O60869: Endothelial differentiation-related factor 1

General Information

Protein names	- Endothelial differentiation-related factor 1 - EDF-1 - Multiprotein-bridging factor 1 - MBF1
Gene names	EDF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60869

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Endothelial differentiation-related factor 1 - Isoform 3 of Endothelial differentiation-related factor 1

Sequence View

        10         20         30         40         50         60
MAESDWDTVT VLRKKGPTAA QAKSKQAILA AQRRGEDVET SKKWAAGQNK QHSITKNTAK
        70         80         90        100        110        120
LDRETEELHH DRVTLEVGKV IQQGRQSKGL TQKDLATKIN EKPQVIADYE SGRAIPNNQV
       130        140
LGKIERAIGL KLRGKDIGKP IEKGPRAK         10         20         30         40         50         60
MAESDWDTVT VLRKKGPTAA QAKSKQAILA AQRRGEDVET SKKWAAGQNK QHSITKNTAK
        70         80         90        100        110        120
LDRETEELHH DRVTLEVGKV IQQGRQSKGL TQKDLATKIN EKPQVIADYE SGRAIPNNQV
       130        140
LGKIERAIGL KLRGKDIGKP IEKGPRAK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60869-1-unknown	MAESDW...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73630
O60869-1-unknown	MAESDW...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73631
O60869-2-unknown	MAESDW...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60869-2-Acetylation	AESDWD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60869-2-Acetylation	AESDWD...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O60869-2-Acetylation	AESDWD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60869-2-Acetylation	AESDWD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110448
O60869-2-Acetylation	AESDWD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110449
O60869-19-unknown	AAQAKS...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13781
O60869-19-unknown	AAQAKS...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136805
O60869-19-unknown	AAQAKS...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136806
O60869-24-unknown	SKQAIL...	24		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169974
O60869-24-unknown	SKQAIL...	24		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169975
O60869-24-	SKQAIL...	24			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O60869-24-	SKQAIL...	24			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O60869-24-	SKQAIL...	24			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KKGPTA	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13781
	...GPRAK	148	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	18	GPTA.\|.AAQA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)