O96005: Cleft lip and palate transmembrane protein 1

General Information

Protein names	- Cleft lip and palate transmembrane protein 1
Gene names	CLPTM1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O96005

7 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cleft lip and palate transmembrane protein 1 - Isoform 3 of Cleft lip and palate transmembrane protein 1

Sequence View

        10         20         30         40         50         60
MAAAQEADGA RSAVVAAGGG SSGQVTSNGS IGRDPPAETQ PQNPPAQPAP NAWQVIKGVL
        70         80         90        100        110        120
FRIFIIWAIS SWFRRGPAPQ DQAGPGGAPR VASRNLFPKD TLMNLHVYIS EHEHFTDFNA
       130        140        150        160        170        180
TSALFWEQHD LVYGDWTSGE NSDGCYEHFA ELDIPQSVQQ NGSIYIHVYF TKSGFHPDPR
       190        200        210        220        230        240
QKALYRRLAT VHMSRMINKY KRRRFQKTKN LLTGETEADP EMIKRAEDYG PVEVISHWHP
       250        260        270        280        290        300
NITINIVDDH TPWVKGSVPP PLDQYVKFDA VSGDYYPIIY FNDYWNLQKD YYPINESLAS
       310        320        330        340        350        360
LPLRVSFCPL SLWRWQLYAA QSTKSPWNFL GDELYEQSDE EQDSVKVALL ETNPYLLALT
       370        380        390        400        410        420
IIVSIVHSVF EFLAFKNDIQ FWNSRQSLEG LSVRSVFFGV FQSFVVLLYI LDNETNFVVQ
       430        440        450        460        470        480
VSVFIGVLID LWKITKVMDV RLDREHRVAG IFPRLSFKDK STYIESSTKV YDDMAFRYLS
       490        500        510        520        530        540
WILFPLLGCY AVYSLLYLEH KGWYSWVLSM LYGFLLTFGF ITMTPQLFIN YKLKSVAHLP
       550        560        570        580        590        600
WRMLTYKALN TFIDDLFAFV IKMPVMYRIG CLRDDVVFFI YLYQRWIYRV DPTRVNEFGM
       610        620        630        640        650        660
SGEDPTAAAP VAEVPTAAGA LTPTPAPTTT TATREEASTS LPTKPTQGAS SASEPQEAPP

KPAEDKKKD         10         20         30         40         50         60
MAAAQEADGA RSAVVAAGGG SSGQVTSNGS IGRDPPAETQ PQNPPAQPAP NAWQVIKGVL
        70         80         90        100        110        120
FRIFIIWAIS SWFRRGPAPQ DQAGPGGAPR VASRNLFPKD TLMNLHVYIS EHEHFTDFNA
       130        140        150        160        170        180
TSALFWEQHD LVYGDWTSGE NSDGCYEHFA ELDIPQSVQQ NGSIYIHVYF TKSGFHPDPR
       190        200        210        220        230        240
QKALYRRLAT VHMSRMINKY KRRRFQKTKN LLTGETEADP EMIKRAEDYG PVEVISHWHP
       250        260        270        280        290        300
NITINIVDDH TPWVKGSVPP PLDQYVKFDA VSGDYYPIIY FNDYWNLQKD YYPINESLAS
       310        320        330        340        350        360
LPLRVSFCPL SLWRWQLYAA QSTKSPWNFL GDELYEQSDE EQDSVKVALL ETNPYLLALT
       370        380        390        400        410        420
IIVSIVHSVF EFLAFKNDIQ FWNSRQSLEG LSVRSVFFGV FQSFVVLLYI LDNETNFVVQ
       430        440        450        460        470        480
VSVFIGVLID LWKITKVMDV RLDREHRVAG IFPRLSFKDK STYIESSTKV YDDMAFRYLS
       490        500        510        520        530        540
WILFPLLGCY AVYSLLYLEH KGWYSWVLSM LYGFLLTFGF ITMTPQLFIN YKLKSVAHLP
       550        560        570        580        590        600
WRMLTYKALN TFIDDLFAFV IKMPVMYRIG CLRDDVVFFI YLYQRWIYRV DPTRVNEFGM
       610        620        630        640        650        660
SGEDPTAAAP VAEVPTAAGA LTPTPAPTTT TATREEASTS LPTKPTQGAS SASEPQEAPP

KPAEDKKKD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O96005-2-unknown	MAAAQE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O96005-2-unknown	MAAAQE...	1			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O96005-2-unknown	MAAAQE...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O96005-2-	AAAQEA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O96005-2-	AAAQEA...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
O96005-2-	AAAQEA...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O96005-2-	AAAQEA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O96005-2-Acetylation	AAAQEA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O96005-2-Acetylation	AAAQEA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O96005-2-Acetylation	AAAQEA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O96005-103-unknown	MNLHVY...	103		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443192
O96005-531-unknown	YKLKSV...	531		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000468310
O96005-638-	STSLPT...	638			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O96005-640-	SLPTKP...	640			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PEMIKR	224	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467927
	...DKKKD	669	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)