O75330: Hyaluronan mediated motility receptor

General Information

Protein names	- Hyaluronan mediated motility receptor - Intracellular hyaluronic acid-binding protein - Receptor for hyaluronan-mediated motility - CD168
Gene names	HMMR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75330

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Hyaluronan mediated motility receptor - Isoform 3 of Hyaluronan mediated motility receptor - Isoform 4 of Hyaluronan mediated motility receptor

Sequence View

        10         20         30         40         50         60
MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES KQNLNVDKDT
        70         80         90        100        110        120
TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA QDRRIQDLET ELEKMEARLN
       130        140        150        160        170        180
AALREKTSLS ANNATLEKQL IELTRTNELL KSKFSENGNQ KNLRILSLEL MKLRNKRETK
       190        200        210        220        230        240
MRGMMAKQEG MEMKLQVTQR SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI
       250        260        270        280        290        300
SCASDQVEKY KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK
       310        320        330        340        350        360
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK ELSSSLHQKL
       370        380        390        400        410        420
CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK QLEEEAKSRA EELKLLEEKL
       430        440        450        460        470        480
KGKEAELEKS SAAHTQATLL LQEKYDSMVQ SLEDVTAQFE SYKALTASEI EDLKLENSSL
       490        500        510        520        530        540
QEKAAKAGKN AEDVQHQILA TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL
       550        560        570        580        590        600
QNQLKQQEED FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF
       610        620        630        640        650        660
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ LKSEVSKLRC
       670        680        690        700        710        720
QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA LKTPLKEGNT NCYRAPMECQ

ESWK         10         20         30         40         50         60
MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES KQNLNVDKDT
        70         80         90        100        110        120
TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA QDRRIQDLET ELEKMEARLN
       130        140        150        160        170        180
AALREKTSLS ANNATLEKQL IELTRTNELL KSKFSENGNQ KNLRILSLEL MKLRNKRETK
       190        200        210        220        230        240
MRGMMAKQEG MEMKLQVTQR SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI
       250        260        270        280        290        300
SCASDQVEKY KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK
       310        320        330        340        350        360
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK ELSSSLHQKL
       370        380        390        400        410        420
CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK QLEEEAKSRA EELKLLEEKL
       430        440        450        460        470        480
KGKEAELEKS SAAHTQATLL LQEKYDSMVQ SLEDVTAQFE SYKALTASEI EDLKLENSSL
       490        500        510        520        530        540
QEKAAKAGKN AEDVQHQILA TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL
       550        560        570        580        590        600
QNQLKQQEED FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF
       610        620        630        640        650        660
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ LKSEVSKLRC
       670        680        690        700        710        720
QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA LKTPLKEGNT NCYRAPMECQ

ESWK         10         20         30         40         50         60
MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES KQNLNVDKDT
        70         80         90        100        110        120
TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA QDRRIQDLET ELEKMEARLN
       130        140        150        160        170        180
AALREKTSLS ANNATLEKQL IELTRTNELL KSKFSENGNQ KNLRILSLEL MKLRNKRETK
       190        200        210        220        230        240
MRGMMAKQEG MEMKLQVTQR SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI
       250        260        270        280        290        300
SCASDQVEKY KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK
       310        320        330        340        350        360
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK ELSSSLHQKL
       370        380        390        400        410        420
CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK QLEEEAKSRA EELKLLEEKL
       430        440        450        460        470        480
KGKEAELEKS SAAHTQATLL LQEKYDSMVQ SLEDVTAQFE SYKALTASEI EDLKLENSSL
       490        500        510        520        530        540
QEKAAKAGKN AEDVQHQILA TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL
       550        560        570        580        590        600
QNQLKQQEED FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF
       610        620        630        640        650        660
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ LKSEVSKLRC
       670        680        690        700        710        720
QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA LKTPLKEGNT NCYRAPMECQ

ESWK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75330-1-unknown	MSFPKA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75330-1-unknown	MSFPKA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77105
O75330-1-unknown	MSFPKA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77106
O75330-2-acetylation	SFPKAP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O75330-2-acetylation	SFPKAP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O75330-2-acetylation	SFPKAP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162649
O75330-2-acetylation	SFPKAP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162650
O75330-608-unknown	LNEHGA...	608		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13819
O75330-608-unknown	LNEHGA...	608		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153643
O75330-608-unknown	LNEHGA...	608		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154511
O75330-608-unknown	LNEHGA...	608		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154731

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKQALL	607	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13819
...EKQALL	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137067
...EKQALL	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137933
...EKQALL	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138157
...QESWK	724	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QESWK	724	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72725
...QESWK	724	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72723
...QESWK	724	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72724

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	607	QALL.\|.LNEH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)