P00520: Tyrosine-protein kinase ABL1

General Information

Protein names	- Tyrosine-protein kinase ABL1 - 2.7.10.2 {ECO:0000269\|PubMed:10988075, ECO:0000269\|PubMed:12748290, ECO:0000269\|PubMed:19878872, ECO:0000269\|PubMed:20072125} - Abelson murine leukemia viral oncogene homolog 1 - Abelson tyrosine-protein kinase 1 - Proto-oncogene c-Abl - p150
Gene names	Abl1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P00520

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform II of Tyrosine-protein kinase ABL1 - Isoform III of Tyrosine-protein kinase ABL1 - Isoform IV of Tyrosine-protein kinase ABL1

Sequence View

        10         20         30         40         50         60
MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE
        70         80         90        100        110        120
NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN
       130        140        150        160        170        180
SLEKHSWYHG PVSRNAAEYL LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS
       190        200        210        220        230        240
DGKLYVSSES RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTIYGVSP NYDKWEMERT
       250        260        270        280        290        300
DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ
       310        320        330        340        350        360
LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVSAVVL LYMATQISSA MEYLEKKNFI
       370        380        390        400        410        420
HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK FPIKWTAPES LAYNKFSIKS
       430        440        450        460        470        480
DVWAFGVLLW EIATYGMSPY PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP
       490        500        510        520        530        540
SDRPSFAEIH QAFETMFQES SISDEVEKEL GKRGTRGGAG SMLQAPELPT KTRTCRRAAE
       550        560        570        580        590        600
QKDAPDTPEL LHTKGLGESD ALDSEPAVSP LLPRKERGPP DGSLNEDERL LPRDRKTNLF
       610        620        630        640        650        660
SALIKKKKKM APTPPKRSSS FREMDGQPDR RGASEDDSRE LCNGPPALTS DAAEPTKSPK
       670        680        690        700        710        720
ASNGAGVPNG AFREPGNSGF RSPHMWKKSS TLTGSRLAAA EEESGMSSSK RFLRSCSASC
       730        740        750        760        770        780
MPHGARDTEW RSVTLPRDLP SAGKQFDSST FGGHKSEKPA LPRKRTSESR SEQVAKSTAM
       790        800        810        820        830        840
PPPRLVKKNE EAAEEGFKDT ESSPGSSPPS LTPKLLRRQV TASPSSGLSH KEEATKGSAS
       850        860        870        880        890        900
GMGTPATAEP APPSNKVGLS KASSEEMRVR RHKHSSESPG RDKGRLAKLK PAPPPPPACT
       910        920        930        940        950        960
GKAGKPAQSP SQEAGEAGGP TKTKCTSLAM DAVNTDPTKA GPPGEGLRKP VPPSVPKPQS
       970        980        990       1000       1010       1020
TAKPPGTPTS PVSTPSTAPA PSPLAGDQQP SSAAFIPLIS TRVSLRKTRQ PPERIASGTI
      1030       1040       1050       1060       1070       1080
TKGVVLDSTE ALCLAISRNS EQMASHSAVL EAGKNLYTFC VSYVDSIQQM RNKFAFREAI
      1090       1100       1110       1120
NKLESNLREL QICPATASSG PAATQDFSKL LSSVKEISDI VRR         10         20         30         40         50         60
MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE
        70         80         90        100        110        120
NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN
       130        140        150        160        170        180
SLEKHSWYHG PVSRNAAEYL LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS
       190        200        210        220        230        240
DGKLYVSSES RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTIYGVSP NYDKWEMERT
       250        260        270        280        290        300
DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ
       310        320        330        340        350        360
LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVSAVVL LYMATQISSA MEYLEKKNFI
       370        380        390        400        410        420
HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK FPIKWTAPES LAYNKFSIKS
       430        440        450        460        470        480
DVWAFGVLLW EIATYGMSPY PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP
       490        500        510        520        530        540
SDRPSFAEIH QAFETMFQES SISDEVEKEL GKRGTRGGAG SMLQAPELPT KTRTCRRAAE
       550        560        570        580        590        600
QKDAPDTPEL LHTKGLGESD ALDSEPAVSP LLPRKERGPP DGSLNEDERL LPRDRKTNLF
       610        620        630        640        650        660
SALIKKKKKM APTPPKRSSS FREMDGQPDR RGASEDDSRE LCNGPPALTS DAAEPTKSPK
       670        680        690        700        710        720
ASNGAGVPNG AFREPGNSGF RSPHMWKKSS TLTGSRLAAA EEESGMSSSK RFLRSCSASC
       730        740        750        760        770        780
MPHGARDTEW RSVTLPRDLP SAGKQFDSST FGGHKSEKPA LPRKRTSESR SEQVAKSTAM
       790        800        810        820        830        840
PPPRLVKKNE EAAEEGFKDT ESSPGSSPPS LTPKLLRRQV TASPSSGLSH KEEATKGSAS
       850        860        870        880        890        900
GMGTPATAEP APPSNKVGLS KASSEEMRVR RHKHSSESPG RDKGRLAKLK PAPPPPPACT
