE DDEEEDDSPP ERQIVVGICS MAKKSKSKPM
        70         80         90        100        110        120
KEILERISLF KYITVVVFEE EVILNEPVEN WPLCDCLISF HSKGFPLDKA VAYAKLRNPF
       130        140        150        160        170        180
VINDLNMQYL IQDRREVYSI LQAEGILLPR YAILNRDPNN PKECNLIEGE DHVEVNGEVF
       190        200        210        220        230        240
QKPFVEKPVS AEDHNVYIYY PTSAGGGSQR LFRKIGSRSS VYSPESNVRK TGSYIYEEFM
       250        260        270        280        290        300
PTDGTDVKVY TVGPDYAHAE ARKSPALDGK VERDSEGKEV RYPVILNARE KLIAWKVCLA
       310        320        330        340        350        360
FKQTVCGFDL LRANGQSYVC DVNGFSFVKN SMKYYDDCAK ILGNIVMREL APQFHIPWSI
       370        380        390        400        410        420
PLEAEDIPIV PTTSGTMMEL RCVIAVIRHG DRTPKQKMKM EVRHQKFFDL FEKCDGYKSG
       430        440        450        460        470        480
KLKLKKPKQL QEVLDIARQL LMELGQNNDS EIEENKPKLE QLKTVLEMYG HFSGINRKVQ
       490        500        510        520        530        540
LTYLPHGCPK TSSEEEDSRR EEPSLLLVLK WGGELTPAGR VQAEELGRAF RCMYPGGQGD
       550        560        570        580        590        600
YAGFPGCGLL RLHSTYRHDL KIYASDEGRV QMTAAAFAKG LLALEGELTP ILVQMVKSAN
       610        620        630        640        650        660
MNGLLDSDSD SLSSCQQRVK ARLHEILQKD RDFTAEDYEK LTPSGSISLI KSMHLIKNPV
       670        680        690        700        710        720
KTCDKVYSLI QSLTSQIRHR MEDPKSSDIQ LYHSETLELM LRRWSKLEKD FKTKNGRYDI
       730        740        750        760        770        780
SKIPDIYDCI KYDVQHNGSL KLENTMELYR LSKALADIVI PQEYGITKAE KLEIAKGYCT
       790        800        810        820        830        840
PLVRKIRSDL QRTQDDDTVN KLHPVYSRGV LSPERHVRTR LYFTSESHVH SLLSILRYGA
       850        860        870        880        890        900
LCNESKDEQW KRAMDYLNVV NELNYMTQIV IMLYEDPNKD LSSEERFHVE LHFSPGAKGC
       910        920        930        940        950        960
EEDKNLPSGY GYRPASRENE GRRPFKIDND DEPHTSKRDE VDRAVILFKP MVSEPIHIHR
       970        980        990       1000       1010       1020
KSPLPRSRKT ATNDEESPLS VSSPEGTGTW LHYTSGVGTG RRRRRSGEQI TSSPVSPKSL
      1030       1040       1050       1060       1070       1080
AFTSSIFGSW QQVVSENANY LRTPRTLVEQ KQNPTVGSHC AGLFSTSVLG GSSSAPNLQD
      1090       1100       1110       1120       1130       1140
YARTHRKKLT SSGCIDDATR GSAVKRFSIS FARHPTNGFE LYSMVPSICP LETLHNALSL
      1150       1160       1170       1180       1190       1200
KQVDEFLASI ASPSSDVPRK TAEISSTALR SSPIMRKKVS LNTYTPAKIL PTPPATLKST
      1210       1220       1230       1240
KASSKPATSG PSSAVVPNTS SRKKNITSKT ETHEHKKNTG KKK

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43314-1-unknown	MSEAPR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43314-1-unknown	MSEAPR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94168
O43314-251-unknown	TVGPDY...	251	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178309
O43314-251-	TVGPDY...	251		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43314-275-unknown	SEGKEV...	275	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10739
O43314-275-unknown	SEGKEV...	275	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149239

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KVERDS	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10739
...KVERDS	274	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132624
...TGKKK	1243	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TGKKK	1243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89786

TopFIND

O43314: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

General Information

4

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates