O88554: Poly [ADP-ribose] polymerase 2
| Protein names | - Poly ADP-ribose] polymerase 2 - PARP-2 - mPARP-2 - 2.4.2.30 {ECO:0000250|UniProtKB:Q9UGN5} - ADP-ribosyltransferase diphtheria toxin-like 2 - ARTD2 - DNA ADP-ribosyltransferase PARP2 {ECO:0000305} - 2.4.2.- {ECO:0000250|UniProtKB:Q9UGN5} - NAD(+) ADP-ribosyltransferase 2 - ADPRT-2 - PolyADP-ribose] synthase 2 - pADPRT-2 - Protein poly-ADP-ribosyltransferase PARP2 {ECO:0000305} - 2.4.2.- {ECO:0000250|UniProtKB:Q9UGN5} |
|---|---|
| Gene names | Parp2 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | O88554 |
3
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAPRRQRSGS GRRVLNEAKK VDNGNKATED DSPPGKKMRT CQRKGPMAGG KDADRTKDNR
70 80 90 100 110 120
DSVKTLLLKG KAPVDPECAA KLGKAHVYCE GDDVYDVMLN QTNLQFNNNK YYLIQLLEDD
130 140 150 160 170 180
AQRNFSVWMR WGRVGKTGQH SLVTCSGDLN KAKEIFQKKF LDKTKNNWED RENFEKVPGK
190 200 210 220 230 240
YDMLQMDYAA STQDESKTKE EETLKPESQL DLRVQELLKL ICNVQTMEEM MIEMKYDTKR
250 260 270 280 290 300
APLGKLTVAQ IKAGYQSLKK IEDCIRAGQH GRALVEACNE FYTRIPHDFG LSIPPVIRTE
310 320 330 340 350 360
KELSDKVKLL EALGDIEIAL KLVKSERQGL EHPLDQHYRN LHCALRPLDH ESNEFKVISQ
370 380 390 400 410 420
YLQSTHAPTH KDYTMTLLDV FEVEKEGEKE AFREDLPNRM LLWHGSRLSN WVGILSHGLR
430 440 450 460 470 480
VAPPEAPITG YMFGKGIYFA DMSSKSANYC FASRLKNTGL LLLSEVALGQ CNELLEANPK
490 500 510 520 530 540
AQGLLRGKHS TKGMGKMAPS PAHFITLNGS TVPLGPASDT GILNPEGYTL NYNEFIVYSP
550
NQVRMRYLLK IQFNFLQLW
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| O88554-1-unknown | MAPRRQ... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| O88554-121-unknown | AQRNFS... | 121 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28607 | |||
| O88554-188-unknown | YAASTQ... | 188 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28608 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...LLEDDA | 120 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28607 | |||
| ...MLQMDY | 187 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28608 | |||
| ...FLQLW | 559 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CASP8_MOUSE | 120 | EDDA.|.AQRN | inferred from experiment | unknown | MEROPS | Onteniente B | Benchoua A et al.:Active caspase-8 translocates i... (C14.009) | 12065591, |
| CASP8_MOUSE | 187 | QMDY.|.YAAS | inferred from experiment | unknown | MEROPS | Onteniente B | Benchoua A et al.:Active caspase-8 translocates i... (C14.009) | 12065591, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|