       910        920        930        940        950        960
GKAGKPAQSP SQEAGEAGGP TKTKCTSLAM DAVNTDPTKA GPPGEGLRKP VPPSVPKPQS
       970        980        990       1000       1010       1020
TAKPPGTPTS PVSTPSTAPA PSPLAGDQQP SSAAFIPLIS TRVSLRKTRQ PPERIASGTI
      1030       1040       1050       1060       1070       1080
TKGVVLDSTE ALCLAISRNS EQMASHSAVL EAGKNLYTFC VSYVDSIQQM RNKFAFREAI
      1090       1100       1110       1120
NKLESNLREL QICPATASSG PAATQDFSKL LSSVKEISDI VRR         10         20         30         40         50         60
MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE
        70         80         90        100        110        120
NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN
       130        140        150        160        170        180
SLEKHSWYHG PVSRNAAEYL LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS
       190        200        210        220        230        240
DGKLYVSSES RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTIYGVSP NYDKWEMERT
       250        260        270        280        290        300
DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ
       310        320        330        340        350        360
LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVSAVVL LYMATQISSA MEYLEKKNFI
       370        380        390        400        410        420
HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK FPIKWTAPES LAYNKFSIKS
       430        440        450        460        470        480
DVWAFGVLLW EIATYGMSPY PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP
       490        500        510        520        530        540
SDRPSFAEIH QAFETMFQES SISDEVEKEL GKRGTRGGAG SMLQAPELPT KTRTCRRAAE
       550        560        570        580        590        600
QKDAPDTPEL LHTKGLGESD ALDSEPAVSP LLPRKERGPP DGSLNEDERL LPRDRKTNLF
       610        620        630        640        650        660
SALIKKKKKM APTPPKRSSS FREMDGQPDR RGASEDDSRE LCNGPPALTS DAAEPTKSPK
       670        680        690        700        710        720
ASNGAGVPNG AFREPGNSGF RSPHMWKKSS TLTGSRLAAA EEESGMSSSK RFLRSCSASC
       730        740        750        760        770        780
MPHGARDTEW RSVTLPRDLP SAGKQFDSST FGGHKSEKPA LPRKRTSESR SEQVAKSTAM
       790        800        810        820        830        840
PPPRLVKKNE EAAEEGFKDT ESSPGSSPPS LTPKLLRRQV TASPSSGLSH KEEATKGSAS
       850        860        870        880        890        900
GMGTPATAEP APPSNKVGLS KASSEEMRVR RHKHSSESPG RDKGRLAKLK PAPPPPPACT
       910        920        930        940        950        960
GKAGKPAQSP SQEAGEAGGP TKTKCTSLAM DAVNTDPTKA GPPGEGLRKP VPPSVPKPQS
       970        980        990       1000       1010       1020
TAKPPGTPTS PVSTPSTAPA PSPLAGDQQP SSAAFIPLIS TRVSLRKTRQ PPERIASGTI
      1030       1040       1050       1060       1070       1080
TKGVVLDSTE ALCLAISRNS EQMASHSAVL EAGKNLYTFC VSYVDSIQQM RNKFAFREAI
      1090       1100       1110       1120
NKLESNLREL QICPATASSG PAATQDFSKL LSSVKEISDI VRR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P00520-1-unknown	MLEICL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00520-3-unknown	EICLKL...	3	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P00520-37-unknown	FEPQGL...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32296
P00520-37-unknown	FEPQGL...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195813
P00520-37-unknown	FEPQGL...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195812
P00520-37-unknown	FEPQGL...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195811
P00520-165-unknown	LRYEGR...	165	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P00520-165-unknown	LRYEGR...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197770
P00520-165-unknown	LRYEGR...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197769
P00520-165-unknown	LRYEGR...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197768
P00520-195-unknown	LAELVH...	195	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P00520-195-unknown	LAELVH...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198014
P00520-195-unknown	LAELVH...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198013
P00520-195-unknown	LAELVH...	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198012
P00520-319-unknown	TYGNLL...	319	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P00520-319-unknown	TYGNLL...	319	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198959
P00520-319-unknown	TYGNLL...	319	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198958
P00520-319-unknown	TYGNLL...	319	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198957

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PVASDF	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32296
...DIVRR	1123	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DIVRR	1123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61661
...DIVRR	1123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61662
...DIVRR	1123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61663

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	36	ASDF.\|.FEPQ	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.136)	16798735,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)