O95049: Tight junction protein ZO-3

General Information

Protein names	- Tight junction protein ZO-3 - Tight junction protein 3 - Zona occludens protein 3 - Zonula occludens protein 3
Gene names	TJP3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95049

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 3 of Tight junction protein ZO-3 - Isoform 4 of Tight junction protein ZO-3 - Isoform 6 of Tight junction protein ZO-3

Sequence View

        10         20         30         40         50         60
MEELTIWEQH TATLSKDPRR GFGIAISGGR DRPGGSMVVS DVVPGGPAEG RLQTGDHIVM
        70         80         90        100        110        120
VNGVSMENAT SAFAIQILKT CTKMANITVK RPRRIHLPAT KASPSSPGRQ DSDEDDGPQR
       130        140        150        160        170        180
VEEVDQGRGY DGDSSSGSGR SWDERSRRPR PGRRGRAGSH GRRSPGGGSE ANGLALVSGF
       190        200        210        220        230        240
KRLPRQDVQM KPVKSVLVKR RDSEEFGVKL GSQIFIKHIT DSGLAARHRG LQEGDLILQI
       250        260        270        280        290        300
NGVSSQNLSL NDTRRLIEKS EGKLSLLVLR DRGQFLVNIP PAVSDSDSSP LEDISDLASE
       310        320        330        340        350        360
LSQAPPSHIP PPPRHAQRSP EASQTDSPVE SPRLRRESSV DSRTISEPDE QRSELPRESS
       370        380        390        400        410        420
YDIYRVPSSQ SMEDRGYSPD TRVVRFLKGK SIGLRLAGGN DVGIFVSGVQ AGSPADGQGI
       430        440        450        460        470        480
QEGDQILQVN DVPFQNLTRE EAVQFLLGLP PGEEMELVTQ RKQDIFWKMV QSRVGDSFYI
       490        500        510        520        530        540
RTHFELEPSP PSGLGFTRGD VFHVLDTLHP GPGQSHARGG HWLAVRMGRD LREQERGIIP
       550        560        570        580        590        600
NQSRAEQLAS LEAAQRAVGV GPGSSAGSNA RAEFWRLRGL RRGAKKTTQR SREDLSALTR
       610        620        630        640        650        660
QGRYPPYERV VLREASFKRP VVILGPVADI AMQKLTAEMP DQFEIAETVS RTDSPSKIIK
       670        680        690        700        710        720
LDTVRVIAEK DKHALLDVTP SAIERLNYVQ YYPIVVFFIP ESRPALKALR QWLAPASRRS
       730        740        750        760        770        780
TRRLYAQAQK LRKHSSHLFT ATIPLNGTSD TWYQELKAII REQQTRPIWT AEDQLDGSLE
       790        800        810        820        830        840
DNLDLPHHGL ADSSADLSCD SRVNSDYETD GEGGAYTDGE GYTDGEGGPY TDVDDEPPAP
       850        860        870        880        890        900
ALARSSEPVQ ADESQSPRDR GRISAHQGAQ VDSRHPQGQW RQDSMRTYER EALKKKFMRV
       910
HDAESSDEDG YDWGPATDL         10         20         30         40         50         60
MEELTIWEQH TATLSKDPRR GFGIAISGGR DRPGGSMVVS DVVPGGPAEG RLQTGDHIVM
        70         80         90        100        110        120
VNGVSMENAT SAFAIQILKT CTKMANITVK RPRRIHLPAT KASPSSPGRQ DSDEDDGPQR
       130        140        150        160        170        180
VEEVDQGRGY DGDSSSGSGR SWDERSRRPR PGRRGRAGSH GRRSPGGGSE ANGLALVSGF
       190        200        210        220        230        240
KRLPRQDVQM KPVKSVLVKR RDSEEFGVKL GSQIFIKHIT DSGLAARHRG LQEGDLILQI
       250        260        270        280        290        300
NGVSSQNLSL NDTRRLIEKS EGKLSLLVLR DRGQFLVNIP PAVSDSDSSP LEDISDLASE
       310        320        330        340        350        360
LSQAPPSHIP PPPRHAQRSP EASQTDSPVE SPRLRRESSV DSRTISEPDE QRSELPRESS
       370        380        390        400        410        420
YDIYRVPSSQ SMEDRGYSPD TRVVRFLKGK SIGLRLAGGN DVGIFVSGVQ AGSPADGQGI
       430        440        450        460        470        480
QEGDQILQVN DVPFQNLTRE EAVQFLLGLP PGEEMELVTQ RKQDIFWKMV QSRVGDSFYI
       490        500        510        520        530        540
RTHFELEPSP PSGLGFTRGD VFHVLDTLHP GPGQSHARGG HWLAVRMGRD LREQERGIIP
       550        560        570        580        590        600
NQSRAEQLAS LEAAQRAVGV GPGSSAGSNA RAEFWRLRGL RRGAKKTTQR SREDLSALTR
       610        620        630        640        650        660
QGRYPPYERV VLREASFKRP VVILGPVADI AMQKLTAEMP DQFEIAETVS RTDSPSKIIK
       670        680        690        700        710        720
LDTVRVIAEK DKHALLDVTP SAIERLNYVQ YYPIVVFFIP ESRPALKALR QWLAPASRRS
       730        740        750        760        770        780
TRRLYAQAQK LRKHSSHLFT ATIPLNGTSD TWYQELKAII REQQTRPIWT AEDQLDGSLE
       790        800        810        820        830        840
