TopFIND 4.0

O95166: Gamma-aminobutyric acid receptor-associated protein

General Information

Protein names	- Gamma-aminobutyric acid receptor-associated protein - GABA(A) receptor-associated protein - MM46
Gene names	GABARAP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95166

3

N-termini

1

C-termini

2

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF
70 80 90 100 110
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95166-1-unknown	MKFVYK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95166-1-unknown	MKFVYK...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O95166-1-	MKFVYK...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O95166-91-unknown	MGQLYQ...	91		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460855
O95166-91-unknown	MGQLYQ...	91		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000461882
O95166-91-unknown	MGQLYQ...	91		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000459345

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...ESVYGL	116	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...ESVYGL	116	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC268
	...ESVYGL	116	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC272

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ATG4A_HUMAN	116	VYGL.\|.L	inferred from experiment	unknown	MEROPS	Yoshimori T	Kabeya Y et al.:LC3, GABARAP and GATE16 localiz... (C54.002)	15169837,
ATG4B_HUMAN	116	VYGL.\|.L	inferred from experiment	unknown	MEROPS	Kominami E	Tanida I et al.:HsAtg4B/HsApg4B/autophagin-1 cl... (C54.002)	15187094,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)