O95758: Polypyrimidine tract-binding protein 3

General Information

Protein names	- Polypyrimidine tract-binding protein 3 - Regulator of differentiation 1 - Rod1
Gene names	PTBP3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95758

4 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Polypyrimidine tract-binding protein 3 - Isoform 2 of Polypyrimidine tract-binding protein 3 - Isoform 4 of Polypyrimidine tract-binding protein 3 - Isoform 5 of Polypyrimidine tract-binding protein 3 - Isoform 6 of Polypyrimidine tract-binding protein 3 - Isoform 7 of Polypyrimidine tract-binding protein 3

Sequence View

        10         20         30         40         50         60
MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTA NGNDSKKFKR DRPPCSPSRV
        70         80         90        100        110        120
LHLRKIPCDV TEAEIISLGL PFGKVTNLLM LKGKSQAFLE MASEEAAVTM VNYYTPITPH
       130        140        150        160        170        180
LRSQPVYIQY SNHRELKTDN LPNQARAQAA LQAVSAVQSG SLALSGGPSN EGTVLPGQSP
       190        200        210        220        230        240
VLRIIIENLF YPVTLEVLHQ IFSKFGTVLK IITFTKNNQF QALLQYADPV NAHYAKMALD
       250        260        270        280        290        300
GQNIYNACCT LRIDFSKLTS LNVKYNNDKS RDFTRLDLPT GDGQPSLEPP MAAAFGAPGI
       310        320        330        340        350        360
ISSPYAGAAG FAPAIGFPQA TGLSVPAVPG ALGPLTITSS AVTGRMAIPG ASGIPGNSVL
       370        380        390        400        410        420
LVTNLNPDLI TPHGLFILFG VYGDVHRVKI MFNKKENALV QMADANQAQL AMNHLSGQRL
       430        440        450        460        470        480
YGKVLRATLS KHQAVQLPRE GQEDQGLTKD FSNSPLHRFK KPGSKNFQNI FPPSATLHLS
       490        500        510        520        530        540
NIPPSVTVDD LKNLFIEAGC SVKAFKFFQK DRKMALIQLG SVEEAIQALI ELHNHDLGEN
       550
HHLRVSFSKS TI         10         20         30         40         50         60
MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTA NGNDSKKFKR DRPPCSPSRV
        70         80         90        100        110        120
LHLRKIPCDV TEAEIISLGL PFGKVTNLLM LKGKSQAFLE MASEEAAVTM VNYYTPITPH
       130        140        150        160        170        180
LRSQPVYIQY SNHRELKTDN LPNQARAQAA LQAVSAVQSG SLALSGGPSN EGTVLPGQSP
       190        200        210        220        230        240
VLRIIIENLF YPVTLEVLHQ IFSKFGTVLK IITFTKNNQF QALLQYADPV NAHYAKMALD
       250        260        270        280        290        300
GQNIYNACCT LRIDFSKLTS LNVKYNNDKS RDFTRLDLPT GDGQPSLEPP MAAAFGAPGI
       310        320        330        340        350        360
ISSPYAGAAG FAPAIGFPQA TGLSVPAVPG ALGPLTITSS AVTGRMAIPG ASGIPGNSVL
       370        380        390        400        410        420
LVTNLNPDLI TPHGLFILFG VYGDVHRVKI MFNKKENALV QMADANQAQL AMNHLSGQRL
       430        440        450        460        470        480
YGKVLRATLS KHQAVQLPRE GQEDQGLTKD FSNSPLHRFK KPGSKNFQNI FPPSATLHLS
       490        500        510        520        530        540
NIPPSVTVDD LKNLFIEAGC SVKAFKFFQK DRKMALIQLG SVEEAIQALI ELHNHDLGEN
       550
HHLRVSFSKS TI         10         20         30         40         50         60
MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTA NGNDSKKFKR DRPPCSPSRV
        70         80         90        100        110        120
LHLRKIPCDV TEAEIISLGL PFGKVTNLLM LKGKSQAFLE MASEEAAVTM VNYYTPITPH
       130        140        150        160        170        180
LRSQPVYIQY SNHRELKTDN LPNQARAQAA LQAVSAVQSG SLALSGGPSN EGTVLPGQSP
       190        200        210        220        230        240
VLRIIIENLF YPVTLEVLHQ IFSKFGTVLK IITFTKNNQF QALLQYADPV NAHYAKMALD
       250        260        270        280        290        300
GQNIYNACCT LRIDFSKLTS LNVKYNNDKS RDFTRLDLPT GDGQPSLEPP MAAAFGAPGI
       310        320        330        340        350        360
ISSPYAGAAG FAPAIGFPQA TGLSVPAVPG ALGPLTITSS AVTGRMAIPG ASGIPGNSVL
       370        380        390        400        410        420
LVTNLNPDLI TPHGLFILFG VYGDVHRVKI MFNKKENALV QMADANQAQL AMNHLSGQRL
