O75496: Geminin

General Information

Protein names	- Geminin
Gene names	GMNN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75496

5 N-termini

6 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNPSMKQKQE EIKENIKNSS VPRRTLKMIQ PSASGSLVGR ENELSAGLSK RKHRNDHLTS
        70         80         90        100        110        120
TTSSPGVIVP ESSENKNLGG VTQESFDLMI KENPSSQYWK EVAEKRRKAL YEALKENEKL
       130        140        150        160        170        180
HKEIEQKDNE IARLKKENKE LAEVAEHVQY MAELIERLNG EPLDNFESLD NQEFDSEEET
       190        200
VEDSLVEDSE IGTCAEGTVS SSTDAKPCI

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 6 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75496-1-unknown	MNPSMK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75496-27-	KMIQPS...	27		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75496-28-	MIQPSA...	28		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75496-28-	MIQPSA...	28		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O75496-28-	MIQPSA...	28		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
O75496-28-	MIQPSA...	28		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O75496-28-	MIQPSA...	28		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75496-28-unknown	MIQPSA...	28	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
O75496-28-unknown	MIQPSA...	28		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75496-28-unknown	MIQPSA...	28		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75496-171-unknown	NQEFDS...	171	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1494

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TTSSPG	65	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419584
...YWKEVA	102	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000367298
...FESLDN	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1494
...DSEEET	179	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000367293
...SSSTDA	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1495
...AKPCI	209	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	170	SLDN.\|.NQEF	inferred from experiment	unknown	MEROPS	Lygerou Z	Roukos V et al.:Geminin cleavage during apoptos... (C14.003)	17261582,
CASP3_HUMAN	204	STDA.\|.AKPC	inferred from experiment	unknown	MEROPS	Lygerou Z	Roukos V et al.:Geminin cleavage during apoptos... (C14.003)	17261582,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)