O75530: Polycomb protein EED {ECO:0000305}

General Information

Protein names	- Polycomb protein EED {ECO:0000305} - hEED - Embryonic ectoderm development protein {ECO:0000303\|PubMed:28229514} - WD protein associating with integrin cytoplasmic tails 1 - WAIT-1
Gene names	EED
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75530

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Polycomb protein EED - Isoform 3 of Polycomb protein EED

Sequence View

        10         20         30         40         50         60
MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP
        70         80         90        100        110        120
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR
       130        140        150        160        170        180
VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM
       190        200        210        220        230        240
QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL
       250        260        270        280        290        300
SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS
       310        320        330        340        350        360
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ
       370        380        390        400        410        420
CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR
       430        440
DSSILIAVCD DASIWRWDRL R         10         20         30         40         50         60
MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP
        70         80         90        100        110        120
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR
       130        140        150        160        170        180
VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM
       190        200        210        220        230        240
QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL
       250        260        270        280        290        300
SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS
       310        320        330        340        350        360
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ
       370        380        390        400        410        420
CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR
       430        440
DSSILIAVCD DASIWRWDRL R

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
O75530-1-unknown	MSEREV...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73649
O75530-1-unknown	MSEREV...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73650
O75530-2-unknown	MSEREV...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O75530-2-Acetylation	SEREVS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O75530-2-Acetylation	SEREVS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110515
O75530-2-Acetylation	SEREVS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110516
O75530-143-unknown	ADENFY...	143		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10950
O75530-143-unknown	ADENFY...	143		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144458
O75530-143-unknown	ADENFY...	143		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144459

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YVDADA	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10950
...YVDADA	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127722
...YVDADA	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127723
...PHKAKC	400	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69268
...PHKAKC	400	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92663
...WDRLR	441	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WDRLR	441	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69267

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	142	DADA.\|.ADEN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)