O95402: Mediator of RNA polymerase II transcription subunit 26

General Information

Protein names	- Mediator of RNA polymerase II transcription subunit 26 - Activator-recruited cofactor 70 kDa component - ARC70 - Cofactor required for Sp1 transcriptional activation subunit 7 - CRSP complex subunit 7 - Mediator complex subunit 26 - Transcriptional coactivator CRSP70
Gene names	MED26
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95402

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTAAPASPQQ IRDRLLQAID PQSNIRNMVA VLEVISSLEK YPITKEALEE TRLGKLINDV
        70         80         90        100        110        120
RKKTKNEELA KRAKKLLRSW QKLIEPAHQH EAALRGLAGA TGSANGGAHN CRPEVGAAGP
       130        140        150        160        170        180
PRSIHDLKSR NDLQRLPGQR LDRLGSRKRR GDQRDLGHPG PPPKVSKASH DPLVPNSSPL
       190        200        210        220        230        240
PTNGISGSPE SFASSLDGSG HAGPEGSRLE RDENDKHSGK IPVNAVRPHT SSPGLGKPPG
       250        260        270        280        290        300
PCLQPKASVL QQLDRVDETP GPPHPKGPPR CSFSPRNSRH EGSFARQQSL YAPKGSVPSP
       310        320        330        340        350        360
SPRPQALDAT QVPSPLPLAQ PSTPPVRRLE LLPSAESPVC WLEQPESHQR LAGPGCKAGL
       370        380        390        400        410        420
SPAEPLLSRA GFSPDSSKAD SDAASSGGSD SKKKKRYRPR DYTVNLDGQV AEAGVKPVRL
       430        440        450        460        470        480
KERKLTFDPM TRQIKPLTQK EPVRADSPVH MEQQSRTELD KQEAKASLQS PFEQTNWKEL
       490        500        510        520        530        540
SRNEIIQSYL SRQSSLLSSS GAQTPGAHHF MSEYLKQEES TRQGARQLHV LVPQSPPTDL
       550        560        570        580        590        600
PGLTREVTQD DLDRIQASQW PGVNGCQDTQ GNWYDWTQCI SLDPHGDDGR LNILPYVCLD

Isoforms

- Isoform 2 of Mediator of RNA polymerase II transcription subunit 26

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95402-1-unknown	MTAAPA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95402-1-unknown	MTAAPA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80789
O95402-2-acetylation	TAAPAS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O95402-2-acetylation	TAAPAS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O95402-2-acetylation	TAAPAS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162722
O95402-408-unknown	GQVAEA...	408			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O95402-408-	GQVAEA...	408			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O95402-408-	GQVAEA...	408			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O95402-408-	GQVAEA...	408			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...YVCLD	600	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)