P00390: Glutathione reductase, mitochondrial

General Information

Protein names	- Glutathione reductase, mitochondrial - GR - GRase - 1.8.1.7
Gene names	GSR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00390

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Cytoplasmic of Glutathione reductase, mitochondrial - Isoform 2 of Glutathione reductase, mitochondrial - Isoform 3 of Glutathione reductase, mitochondrial - Isoform 4 of Glutathione reductase, mitochondrial

Sequence View

        10         20         30         40         50         60
MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL SRAMACRQEP QPQGPPPAAG
        70         80         90        100        110        120
AVASYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG TCVNVGCVPK KVMWNTAVHS
       130        140        150        160        170        180
EFMHDHADYG FPSCEGKFNW RVIKEKRDAY VSRLNAIYQN NLTKSHIEII RGHAAFTSDP
       190        200        210        220        230        240
KPTIEVSGKK YTAPHILIAT GGMPSTPHES QIPGASLGIT SDGFFQLEEL PGRSVIVGAG
       250        260        270        280        290        300
YIAVEMAGIL SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK
       310        320        330        340        350        360
TLSGLEVSMV TAVPGRLPVM TMIPDVDCLL WAIGRVPNTK DLSLNKLGIQ TDDKGHIIVD
       370        380        390        400        410        420
EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEY KEDSKLDYNN IPTVVFSHPP
       430        440        450        460        470        480
IGTVGLTEDE AIHKYGIENV KTYSTSFTPM YHAVTKRKTK CVMKMVCANK EEKVVGIHMQ
       490        500        510        520
GLGCDEMLQG FAVAVKMGAT KADFDNTVAI HPTSSEELVT LR         10         20         30         40         50         60
MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL SRAMACRQEP QPQGPPPAAG
        70         80         90        100        110        120
AVASYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG TCVNVGCVPK KVMWNTAVHS
       130        140        150        160        170        180
EFMHDHADYG FPSCEGKFNW RVIKEKRDAY VSRLNAIYQN NLTKSHIEII RGHAAFTSDP
       190        200        210        220        230        240
KPTIEVSGKK YTAPHILIAT GGMPSTPHES QIPGASLGIT SDGFFQLEEL PGRSVIVGAG
       250        260        270        280        290        300
YIAVEMAGIL SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK
       310        320        330        340        350        360
TLSGLEVSMV TAVPGRLPVM TMIPDVDCLL WAIGRVPNTK DLSLNKLGIQ TDDKGHIIVD
       370        380        390        400        410        420
EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEY KEDSKLDYNN IPTVVFSHPP
       430        440        450        460        470        480
IGTVGLTEDE AIHKYGIENV KTYSTSFTPM YHAVTKRKTK CVMKMVCANK EEKVVGIHMQ
       490        500        510        520
GLGCDEMLQG FAVAVKMGAT KADFDNTVAI HPTSSEELVT LR         10         20         30         40         50         60
MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL SRAMACRQEP QPQGPPPAAG
        70         80         90        100        110        120
AVASYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG TCVNVGCVPK KVMWNTAVHS
       130        140        150        160        170        180
EFMHDHADYG FPSCEGKFNW RVIKEKRDAY VSRLNAIYQN NLTKSHIEII RGHAAFTSDP
       190        200        210        220        230        240
KPTIEVSGKK YTAPHILIAT GGMPSTPHES QIPGASLGIT SDGFFQLEEL PGRSVIVGAG
       250        260        270        280        290        300
YIAVEMAGIL SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK
       310        320        330        340        350        360
TLSGLEVSMV TAVPGRLPVM TMIPDVDCLL WAIGRVPNTK DLSLNKLGIQ TDDKGHIIVD
       370        380        390        400        410        420
EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEY KEDSKLDYNN IPTVVFSHPP
       430        440        450        460        470        480
IGTVGLTEDE AIHKYGIENV KTYSTSFTPM YHAVTKRKTK CVMKMVCANK EEKVVGIHMQ
       490        500        510        520
GLGCDEMLQG FAVAVKMGAT KADFDNTVAI HPTSSEELVT LR         10         20         30         40         50         60
MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL SRAMACRQEP QPQGPPPAAG
        70         80         90        100        110        120
AVASYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG TCVNVGCVPK KVMWNTAVHS
       130        140        150        160        170        180
EFMHDHADYG FPSCEGKFNW RVIKEKRDAY VSRLNAIYQN NLTKSHIEII RGHAAFTSDP
       190        200        210        220        230        240
KPTIEVSGKK YTAPHILIAT GGMPSTPHES QIPGASLGIT SDGFFQLEEL PGRSVIVGAG
       250        260        270        280        290        300
YIAVEMAGIL SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK
       310        320        330        340        350        360
TLSGLEVSMV TAVPGRLPVM TMIPDVDCLL WAIGRVPNTK DLSLNKLGIQ TDDKGHIIVD
       370        380        390        400        410        420
EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEY KEDSKLDYNN IPTVVFSHPP
       430        440        450        460        470        480
IGTVGLTEDE AIHKYGIENV KTYSTSFTPM YHAVTKRKTK CVMKMVCANK EEKVVGIHMQ
       490        500        510        520
GLGCDEMLQG FAVAVKMGAT KADFDNTVAI HPTSSEELVT LR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P00390-1-unknown	MALLPR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76576
P00390-1-unknown	MALLPR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76577
P00390-1-unknown	MALLPR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76578
P00390-27-unknown	LLLLPE...	27	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P00390-27-unknown	LLLLPE...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195457
P00390-27-unknown	LLLLPE...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195458
P00390-27-unknown	LLLLPE...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195459
P00390-44-unknown	MACRQE...	44	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00390-44-unknown	MACRQE...	44	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76575
P00390-44-unknown	MACRQE...	44	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97669
P00390-44-unknown	MACRQE...	44	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97670
P00390-44-unknown	MACRQE...	44	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97671
P00390-423-unknown	TVGLTE...	423	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3303
P00390-423-unknown	TVGLTE...	423	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150769
P00390-423-unknown	TVGLTE...	423	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151423
P00390-423-unknown	TVGLTE...	423	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151628
P00390-423-unknown	TVGLTE...	423	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151912

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HPPIGT	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3303
...HPPIGT	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134169
...HPPIGT	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134826
...HPPIGT	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135032
...HPPIGT	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135320
...LVTLR	522	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LVTLR	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72196
...LVTLR	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72195
...LVTLR	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72193
...LVTLR	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72194

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	422	PIGT.\|.TVGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)