O60678: Protein arginine N-methyltransferase 3

General Information

Protein names	- Protein arginine N-methyltransferase 3 - 2.1.1.- - Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
Gene names	PRMT3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60678

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein arginine N-methyltransferase 3 - Isoform 2 of Protein arginine N-methyltransferase 3

Sequence View

        10         20         30         40         50         60
MCSLASGATG GRGAVENEED LPELSDSGDE AAWEDEDDAD LPHGKQQTPC LFCNRLFTSA
        70         80         90        100        110        120
EETFSHCKSE HQFNIDSMVH KHGLEFYGYI KLINFIRLKN PTVEYMNSIY NPVPWEKEEY
       130        140        150        160        170        180
LKPVLEDDLL LQFDVEDLYE PVSVPFSYPN GLSENTSVVE KLKHMEARAL SAEAALARAR
       190        200        210        220        230        240
EDLQKMKQFA QDFVMHTDVR TCSSSTSVIA DLQEDEDGVY FSSYGHYGIH EEMLKDKIRT
       250        260        270        280        290        300
ESYRDFIYQN PHIFKDKVVL DVGCGTGILS MFAAKAGAKK VLGVDQSEIL YQAMDIIRLN
       310        320        330        340        350        360
KLEDTITLIK GKIEEVHLPV EKVDVIISEW MGYFLLFESM LDSVLYAKNK YLAKGGSVYP
       370        380        390        400        410        420
DICTISLVAV SDVNKHADRI AFWDDVYGFK MSCMKKAVIP EAVVEVLDPK TLISEPCGIK
       430        440        450        460        470        480
HIDCHTTSIS DLEFSSDFTL KITRTSMCTA IAGYFDIYFE KNCHNRVVFS TGPQSTKTHW
       490        500        510        520        530
KQTVFLLEKP FSVKAGEALK GKVTVHKNKK DPRSLTVTLT LNNSTQTYGL Q         10         20         30         40         50         60
MCSLASGATG GRGAVENEED LPELSDSGDE AAWEDEDDAD LPHGKQQTPC LFCNRLFTSA
        70         80         90        100        110        120
EETFSHCKSE HQFNIDSMVH KHGLEFYGYI KLINFIRLKN PTVEYMNSIY NPVPWEKEEY
       130        140        150        160        170        180
LKPVLEDDLL LQFDVEDLYE PVSVPFSYPN GLSENTSVVE KLKHMEARAL SAEAALARAR
       190        200        210        220        230        240
EDLQKMKQFA QDFVMHTDVR TCSSSTSVIA DLQEDEDGVY FSSYGHYGIH EEMLKDKIRT
       250        260        270        280        290        300
ESYRDFIYQN PHIFKDKVVL DVGCGTGILS MFAAKAGAKK VLGVDQSEIL YQAMDIIRLN
       310        320        330        340        350        360
KLEDTITLIK GKIEEVHLPV EKVDVIISEW MGYFLLFESM LDSVLYAKNK YLAKGGSVYP
       370        380        390        400        410        420
DICTISLVAV SDVNKHADRI AFWDDVYGFK MSCMKKAVIP EAVVEVLDPK TLISEPCGIK
       430        440        450        460        470        480
HIDCHTTSIS DLEFSSDFTL KITRTSMCTA IAGYFDIYFE KNCHNRVVFS TGPQSTKTHW
       490        500        510        520        530
KQTVFLLEKP FSVKAGEALK GKVTVHKNKK DPRSLTVTLT LNNSTQTYGL Q

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60678-2-unknown	MCSLAS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60678-2-Acetylation	CSLASG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60678-2-Acetylation	CSLASG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O60678-2-Acetylation	CSLASG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O60678-2-Acetylation	CSLASG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60678-212-unknown	LQEDED...	212		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10836
O60678-212-unknown	LQEDED...	212		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144726

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SVIADL	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10836
...SVIADL	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128001
...TYGLQ	531	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TYGLQ	531	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62602

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	211	IADL.\|.LQED	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)