       430        440        450        460        470        480
YGKVLRATLS KHQAVQLPRE GQEDQGLTKD FSNSPLHRFK KPGSKNFQNI FPPSATLHLS
       490        500        510        520        530        540
NIPPSVTVDD LKNLFIEAGC SVKAFKFFQK DRKMALIQLG SVEEAIQALI ELHNHDLGEN
       550
HHLRVSFSKS TI         10         20         30         40         50         60
MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTA NGNDSKKFKR DRPPCSPSRV
        70         80         90        100        110        120
LHLRKIPCDV TEAEIISLGL PFGKVTNLLM LKGKSQAFLE MASEEAAVTM VNYYTPITPH
       130        140        150        160        170        180
LRSQPVYIQY SNHRELKTDN LPNQARAQAA LQAVSAVQSG SLALSGGPSN EGTVLPGQSP
       190        200        210        220        230        240
VLRIIIENLF YPVTLEVLHQ IFSKFGTVLK IITFTKNNQF QALLQYADPV NAHYAKMALD
       250        260        270        280        290        300
GQNIYNACCT LRIDFSKLTS LNVKYNNDKS RDFTRLDLPT GDGQPSLEPP MAAAFGAPGI
       310        320        330        340        350        360
ISSPYAGAAG FAPAIGFPQA TGLSVPAVPG ALGPLTITSS AVTGRMAIPG ASGIPGNSVL
       370        380        390        400        410        420
LVTNLNPDLI TPHGLFILFG VYGDVHRVKI MFNKKENALV QMADANQAQL AMNHLSGQRL
       430        440        450        460        470        480
YGKVLRATLS KHQAVQLPRE GQEDQGLTKD FSNSPLHRFK KPGSKNFQNI FPPSATLHLS
       490        500        510        520        530        540
NIPPSVTVDD LKNLFIEAGC SVKAFKFFQK DRKMALIQLG SVEEAIQALI ELHNHDLGEN
       550
HHLRVSFSKS TI         10         20         30         40         50         60
MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTA NGNDSKKFKR DRPPCSPSRV
        70         80         90        100        110        120
LHLRKIPCDV TEAEIISLGL PFGKVTNLLM LKGKSQAFLE MASEEAAVTM VNYYTPITPH
       130        140        150        160        170        180
LRSQPVYIQY SNHRELKTDN LPNQARAQAA LQAVSAVQSG SLALSGGPSN EGTVLPGQSP
       190        200        210        220        230        240
VLRIIIENLF YPVTLEVLHQ IFSKFGTVLK IITFTKNNQF QALLQYADPV NAHYAKMALD
       250        260        270        280        290        300
GQNIYNACCT LRIDFSKLTS LNVKYNNDKS RDFTRLDLPT GDGQPSLEPP MAAAFGAPGI
       310        320        330        340        350        360
ISSPYAGAAG FAPAIGFPQA TGLSVPAVPG ALGPLTITSS AVTGRMAIPG ASGIPGNSVL
       370        380        390        400        410        420
LVTNLNPDLI TPHGLFILFG VYGDVHRVKI MFNKKENALV QMADANQAQL AMNHLSGQRL
       430        440        450        460        470        480
YGKVLRATLS KHQAVQLPRE GQEDQGLTKD FSNSPLHRFK KPGSKNFQNI FPPSATLHLS
       490        500        510        520        530        540
NIPPSVTVDD LKNLFIEAGC SVKAFKFFQK DRKMALIQLG SVEEAIQALI ELHNHDLGEN
       550
HHLRVSFSKS TI         10         20         30         40         50         60
MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTA NGNDSKKFKR DRPPCSPSRV
        70         80         90        100        110        120
LHLRKIPCDV TEAEIISLGL PFGKVTNLLM LKGKSQAFLE MASEEAAVTM VNYYTPITPH
       130        140        150        160        170        180
LRSQPVYIQY SNHRELKTDN LPNQARAQAA LQAVSAVQSG SLALSGGPSN EGTVLPGQSP
       190        200        210        220        230        240
VLRIIIENLF YPVTLEVLHQ IFSKFGTVLK IITFTKNNQF QALLQYADPV NAHYAKMALD
       250        260        270        280        290        300
GQNIYNACCT LRIDFSKLTS LNVKYNNDKS RDFTRLDLPT GDGQPSLEPP MAAAFGAPGI
       310        320        330        340        350        360
ISSPYAGAAG FAPAIGFPQA TGLSVPAVPG ALGPLTITSS AVTGRMAIPG ASGIPGNSVL
       370        380        390        400        410        420
LVTNLNPDLI TPHGLFILFG VYGDVHRVKI MFNKKENALV QMADANQAQL AMNHLSGQRL
       430        440        450        460        470        480
YGKVLRATLS KHQAVQLPRE GQEDQGLTKD FSNSPLHRFK KPGSKNFQNI FPPSATLHLS
       490        500        510        520        530        540
NIPPSVTVDD LKNLFIEAGC SVKAFKFFQK DRKMALIQLG SVEEAIQALI ELHNHDLGEN
       550