DNLDLPHHGL ADSSADLSCD SRVNSDYETD GEGGAYTDGE GYTDGEGGPY TDVDDEPPAP
       850        860        870        880        890        900
ALARSSEPVQ ADESQSPRDR GRISAHQGAQ VDSRHPQGQW RQDSMRTYER EALKKKFMRV
       910
HDAESSDEDG YDWGPATDL         10         20         30         40         50         60
MEELTIWEQH TATLSKDPRR GFGIAISGGR DRPGGSMVVS DVVPGGPAEG RLQTGDHIVM
        70         80         90        100        110        120
VNGVSMENAT SAFAIQILKT CTKMANITVK RPRRIHLPAT KASPSSPGRQ DSDEDDGPQR
       130        140        150        160        170        180
VEEVDQGRGY DGDSSSGSGR SWDERSRRPR PGRRGRAGSH GRRSPGGGSE ANGLALVSGF
       190        200        210        220        230        240
KRLPRQDVQM KPVKSVLVKR RDSEEFGVKL GSQIFIKHIT DSGLAARHRG LQEGDLILQI
       250        260        270        280        290        300
NGVSSQNLSL NDTRRLIEKS EGKLSLLVLR DRGQFLVNIP PAVSDSDSSP LEDISDLASE
       310        320        330        340        350        360
LSQAPPSHIP PPPRHAQRSP EASQTDSPVE SPRLRRESSV DSRTISEPDE QRSELPRESS
       370        380        390        400        410        420
YDIYRVPSSQ SMEDRGYSPD TRVVRFLKGK SIGLRLAGGN DVGIFVSGVQ AGSPADGQGI
       430        440        450        460        470        480
QEGDQILQVN DVPFQNLTRE EAVQFLLGLP PGEEMELVTQ RKQDIFWKMV QSRVGDSFYI
       490        500        510        520        530        540
RTHFELEPSP PSGLGFTRGD VFHVLDTLHP GPGQSHARGG HWLAVRMGRD LREQERGIIP
       550        560        570        580        590        600
NQSRAEQLAS LEAAQRAVGV GPGSSAGSNA RAEFWRLRGL RRGAKKTTQR SREDLSALTR
       610        620        630        640        650        660
QGRYPPYERV VLREASFKRP VVILGPVADI AMQKLTAEMP DQFEIAETVS RTDSPSKIIK
       670        680        690        700        710        720
LDTVRVIAEK DKHALLDVTP SAIERLNYVQ YYPIVVFFIP ESRPALKALR QWLAPASRRS
       730        740        750        760        770        780
TRRLYAQAQK LRKHSSHLFT ATIPLNGTSD TWYQELKAII REQQTRPIWT AEDQLDGSLE
       790        800        810        820        830        840
DNLDLPHHGL ADSSADLSCD SRVNSDYETD GEGGAYTDGE GYTDGEGGPY TDVDDEPPAP
       850        860        870        880        890        900
ALARSSEPVQ ADESQSPRDR GRISAHQGAQ VDSRHPQGQW RQDSMRTYER EALKKKFMRV
       910
HDAESSDEDG YDWGPATDL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O95049-1-unknown	MEELTI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O95049-1-unknown	MEELTI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101307
O95049-1-unknown	MEELTI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101308
O95049-37-unknown	MVVSDV...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt95660
O95049-37-unknown	MVVSDV...	37	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439991
O95049-37-unknown	MVVSDV...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105518
O95049-37-unknown	MVVSDV...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105519
O95049-559-unknown	GVGPGS...	559	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9919
O95049-559-unknown	GVGPGS...	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153654
O95049-559-unknown	GVGPGS...	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154202
O95049-559-unknown	GVGPGS...	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154308

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RQDSDE	113	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468641
...RQDSDE	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154514
...RQDSDE	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154515
...RQDSDE	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154516
...AQRAVG	558	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9919
...AQRAVG	558	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137078
...AQRAVG	558	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137622
...AQRAVG	558	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137728
...PATDL	919	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PATDL	919	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91278
...PATDL	919	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91277
...PATDL	919	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91276

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	558	RAVG.\|.GVGP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)