O75340: Programmed cell death protein 6

General Information

Protein names	- Programmed cell death protein 6 - Apoptosis-linked gene 2 protein homolog {ECO:0000250\|UniProtKB:P12815} - ALG-2 {ECO:0000250\|UniProtKB:P12815}
Gene names	PDCD6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75340

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Programmed cell death protein 6 - Isoform 3 of Programmed cell death protein 6

Sequence View

        10         20         30         40         50         60
MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ ALSNGTWTPF
        70         80         90        100        110        120
NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR TYDRDNSGMI DKNELKQALS
       130        140        150        160        170        180
GFGYRLSDQF HDILIRKFDR QGRGQIAFDD FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY
       190
EQYLSMVFSI V         10         20         30         40         50         60
MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ ALSNGTWTPF
        70         80         90        100        110        120
NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR TYDRDNSGMI DKNELKQALS
       130        140        150        160        170        180
GFGYRLSDQF HDILIRKFDR QGRGQIAFDD FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY
       190
EQYLSMVFSI V

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
O75340-2-unknown	MAAYSY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75340-1-unknown	MAAYSY...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84640
O75340-1-unknown	MAAYSY...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84641
O75340-2-Acetylation	AAYSYR...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75340-2-Acetylation	AAYSYR...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O75340-2-Acetylation	AAYSYR...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110423
O75340-2-Acetylation	AAYSYR...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110424
O75340-107-unknown	SGMIDK...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16942

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VRSIIS	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80259
...VRSIIS	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91404
...YDRDNS	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16942
...YDRDNS	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125939
...VFSIV	191	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VFSIV	191	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80258

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	106	RDNS.\|.SGMI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)