O75874: Isocitrate dehydrogenase [NADP] cytoplasmic

General Information

Protein names	- Isocitrate dehydrogenase NADP] cytoplasmic - IDH - 1.1.1.42 {ECO:0000269\|PubMed:10521434, ECO:0000269\|PubMed:19935646} - Cytosolic NADP-isocitrate dehydrogenase - IDP - NADP(+)-specific ICDH - Oxalosuccinate decarboxylase
Gene names	IDH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75874

2 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSKKISGGSV VEMQGDEMTR IIWELIKEKL IFPYVELDLH SYDLGIENRD ATNDQVTKDA
        70         80         90        100        110        120
AEAIKKHNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL
       130        140        150        160        170        180
VSGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPSD GTQKVTYLVH NFEEGGGVAM
       190        200        210        220        230        240
GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE
       250        260        270        280        290        300
AQKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLVCPDG
       310        320        330        340        350        360
KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNK ELAFFANALE
       370        380        390        400        410
EVSIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKIKLA QAKL

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75874-2-unknown	MSKKIS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75874-2-Acetylation	SKKISG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75874-2-Acetylation	SKKISG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O75874-2-Acetylation	SKKISG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O75874-2-Acetylation	SKKISG...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KDAAEA	62	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396787
...VGVKCA	73	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409045
...EITYTP	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391075
...AQAKL	414	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)