O96013: Serine/threonine-protein kinase PAK 4

General Information

Protein names	- Serine/threonine-protein kinase PAK 4 - 2.7.11.1 - p21-activated kinase 4 - PAK-4
Gene names	PAK4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O96013

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein kinase PAK 4 - Isoform 3 of Serine/threonine-protein kinase PAK 4 - Isoform 4 of Serine/threonine-protein kinase PAK 4

Sequence View

        10         20         30         40         50         60
MFGKRKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP KPLVDPACIT
        70         80         90        100        110        120
SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL RRDSPPPPAR ARQENGMPEE
       130        140        150        160        170        180
PATTARGGPG KAGSRGRFAG HSEAGGGSGD RRRAGPEKRP KSSREGSGGP QESSRDKRPL
       190        200        210        220        230        240
SGPDVGTPQP AGLASGAKLA AGRPFNTYPR ADTDHPSRGA QGEPHDVAPN GPSAGGLAIP
       250        260        270        280        290        300
QSSSSSSRPP TRARGAPSPG VLGPHASEPQ LAPPACTPAA PAVPGPPGPR SPQREPQRVS
       310        320        330        340        350        360
HEQFRAALQL VVDPGDPRSY LDNFIKIGEG STGIVCIATV RSSGKLVAVK KMDLRKQQRR
       370        380        390        400        410        420
ELLFNEVVIM RDYQHENVVE MYNSYLVGDE LWVVMEFLEG GALTDIVTHT RMNEEQIAAV
       430        440        450        460        470        480
CLAVLQALSV LHAQGVIHRD IKSDSILLTH DGRVKLSDFG FCAQVSKEVP RRKSLVGTPY
       490        500        510        520        530        540
WMAPELISRL PYGPEVDIWS LGIMVIEMVD GEPPYFNEPP LKAMKMIRDN LPPRLKNLHK
       550        560        570        580        590
VSPSLKGFLD RLLVRDPAQR ATAAELLKHP FLAKAGPPAS IVPLMRQNRT R         10         20         30         40         50         60
MFGKRKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP KPLVDPACIT
        70         80         90        100        110        120
SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL RRDSPPPPAR ARQENGMPEE
       130        140        150        160        170        180
PATTARGGPG KAGSRGRFAG HSEAGGGSGD RRRAGPEKRP KSSREGSGGP QESSRDKRPL
       190        200        210        220        230        240
SGPDVGTPQP AGLASGAKLA AGRPFNTYPR ADTDHPSRGA QGEPHDVAPN GPSAGGLAIP
       250        260        270        280        290        300
QSSSSSSRPP TRARGAPSPG VLGPHASEPQ LAPPACTPAA PAVPGPPGPR SPQREPQRVS
       310        320        330        340        350        360
HEQFRAALQL VVDPGDPRSY LDNFIKIGEG STGIVCIATV RSSGKLVAVK KMDLRKQQRR
       370        380        390        400        410        420
ELLFNEVVIM RDYQHENVVE MYNSYLVGDE LWVVMEFLEG GALTDIVTHT RMNEEQIAAV
       430        440        450        460        470        480
CLAVLQALSV LHAQGVIHRD IKSDSILLTH DGRVKLSDFG FCAQVSKEVP RRKSLVGTPY
       490        500        510        520        530        540
WMAPELISRL PYGPEVDIWS LGIMVIEMVD GEPPYFNEPP LKAMKMIRDN LPPRLKNLHK
       550        560        570        580        590
VSPSLKGFLD RLLVRDPAQR ATAAELLKHP FLAKAGPPAS IVPLMRQNRT R         10         20         30         40         50         60
MFGKRKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP KPLVDPACIT
        70         80         90        100        110        120
SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL RRDSPPPPAR ARQENGMPEE
       130        140        150        160        170        180
PATTARGGPG KAGSRGRFAG HSEAGGGSGD RRRAGPEKRP KSSREGSGGP QESSRDKRPL
       190        200        210        220        230        240
SGPDVGTPQP AGLASGAKLA AGRPFNTYPR ADTDHPSRGA QGEPHDVAPN GPSAGGLAIP
       250        260        270        280        290        300
QSSSSSSRPP TRARGAPSPG VLGPHASEPQ LAPPACTPAA PAVPGPPGPR SPQREPQRVS
       310        320        330        340        350        360
HEQFRAALQL VVDPGDPRSY LDNFIKIGEG STGIVCIATV RSSGKLVAVK KMDLRKQQRR
       370        380        390        400        410        420
ELLFNEVVIM RDYQHENVVE MYNSYLVGDE LWVVMEFLEG GALTDIVTHT RMNEEQIAAV
       430        440        450        460        470        480
CLAVLQALSV LHAQGVIHRD IKSDSILLTH DGRVKLSDFG FCAQVSKEVP RRKSLVGTPY
       490        500        510        520        530        540
WMAPELISRL PYGPEVDIWS LGIMVIEMVD GEPPYFNEPP LKAMKMIRDN LPPRLKNLHK
       550        560        570        580        590
VSPSLKGFLD RLLVRDPAQR ATAAELLKHP FLAKAGPPAS IVPLMRQNRT R

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O96013-1-unknown	MFGKRK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O96013-1-unknown	MFGKRK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84178
O96013-1-unknown	MFGKRK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84179
O96013-1-unknown	MFGKRK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84180
O96013-113-unknown	QENGMP...	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9927

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PARARQ	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9927
...PARARQ	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126358
...PARARQ	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154498
...QNRTR	591	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QNRTR	591	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79796
...QNRTR	591	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79797
...QNRTR	591	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79798

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	112	RARQ.\|.QENG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)