O94842: TOX high mobility group box family member 4

General Information

Protein names	- TOX high mobility group box family member 4 - Epidermal Langerhans cell protein LCP1
Gene names	TOX4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O94842

5 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of TOX high mobility group box family member 4 - Isoform 3 of TOX high mobility group box family member 4

Sequence View

        10         20         30         40         50         60
MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL AVSDVVGHFD
        70         80         90        100        110        120
DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL SGGLTMDLDH SIGTQYSANP
       130        140        150        160        170        180
PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS SQLGLSLGGG TILPPAQSPE DRLSTTPSPT
       190        200        210        220        230        240
SSLHEDGVED FRRQLPSQKT VVVEAGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA
       250        260        270        280        290        300
IKGQNPNATF GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV
       310        320        330        340        350        360
ETVELDPAPP SQTPSPPPMA TVDPASPAPA SIEPPALSPS IVVNSTLSSY VANQASSGAG
       370        380        390        400        410        420
GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL QLGQTSTATI QPSQQAQIVT
       430        440        450        460        470        480
RSVLQAAAAA AAAASMQLPP PRLQPPPLQQ MPQPPTQQQV TILQQPPPLQ AMQQPPPQKV
       490        500        510        520        530        540
RINLQQQPPP LQIKSVPLPT LKMQTTLVPP TVESSPERPM NNSPEAHTVE APSPETICEM
       550        560        570        580        590        600
ITDVVPEVES PSQMDVELVS GSPVALSPQP RCVRSGCENP PIVSKDWDNE YCSNECVVKH
       610        620
CRDVFLAWVA SRNSNTVVFV K         10         20         30         40         50         60
MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL AVSDVVGHFD
        70         80         90        100        110        120
DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL SGGLTMDLDH SIGTQYSANP
       130        140        150        160        170        180
PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS SQLGLSLGGG TILPPAQSPE DRLSTTPSPT
       190        200        210        220        230        240
SSLHEDGVED FRRQLPSQKT VVVEAGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA
       250        260        270        280        290        300
IKGQNPNATF GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV
       310        320        330        340        350        360
ETVELDPAPP SQTPSPPPMA TVDPASPAPA SIEPPALSPS IVVNSTLSSY VANQASSGAG
       370        380        390        400        410        420
GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL QLGQTSTATI QPSQQAQIVT
       430        440        450        460        470        480
RSVLQAAAAA AAAASMQLPP PRLQPPPLQQ MPQPPTQQQV TILQQPPPLQ AMQQPPPQKV
       490        500        510        520        530        540
RINLQQQPPP LQIKSVPLPT LKMQTTLVPP TVESSPERPM NNSPEAHTVE APSPETICEM
       550        560        570        580        590        600
ITDVVPEVES PSQMDVELVS GSPVALSPQP RCVRSGCENP PIVSKDWDNE YCSNECVVKH
       610        620
CRDVFLAWVA SRNSNTVVFV K

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O94842-1-unknown	MEFPGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O94842-495-unknown	SVPLPT...	495	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177129
O94842-495-	SVPLPT...	495		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O94842-561-unknown	GSPVAL...	561		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O94842-561-unknown	GSPVAL...	561	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160365
O94842-561-	GSPVAL...	561		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EDFRRQ	193	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000402195
...EDFRRQ	193	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406196
...EDFRRQ	193	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt111278
...VVFVK	621		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...VVFVK	621	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VVFVK	621	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt88398
...VVFVK	621		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VVFVK	621		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)