HHLRVSFSKS TI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O95758-1-unknown	MDGVVT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O95758-1-unknown	MDGVVT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86442
O95758-165-unknown	SGGPSN...	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13881
O95758-165-unknown	SGGPSN...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140630
O95758-165-unknown	SGGPSN...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144168
O95758-165-unknown	SGGPSN...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144169
O95758-165-unknown	SGGPSN...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145440
O95758-165-unknown	SGGPSN...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145555
O95758-324-unknown	SVPAVP...	324	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13888
O95758-324-unknown	SVPAVP...	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147687
O95758-324-unknown	SVPAVP...	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149765
O95758-324-unknown	SVPAVP...	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149766
O95758-324-unknown	SVPAVP...	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150464
O95758-324-unknown	SVPAVP...	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150526
O95758-336-unknown	TITSSA...	336	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13895
O95758-336-unknown	TITSSA...	336	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148137
O95758-336-unknown	TITSSA...	336	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150074
O95758-336-unknown	TITSSA...	336	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150075
O95758-336-unknown	TITSSA...	336	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150702
O95758-336-unknown	TITSSA...	336	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150777

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...GSLALS	164	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13881
...GSLALS	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123764
...GSLALS	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127421
...GSLALS	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127422
...GSLALS	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128734
...GSLALS	164	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128853
...QATGLS	323	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13888
...QATGLS	323	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt131040
...QATGLS	323	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133154
...QATGLS	323	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133155
...QATGLS	323	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133859
...QATGLS	323	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133922
...ALGPLT	335	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13895
...ALGPLT	335	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt131504
...ALGPLT	335	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133466
...ALGPLT	335	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133467
...ALGPLT	335	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134100
...ALGPLT	335	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134179
...SKSTI	552	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SKSTI	552	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82062
...SKSTI	552	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82061
...SKSTI	552	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82060
...SKSTI	552	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt82059
...SKSTI	552		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SKSTI	552		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SKSTI	552		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SKSTI	552		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	164	LALS.\|.SGGP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	323	TGLS.\|.SVPA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	335	GPLT.\|.TITS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)