O95243: Methyl-CpG-binding domain protein 4

General Information

Protein names	- Methyl-CpG-binding domain protein 4 - 3.2.2.- - Methyl-CpG-binding endonuclease 1 - Methyl-CpG-binding protein MBD4 - Mismatch-specific DNA N-glycosylase
Gene names	MBD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95243

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Methyl-CpG-binding domain protein 4 - Isoform 3 of Methyl-CpG-binding domain protein 4 - Isoform 5 of Methyl-CpG-binding domain protein 4 - Isoform 4 of Methyl-CpG-binding domain protein 4

Sequence View

        10         20         30         40         50         60
MGTTGLESLS LGDRGAAPTV TSSERLVPDP PNDLRKEDVA MELERVGEDE EQMMIKRSSE
        70         80         90        100        110        120
CNPLLQEPIA SAQFGATAGT ECRKSVPCGW ERVVKQRLFG KTAGRFDVYF ISPQGLKFRS
       130        140        150        160        170        180
KSSLANYLHK NGETSLKPED FDFTVLSKRG IKSRYKDCSM AALTSHLQNQ SNNSNWNLRT
       190        200        210        220        230        240
RSKCKKDVFM PPSSSSELQE SRGLSNFTST HLLLKEDEGV DDVNFRKVRK PKGKVTILKG
       250        260        270        280        290        300
IPIKKTKKGC RKSCSGFVQS DSKRESVCNK ADAESEPVAQ KSQLDRTVCI SDAGACGETL
       310        320        330        340        350        360
SVTSEENSLV KKKERSLSSG SNFCSEQKTS GIINKFCSAK DSEHNEKYED TFLESEEIGT
       370        380        390        400        410        420
KVEVVERKEH LHTDILKRGS EMDNNCSPTR KDFTGEKIFQ EDTIPRTQIE RRKTSLYFSS
       430        440        450        460        470        480
KYNKEALSPP RRKAFKKWTP PRSPFNLVQE TLFHDPWKLL IATIFLNRTS GKMAIPVLWK
       490        500        510        520        530        540
FLEKYPSAEV ARTADWRDVS ELLKPLGLYD LRAKTIVKFS DEYLTKQWKY PIELHGIGKY
       550        560        570        580
GNDSYRIFCV NEWKQVHPED HKLNKYHDWL WENHEKLSLS         10         20         30         40         50         60
MGTTGLESLS LGDRGAAPTV TSSERLVPDP PNDLRKEDVA MELERVGEDE EQMMIKRSSE
        70         80         90        100        110        120
CNPLLQEPIA SAQFGATAGT ECRKSVPCGW ERVVKQRLFG KTAGRFDVYF ISPQGLKFRS
       130        140        150        160        170        180
KSSLANYLHK NGETSLKPED FDFTVLSKRG IKSRYKDCSM AALTSHLQNQ SNNSNWNLRT
       190        200        210        220        230        240
RSKCKKDVFM PPSSSSELQE SRGLSNFTST HLLLKEDEGV DDVNFRKVRK PKGKVTILKG
       250        260        270        280        290        300
IPIKKTKKGC RKSCSGFVQS DSKRESVCNK ADAESEPVAQ KSQLDRTVCI SDAGACGETL
       310        320        330        340        350        360
SVTSEENSLV KKKERSLSSG SNFCSEQKTS GIINKFCSAK DSEHNEKYED TFLESEEIGT
       370        380        390        400        410        420
KVEVVERKEH LHTDILKRGS EMDNNCSPTR KDFTGEKIFQ EDTIPRTQIE RRKTSLYFSS
       430        440        450        460        470        480
KYNKEALSPP RRKAFKKWTP PRSPFNLVQE TLFHDPWKLL IATIFLNRTS GKMAIPVLWK
       490        500        510        520        530        540
FLEKYPSAEV ARTADWRDVS ELLKPLGLYD LRAKTIVKFS DEYLTKQWKY PIELHGIGKY
       550        560        570        580
GNDSYRIFCV NEWKQVHPED HKLNKYHDWL WENHEKLSLS         10         20         30         40         50         60
MGTTGLESLS LGDRGAAPTV TSSERLVPDP PNDLRKEDVA MELERVGEDE EQMMIKRSSE
        70         80         90        100        110        120
CNPLLQEPIA SAQFGATAGT ECRKSVPCGW ERVVKQRLFG KTAGRFDVYF ISPQGLKFRS
       130        140        150        160        170        180
KSSLANYLHK NGETSLKPED FDFTVLSKRG IKSRYKDCSM AALTSHLQNQ SNNSNWNLRT
       190        200        210        220        230        240
RSKCKKDVFM PPSSSSELQE SRGLSNFTST HLLLKEDEGV DDVNFRKVRK PKGKVTILKG
       250        260        270        280        290        300
IPIKKTKKGC RKSCSGFVQS DSKRESVCNK ADAESEPVAQ KSQLDRTVCI SDAGACGETL
