Q8WYN0: Cysteine protease ATG4A

General Information

Protein names	- Cysteine protease ATG4A - 3.4.22.- - AUT-like 2 cysteine endopeptidase - Autophagin-2 - Autophagy-related cysteine endopeptidase 2 - Autophagy-related protein 4 homolog A - hAPG4A
Gene names	ATG4A
Organism	Homo sapiens
Protease Family	C54.002
Protease ID	C54.002
Chromosome location
UniProt ID	Q8WYN0

2 N-termini

1 C-termini

0 Cleavages

4 Substrates

Sequence

Isoforms

- Isoform 2 of Cysteine protease ATG4A - Isoform 3 of Cysteine protease ATG4A - Isoform 4 of Cysteine protease ATG4A

Sequence View

        10         20         30         40         50         60
MESVLSKYED QITIFTDYLE EYPDTDELVW ILGKQHLLKT EKSKLLSDIS ARLWFTYRRK
        70         80         90        100        110        120
FSPIGGTGPS SDAGWGCMLR CGQMMLAQAL ICRHLGRDWS WEKQKEQPKE YQRILQCFLD
       130        140        150        160        170        180
RKDCCYSIHQ MAQMGVGEGK SIGEWFGPNT VAQVLKKLAL FDEWNSLAVY VSMDNTVVIE
       190        200        210        220        230        240
DIKKMCRVLP LSADTAGDRP PDSLTASNQS KGTSAYCSAW KPLLLIVPLR LGINQINPVY
       250        260        270        280        290        300
VDAFKECFKM PQSLGALGGK PNNAYYFIGF LGDELIFLDP HTTQTFVDTE ENGTVNDQTF
       310        320        330        340        350        360
HCLQSPQRMN ILNLDPSVAL GFFCKEEKDF DNWCSLVQKE ILKENLRMFE LVQKHPSHWP
       370        380        390
PFVPPAKPEV TTTGAEFIDS TEQLEEFDLE EDFEILSV         10         20         30         40         50         60
MESVLSKYED QITIFTDYLE EYPDTDELVW ILGKQHLLKT EKSKLLSDIS ARLWFTYRRK
        70         80         90        100        110        120
FSPIGGTGPS SDAGWGCMLR CGQMMLAQAL ICRHLGRDWS WEKQKEQPKE YQRILQCFLD
       130        140        150        160        170        180
RKDCCYSIHQ MAQMGVGEGK SIGEWFGPNT VAQVLKKLAL FDEWNSLAVY VSMDNTVVIE
       190        200        210        220        230        240
DIKKMCRVLP LSADTAGDRP PDSLTASNQS KGTSAYCSAW KPLLLIVPLR LGINQINPVY
       250        260        270        280        290        300
VDAFKECFKM PQSLGALGGK PNNAYYFIGF LGDELIFLDP HTTQTFVDTE ENGTVNDQTF
       310        320        330        340        350        360
HCLQSPQRMN ILNLDPSVAL GFFCKEEKDF DNWCSLVQKE ILKENLRMFE LVQKHPSHWP
       370        380        390
PFVPPAKPEV TTTGAEFIDS TEQLEEFDLE EDFEILSV         10         20         30         40         50         60
MESVLSKYED QITIFTDYLE EYPDTDELVW ILGKQHLLKT EKSKLLSDIS ARLWFTYRRK
        70         80         90        100        110        120
FSPIGGTGPS SDAGWGCMLR CGQMMLAQAL ICRHLGRDWS WEKQKEQPKE YQRILQCFLD
       130        140        150        160        170        180
RKDCCYSIHQ MAQMGVGEGK SIGEWFGPNT VAQVLKKLAL FDEWNSLAVY VSMDNTVVIE
       190        200        210        220        230        240
DIKKMCRVLP LSADTAGDRP PDSLTASNQS KGTSAYCSAW KPLLLIVPLR LGINQINPVY
       250        260        270        280        290        300
VDAFKECFKM PQSLGALGGK PNNAYYFIGF LGDELIFLDP HTTQTFVDTE ENGTVNDQTF
       310        320        330        340        350        360
HCLQSPQRMN ILNLDPSVAL GFFCKEEKDF DNWCSLVQKE ILKENLRMFE LVQKHPSHWP
       370        380        390
PFVPPAKPEV TTTGAEFIDS TEQLEEFDLE EDFEILSV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 4 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8WYN0-1-unknown	MESVLS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8WYN0-1-unknown	MESVLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67879
Q8WYN0-1-unknown	MESVLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67881
Q8WYN0-78-unknown	MLRCGQ...	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67880
Q8WYN0-78-unknown	MLRCGQ...	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt98124
Q8WYN0-78-unknown	MLRCGQ...	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt98125
Q8WYN0-78-unknown	MLRCGQ...	78	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8WYN0-78-unknown	MLRCGQ...	78	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EILSV	398	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EILSV	398	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63498
...EILSV	398	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63497
...EILSV	398	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63499

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GBRAP_HUMAN	116	VYGL.\|.L	inferred from experiment	unknown	MEROPS	Yoshimori T	Kabeya Y et al.:LC3, GABARAP and GATE16 localiz... (C54.002)	15169837,
GBRL2_HUMAN	116	TFGF.\|.F	inferred from experiment	unknown	MEROPS	Kominami E	Tanida I et al.:HsAtg4B/HsApg4B/autophagin-1 cl... (C54.002)	15187094,
GBRL1_HUMAN	116	VYGK.\|.K	inferred from experiment	unknown	MEROPS	Yin XM	Li M et al.:Kinetics comparisons of mammali... (C54.002)	21177865,
MLP3B_HUMAN	120	TFGM.\|.MKLS	inferred from experiment	unknown	MEROPS	Yin XM	Li M et al.:Kinetics comparisons of mammali... (C54.002)	21177865,