P00352: Retinal dehydrogenase 1 {ECO:0000305}

General Information

Protein names	- Retinal dehydrogenase 1 {ECO:0000305} - RALDH 1 {ECO:0000305} - RalDH1 {ECO:0000305} - 1.2.1.- {ECO:0000269\|PubMed:19296407, ECO:0000269\|PubMed:25450233, ECO:0000269\|PubMed:26373694} - 1.2.1.36 {ECO:0000250\|UniProtKB:P51647} - ALDH-E1 - ALHDII - Aldehyde dehydrogenase family 1 member A1 {ECO:0000312\|HGNC:HGNC:402} - Aldehyde dehydrogenase, cytosolic {ECO:0000303\|PubMed:2591967}
Gene names	ALDH1A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00352

3 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSSGTPDLP VLLTDLKIQY TKIFINNEWH DSVSGKKFPV FNPATEEELC QVEEGDKEDV
        70         80         90        100        110        120
DKAVKAARQA FQIGSPWRTM DASERGRLLY KLADLIERDR LLLATMESMN GGKLYSNAYL
       130        140        150        160        170        180
NDLAGCIKTL RYCAGWADKI QGRTIPIDGN FFTYTRHEPI GVCGQIIPWN FPLVMLIWKI
       190        200        210        220        230        240
GPALSCGNTV VVKPAEQTPL TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDID
       250        260        270        280        290        300
KVAFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVLA DADLDNAVEF AHHGVFYHQG
       310        320        330        340        350        360
QCCIAASRIF VEESIYDEFV RRSVERAKKY ILGNPLTPGV TQGPQIDKEQ YDKILDLIES
       370        380        390        400        410        420
GKKEGAKLEC GGGPWGNKGY FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSLDDVIKR
       430        440        450        460        470        480
ANNTFYGLSA GVFTKDIDKA ITISSALQAG TVWVNCYGVV SAQCPFGGFK MSGNGRELGE
       490        500
YGFHEYTEVK TVTVKISQKN S

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P00352-2-unknown	MSSSGT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00352-2-Acetylation	SSSGTP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00352-2-Acetylation	SSSGTP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P00352-2-Acetylation	SSSGTP...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P00352-309-acetylation	IFVEES...	309	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PLTALH	203	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401361
...SSHMDI	238	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388026
...SQKNS	501	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)