       310        320        330        340        350        360
SVTSEENSLV KKKERSLSSG SNFCSEQKTS GIINKFCSAK DSEHNEKYED TFLESEEIGT
       370        380        390        400        410        420
KVEVVERKEH LHTDILKRGS EMDNNCSPTR KDFTGEKIFQ EDTIPRTQIE RRKTSLYFSS
       430        440        450        460        470        480
KYNKEALSPP RRKAFKKWTP PRSPFNLVQE TLFHDPWKLL IATIFLNRTS GKMAIPVLWK
       490        500        510        520        530        540
FLEKYPSAEV ARTADWRDVS ELLKPLGLYD LRAKTIVKFS DEYLTKQWKY PIELHGIGKY
       550        560        570        580
GNDSYRIFCV NEWKQVHPED HKLNKYHDWL WENHEKLSLS         10         20         30         40         50         60
MGTTGLESLS LGDRGAAPTV TSSERLVPDP PNDLRKEDVA MELERVGEDE EQMMIKRSSE
        70         80         90        100        110        120
CNPLLQEPIA SAQFGATAGT ECRKSVPCGW ERVVKQRLFG KTAGRFDVYF ISPQGLKFRS
       130        140        150        160        170        180
KSSLANYLHK NGETSLKPED FDFTVLSKRG IKSRYKDCSM AALTSHLQNQ SNNSNWNLRT
       190        200        210        220        230        240
RSKCKKDVFM PPSSSSELQE SRGLSNFTST HLLLKEDEGV DDVNFRKVRK PKGKVTILKG
       250        260        270        280        290        300
IPIKKTKKGC RKSCSGFVQS DSKRESVCNK ADAESEPVAQ KSQLDRTVCI SDAGACGETL
       310        320        330        340        350        360
SVTSEENSLV KKKERSLSSG SNFCSEQKTS GIINKFCSAK DSEHNEKYED TFLESEEIGT
       370        380        390        400        410        420
KVEVVERKEH LHTDILKRGS EMDNNCSPTR KDFTGEKIFQ EDTIPRTQIE RRKTSLYFSS
       430        440        450        460        470        480
KYNKEALSPP RRKAFKKWTP PRSPFNLVQE TLFHDPWKLL IATIFLNRTS GKMAIPVLWK
       490        500        510        520        530        540
FLEKYPSAEV ARTADWRDVS ELLKPLGLYD LRAKTIVKFS DEYLTKQWKY PIELHGIGKY
       550        560        570        580
GNDSYRIFCV NEWKQVHPED HKLNKYHDWL WENHEKLSLS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95243-1-unknown	MGTTGL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95243-1-unknown	MGTTGL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80524
O95243-1-unknown	MGTTGL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80525
O95243-1-unknown	MGTTGL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80526
O95243-1-unknown	MGTTGL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80527
O95243-2-acetylation	GTTGLE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O95243-2-acetylation	GTTGLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162731
O95243-2-acetylation	GTTGLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162732
O95243-2-acetylation	GTTGLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162733
O95243-2-acetylation	GTTGLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162734
O95243-262-unknown	SKRESV...	262		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11014
O95243-262-unknown	SKRESV...	262		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148877
O95243-262-unknown	SKRESV...	262		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148878
O95243-262-unknown	SKRESV...	262		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148879

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FVQSDS	261	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11014
...FVQSDS	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132255
...FVQSDS	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132256
...FVQSDS	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132257
...KLSLS	580	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KLSLS	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76145
...KLSLS	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76142

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	261	QSDS.\|.SKRE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)