O60566: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Protein names | - Mitotic checkpoint serine/threonine-protein kinase BUB1 beta - 2.7.11.1 - MAD3/BUB1-related protein kinase - hBUBR1 - Mitotic checkpoint kinase MAD3L - Protein SSK1 |
---|---|
Gene names | BUB1B |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O60566 |
4
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA CNNTLQQQKR
70 80 90 100 110 120
AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST LLERAVEALQ GEKRYYSDPR
130 140 150 160 170 180
FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS LAQFYISWAE EYEARENFRK ADAIFQEGIQ
190 200 210 220 230 240
QKAEPLERLQ SQHRQFQARV SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA
250 260 270 280 290 300
PIIRVGGALK APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM
310 320 330 340 350 360
PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETARQ PVMTPCKIEP
370 380 390 400 410 420
SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK EKIYAGVGEF SFEEIRAEVF
430 440 450 460 470 480
RKKLKEQREA ELLTSAEKRA EMQKQIEEME KKLKEIQTTQ QERTGDQQEE TMPTKETTKL
490 500 510 520 530 540
QIASESQKIP GMTLSSSVCQ VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK
550 560 570 580 590 600
NKSPPADPPR VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT
610 620 630 640 650 660
ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE DQQTACGTIY
670 680 690 700 710 720
SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC LQIPEKLELT NETSENPTQS
730 740 750 760 770 780
PWCSQYRRQL LKSLPELSAS AELCIEDRPM PKLEIEKEIE LGNEDYCIKR EYLICEDYKL
790 800 810 820 830 840
FWVAPRNSAE LTVIKVSSQP VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN
850 860 870 880 890 900
CFTLQDLLQH SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC
910 920 930 940 950 960
NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ VDLFGIADLA
970 980 990 1000 1010 1020
HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI LNANDEATVS VLGELAAEMN
1030 1040 1050
GVFDTTFQSH LNKALWKVGK LTSPGALLFQ
Isoforms
- Isoform 2 of Mitotic checkpoint serine/threonine-protein kinase BUB1 beta - Isoform 3 of Mitotic checkpoint serine/threonine-protein kinase BUB1 betaSequence View
10 20 30 40 50 60
MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA CNNTLQQQKR
70 80 90 100 110 120
AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST LLERAVEALQ GEKRYYSDPR
130 140 150 160 170 180
FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS LAQFYISWAE EYEARENFRK ADAIFQEGIQ
190 200 210 220 230 240
QKAEPLERLQ SQHRQFQARV SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA
250 260 270 280 290 300
PIIRVGGALK APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM
310 320 330 340 350 360
PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETARQ PVMTPCKIEP
370 380 390 400 410 420
SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK EKIYAGVGEF SFEEIRAEVF
430 440 450 460 470 480
RKKLKEQREA ELLTSAEKRA EMQKQIEEME KKLKEIQTTQ QERTGDQQEE TMPTKETTKL
490 500 510 520 530 540
QIASESQKIP GMTLSSSVCQ VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK
550 560 570 580 590 600
NKSPPADPPR VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT
610 620 630 640 650 660
ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE DQQTACGTIY
670 680 690 700 710 720
SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC LQIPEKLELT NETSENPTQS
730 740 750 760 770 780
PWCSQYRRQL LKSLPELSAS AELCIEDRPM PKLEIEKEIE LGNEDYCIKR EYLICEDYKL
790 800 810 820 830 840
FWVAPRNSAE LTVIKVSSQP VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN
850 860 870 880 890 900
CFTLQDLLQH SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC
910 920 930 940 950 960
NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ VDLFGIADLA
970 980 990 1000 1010 1020
HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI LNANDEATVS VLGELAAEMN
1030 1040 1050
GVFDTTFQSH LNKALWKVGK LTSPGALLFQ
10 20 30 40 50 60
MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA CNNTLQQQKR
70 80 90 100 110 120
AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST LLERAVEALQ GEKRYYSDPR
130 140 150 160 170 180
FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS LAQFYISWAE EYEARENFRK ADAIFQEGIQ
190 200 210 220 230 240
QKAEPLERLQ SQHRQFQARV SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA
250 260 270 280 290 300
PIIRVGGALK APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM
310 320 330 340 350 360
PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETARQ PVMTPCKIEP
370 380 390 400 410 420
SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK EKIYAGVGEF SFEEIRAEVF
430 440 450 460 470 480
RKKLKEQREA ELLTSAEKRA EMQKQIEEME KKLKEIQTTQ QERTGDQQEE TMPTKETTKL
490 500 510 520 530 540
QIASESQKIP GMTLSSSVCQ VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK
550 560 570 580 590 600
NKSPPADPPR VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT
610 620 630 640 650 660
ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE DQQTACGTIY
670 680 690 700 710 720
SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC LQIPEKLELT NETSENPTQS
730 740 750 760 770 780
PWCSQYRRQL LKSLPELSAS AELCIEDRPM PKLEIEKEIE LGNEDYCIKR EYLICEDYKL
790 800 810 820 830 840
FWVAPRNSAE LTVIKVSSQP VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN
850 860 870 880 890 900
CFTLQDLLQH SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC
910 920 930 940 950 960
NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ VDLFGIADLA
970 980 990 1000 1010 1020
HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI LNANDEATVS VLGELAAEMN
1030 1040 1050
GVFDTTFQSH LNKALWKVGK LTSPGALLFQ
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O60566-1-unknown | MAAVKK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O60566-1-unknown | MAAVKK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt68760 | |||
O60566-1-unknown | MAAVKK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt68761 | |||
O60566-577-unknown | VCDEFT... | 577 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10833 | |||
O60566-577-unknown | VCDEFT... | 577 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153725 | |||
O60566-577-unknown | VCDEFT... | 577 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154475 | |||
O60566-627- | SLKDLP... | 627 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O60566-627-unknown | SLKDLP... | 627 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168328 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...DVSPDV | 576 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10833 | |||
...DVSPDV | 576 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137148 | |||
...DVSPDV | 576 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137897 | |||
...ALLFQ | 1050 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...ALLFQ | 1050 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt64378 | |||
...ALLFQ | 1050 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt64379 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 576 | SPDV.|.VCDE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|